Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #43

Abstract Submission for Poster Presentation
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Abstract Title:: Extrachromosomal DNA associates with poor survival across a broad spectrum of childhood solid tumors
Abstract::
Circular extrachromosomal DNA (ecDNA) is a common form of oncogene amplification in aggressive cancers. The frequency and diversity of ecDNA has been catalogued in adult and some childhood cancers; however, its role in most pediatric cancers is not well-understood. To address this gap, we accessed large pediatric cancer genomics data repositories and identified ecDNA from whole genome sequencing data using cloud computing. This retrospective cohort comprises 3,631 solid tumor biopsies from 2,968 patients covering all major childhood solid tumor types. Aggressive tumor types had particularly high incidences of ecDNA. Pediatric patients whose tumors harbored extrachromosomal DNA had significantly poorer five-year overall survival than children whose tumors contained only chromosomal amplifications. We catalogue known and potentially novel oncogenes recurrently amplified on ecDNA and show that ecDNA often evolves during disease progression. These results highlight patient populations that could potentially benefit from future ecDNA-directed therapies. To facilitate discovery, we developed an interactive catalogue of ecDNA in childhood cancer at https://ccdi-ecdna.org/.

Abstract:: {Empty}
Authors::
1. First Name: Owen
   Middle Initial: S
   Last Name: Chapman
   Degree(s): PhD
   Organization: Nagoya City University 
2. First Name: Sunita
   Last Name: Sridhar
   Degree(s): MD
   Organization: Rady Children's Hospital San Diego
3. First Name: Eugene
   Last Name: Yui-Ching
   Degree(s): PhD
   Organization: SBP Medical Discovery Institute
4. First Name: Rishaan
   Last Name: Kenkre
   Organization: SBP Medical Discovery Institute
5. First Name: Jonathan
   Last Name: Kirkland
   Organization: UC San Diego
6. First Name: Aditi
   Last Name: Dutta
   Organization: UC San Diego
7. First Name: Shanqing
   Last Name: Wang
   Organization: UC San Diego
8. First Name: Wenshu
   Last Name: Zhang
   Organization: UC San Diego
9. First Name: Miguel
   Last Name: Brown
   Degree(s): PhD
   Organization: Children's Hospital of Philadelphia
10. First Name: Jens
    Last Name: Luebeck
    Degree(s): PhD
    Organization: UC San Diego
11. First Name: Yan
    Middle Initial: Yuen
    Last Name: Lo
    Organization: SBP Medical Discovery Institute 
12. First Name: Elias
    Last Name: Rodrigez-Fos
    Degree(s): PhD
    Organization: Experimental and Clinical Research Center of the Max Delbrück Center and Charite Berlin
13. First Name: Anton
    Middle Initial: G
    Last Name: Henssen
    Degree(s): MD, PhD
    Organization: Experimental and Clinical Research Center of the Max Delbrück Center and Charite Berlin
14. First Name: Konstantin
    Last Name: Okonechnikov
    Degree(s): PhD
    Organization: Hopp Children’s Cancer Center Heidelberg (KiTZ)
15. First Name: David
    Middle Initial: R
    Last Name: Ghasemi
    Degree(s): MD, PhD
    Organization: Hopp Children’s Cancer Center Heidelberg (KiTZ)
16. First Name: Kristian
    Middle Initial: W
    Last Name: Pajtler
    Degree(s): MD PhD
    Organization: Hopp Children’s Cancer Center Heidelberg (KiTZ)
17. First Name: Daisuke
    Last Name: Kawauchi
    Degree(s): PhD
    Organization: Nagoya City University
18. First Name: Vineet
    Last Name: Bafna
    Degree(s): PhD
    Organization: UC San Diego
19. First Name: Megan
    Last Name: Pau;
    Degree(s): MD
    Organization: Rady Children's Hospital San Diego
20. First Name: Kevin
    Last Name: Yip
    Degree(s): PhD
    Organization: SBP Medical Discovery Institute 
21. First Name: Jill
    Last Name: Mesirov
    Degree(s): PhD
    Organization: UC San Diego
22. First Name: Lukas
    Last Name: Chavez
    Degree(s): PhD
    Organization: SBP Medical Discovery Institute 

Presenting Author:: Lukas Chavez
Institution:: SBP Medical Discovery Institite
Email Address:: lchavez@sbpdiscovery.org