Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #43

Submission information
Submission Number: 43
Submission ID: 148488
Submission UUID: a07e4075-9365-4cfa-b90f-ef250f286557

Created: Fri, 08/08/2025 - 15:52
Completed: Fri, 08/08/2025 - 16:03
Changed: Fri, 08/08/2025 - 16:03

Remote IP address: 10.208.24.35
Submitted by: Anonymous
Language: English

Is draft: No
Abstract Submission for Poster Presentation
Extrachromosomal DNA associates with poor survival across a broad spectrum of childhood solid tumors
Circular extrachromosomal DNA (ecDNA) is a common form of oncogene amplification in aggressive cancers. The frequency and diversity of ecDNA has been catalogued in adult and some childhood cancers; however, its role in most pediatric cancers is not well-understood. To address this gap, we accessed large pediatric cancer genomics data repositories and identified ecDNA from whole genome sequencing data using cloud computing. This retrospective cohort comprises 3,631 solid tumor biopsies from 2,968 patients covering all major childhood solid tumor types. Aggressive tumor types had particularly high incidences of ecDNA. Pediatric patients whose tumors harbored extrachromosomal DNA had significantly poorer five-year overall survival than children whose tumors contained only chromosomal amplifications. We catalogue known and potentially novel oncogenes recurrently amplified on ecDNA and show that ecDNA often evolves during disease progression. These results highlight patient populations that could potentially benefit from future ecDNA-directed therapies. To facilitate discovery, we developed an interactive catalogue of ecDNA in childhood cancer at https://ccdi-ecdna.org/.
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  1. First Name: Owen
    Middle Initial: S
    Last Name: Chapman
    Degree(s): PhD
    Organization: Nagoya City University
  2. First Name: Sunita
    Last Name: Sridhar
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    Organization: Rady Children's Hospital San Diego
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    Organization: SBP Medical Discovery Institute
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    Organization: UC San Diego
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  7. First Name: Shanqing
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  8. First Name: Wenshu
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  9. First Name: Miguel
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    Last Name: Henssen
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    Organization: Experimental and Clinical Research Center of the Max Delbrück Center and Charite Berlin
  14. First Name: Konstantin
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    Organization: Hopp Children’s Cancer Center Heidelberg (KiTZ)
  15. First Name: David
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    Degree(s): MD, PhD
    Organization: Hopp Children’s Cancer Center Heidelberg (KiTZ)
  16. First Name: Kristian
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    Organization: Nagoya City University
  18. First Name: Vineet
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    Organization: UC San Diego
  19. First Name: Megan
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  21. First Name: Jill
    Last Name: Mesirov
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    Organization: UC San Diego
  22. First Name: Lukas
    Last Name: Chavez
    Degree(s): PhD
    Organization: SBP Medical Discovery Institute
Lukas Chavez
SBP Medical Discovery Institite