Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #43

serial: '43'
sid: '148488'
uuid: a07e4075-9365-4cfa-b90f-ef250f286557
uri: /nci/ccdisymposium/abstract
created: '1754682758'
completed: '1754683394'
changed: '1754683394'
in_draft: '0'
current_page: ''
remote_addr: 10.208.24.35
uid: '0'
langcode: en
webform_id: ccdi_symposium_abstract
entity_type: node
entity_id: '2139'
locked: '0'
sticky: '0'
notes: ''
metatag: meta
data:
  authors_:
    - add_author_degree: PhD
      add_author_first_name: Owen
      add_author_last_name: Chapman
      add_author_middle: S
      add_author_organization: 'Nagoya City University '
    - add_author_degree: MD
      add_author_first_name: Sunita
      add_author_last_name: Sridhar
      add_author_middle: ''
      add_author_organization: "Rady Children's Hospital San Diego"
    - add_author_degree: PhD
      add_author_first_name: Eugene
      add_author_last_name: Yui-Ching
      add_author_middle: ''
      add_author_organization: 'SBP Medical Discovery Institute'
    - add_author_degree: ''
      add_author_first_name: Rishaan
      add_author_last_name: Kenkre
      add_author_middle: ''
      add_author_organization: 'SBP Medical Discovery Institute'
    - add_author_degree: ''
      add_author_first_name: Jonathan
      add_author_last_name: Kirkland
      add_author_middle: ''
      add_author_organization: 'UC San Diego'
    - add_author_degree: ''
      add_author_first_name: Aditi
      add_author_last_name: Dutta
      add_author_middle: ''
      add_author_organization: 'UC San Diego'
    - add_author_degree: ''
      add_author_first_name: Shanqing
      add_author_last_name: Wang
      add_author_middle: ''
      add_author_organization: 'UC San Diego'
    - add_author_degree: ''
      add_author_first_name: Wenshu
      add_author_last_name: Zhang
      add_author_middle: ''
      add_author_organization: 'UC San Diego'
    - add_author_degree: PhD
      add_author_first_name: Miguel
      add_author_last_name: Brown
      add_author_middle: ''
      add_author_organization: "Children's Hospital of Philadelphia"
    - add_author_degree: PhD
      add_author_first_name: Jens
      add_author_last_name: Luebeck
      add_author_middle: ''
      add_author_organization: 'UC San Diego'
    - add_author_degree: ''
      add_author_first_name: Yan
      add_author_last_name: Lo
      add_author_middle: Yuen
      add_author_organization: 'SBP Medical Discovery Institute '
    - add_author_degree: PhD
      add_author_first_name: Elias
      add_author_last_name: Rodrigez-Fos
      add_author_middle: ''
      add_author_organization: 'Experimental and Clinical Research Center of the Max Delbrück Center and Charite Berlin'
    - add_author_degree: 'MD, PhD'
      add_author_first_name: Anton
      add_author_last_name: Henssen
      add_author_middle: G
      add_author_organization: 'Experimental and Clinical Research Center of the Max Delbrück Center and Charite Berlin'
    - add_author_degree: PhD
      add_author_first_name: Konstantin
      add_author_last_name: Okonechnikov
      add_author_middle: ''
      add_author_organization: 'Hopp Children’s Cancer Center Heidelberg (KiTZ)'
    - add_author_degree: 'MD, PhD'
      add_author_first_name: David
      add_author_last_name: Ghasemi
      add_author_middle: R
      add_author_organization: 'Hopp Children’s Cancer Center Heidelberg (KiTZ)'
    - add_author_degree: 'MD PhD'
      add_author_first_name: Kristian
      add_author_last_name: Pajtler
      add_author_middle: W
      add_author_organization: 'Hopp Children’s Cancer Center Heidelberg (KiTZ)'
    - add_author_degree: PhD
      add_author_first_name: Daisuke
      add_author_last_name: Kawauchi
      add_author_middle: ''
      add_author_organization: 'Nagoya City University'
    - add_author_degree: PhD
      add_author_first_name: Vineet
      add_author_last_name: Bafna
      add_author_middle: ''
      add_author_organization: 'UC San Diego'
    - add_author_degree: MD
      add_author_first_name: Megan
      add_author_last_name: Pau;
      add_author_middle: ''
      add_author_organization: "Rady Children's Hospital San Diego"
    - add_author_degree: PhD
      add_author_first_name: Kevin
      add_author_last_name: Yip
      add_author_middle: ''
      add_author_organization: 'SBP Medical Discovery Institute '
    - add_author_degree: PhD
      add_author_first_name: Jill
      add_author_last_name: Mesirov
      add_author_middle: ''
      add_author_organization: 'UC San Diego'
    - add_author_degree: PhD
      add_author_first_name: Lukas
      add_author_last_name: Chavez
      add_author_middle: ''
      add_author_organization: 'SBP Medical Discovery Institute '
  abstract: 'Circular extrachromosomal DNA (ecDNA) is a common form of oncogene amplification in aggressive cancers. The frequency and diversity of ecDNA has been catalogued in adult and some childhood cancers; however, its role in most pediatric cancers is not well-understood. To address this gap, we accessed large pediatric cancer genomics data repositories and identified ecDNA from whole genome sequencing data using cloud computing. This retrospective cohort comprises 3,631 solid tumor biopsies from 2,968 patients covering all major childhood solid tumor types. Aggressive tumor types had particularly high incidences of ecDNA. Pediatric patients whose tumors harbored extrachromosomal DNA had significantly poorer five-year overall survival than children whose tumors contained only chromosomal amplifications. We catalogue known and potentially novel oncogenes recurrently amplified on ecDNA and show that ecDNA often evolves during disease progression. These results highlight patient populations that could potentially benefit from future ecDNA-directed therapies. To facilitate discovery, we developed an interactive catalogue of ecDNA in childhood cancer at https://ccdi-ecdna.org/.'
  abstract_title_: 'Extrachromosomal DNA associates with poor survival across a broad spectrum of childhood solid tumors'
  email_address_: lchavez@sbpdiscovery.org
  institution_: 'SBP Medical Discovery Institite'
  presenting_author_: 'Lukas Chavez'