Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #45

serial: '45'
sid: '149218'
uuid: 4ee8fa76-2276-4b27-929f-454707b5521e
uri: /nci/ccdisymposium/abstract
created: '1755620149'
completed: '1755628200'
changed: '1755628200'
in_draft: '0'
current_page: ''
remote_addr: 10.208.28.152
uid: '0'
langcode: en
webform_id: ccdi_symposium_abstract
entity_type: node
entity_id: '2139'
locked: '0'
sticky: '0'
notes: ''
metatag: meta
data:
  authors_:
    - add_author_degree: Ph.D.
      add_author_first_name: Philip
      add_author_last_name: Lupo
      add_author_middle: J
      add_author_organization: 'Emory University'
    - add_author_degree: 'M.D., MPH'
      add_author_first_name: David
      add_author_last_name: Siegel
      add_author_middle: A
      add_author_organization: 'Centers for Disease Control and Prevention'
    - add_author_degree: BS
      add_author_first_name: Nicola
      add_author_last_name: Schussler
      add_author_middle: C
      add_author_organization: 'Information Management Services, Inc'
    - add_author_degree: Ph.D.
      add_author_first_name: Todd
      add_author_last_name: Alonzo
      add_author_middle: A
      add_author_organization: 'University of Southern California'
    - add_author_degree: 'ODS-C, BS'
      add_author_first_name: Suzanne
      add_author_last_name: Adams
      add_author_middle: ''
      add_author_organization: 'Information Management Services, Inc'
    - add_author_degree: MS
      add_author_first_name: David
      add_author_last_name: Angelaszek
      add_author_middle: ''
      add_author_organization: 'Information Management Services, Inc'
    - add_author_degree: MS
      add_author_first_name: Shanthala
      add_author_last_name: Basavappa
      add_author_middle: ''
      add_author_organization: 'Essex, an Emmes Company'
    - add_author_degree: MPH
      add_author_first_name: Tiffany
      add_author_last_name: Chambers
      add_author_middle: M
      add_author_organization: 'Baylor College of Medicine'
    - add_author_degree: BS
      add_author_first_name: Linda
      add_author_last_name: Colye
      add_author_middle: ''
      add_author_organization: 'Information Management Services, Inc'
    - add_author_degree: 'Dr.PH., MS'
      add_author_first_name: Eric
      add_author_last_name: Durbin
      add_author_middle: ''
      add_author_organization: 'University of Kentucky'
    - add_author_degree: MPH
      add_author_first_name: 'Johanna '
      add_author_last_name: Goderre
      add_author_middle: L
      add_author_organization: 'National Cancer Institute'
    - add_author_degree: MPH
      add_author_first_name: Tiffany
      add_author_last_name: Hayes
      add_author_middle: ''
      add_author_organization: 'Essex, an Emmes Company'
    - add_author_degree: BS
      add_author_first_name: Will
      add_author_last_name: Howe
      add_author_middle: ''
      add_author_organization: 'Information Management Services, Inc'
    - add_author_degree: Ph.D.
      add_author_first_name: Elizabeth
      add_author_last_name: Hsu
      add_author_middle: ''
      add_author_organization: 'National Cancer Institute'
    - add_author_degree: BS
      add_author_first_name: Richard
      add_author_last_name: Lee
      add_author_middle: ''
      add_author_organization: 'Information Management Services, Inc'
    - add_author_degree: 'Ph.D., MPH'
      add_author_first_name: Denise
      add_author_last_name: Lewis
      add_author_middle: 'R '
      add_author_organization: 'National Cancer Institute'
    - add_author_degree: Ph.D.
      add_author_first_name: Angela
      add_author_last_name: Mariotto
      add_author_middle: B
      add_author_organization: 'National Cancer Institute'
    - add_author_degree: 'Ph.D., MPH'
      add_author_first_name: Brad
      add_author_last_name: Pollock
      add_author_middle: H
      add_author_organization: 'University of California Davis'
    - add_author_degree: 'M.D., MPH'
      add_author_first_name: Anca
      add_author_last_name: Preda
      add_author_middle: ''
      add_author_organization: 'National Cancer Institute'
    - add_author_degree: M.D.
      add_author_first_name: Michael
      add_author_last_name: Roth
      add_author_middle: E
      add_author_organization: 'The University of Texas MD Anderson Cancer Center'
    - add_author_degree: BS
      add_author_first_name: Jennifer
      add_author_last_name: Stevens
      add_author_middle: ''
      add_author_organization: 'Information Management Services, Inc'
    - add_author_degree: MSc
      add_author_first_name: Tina
      add_author_last_name: Terranova
      add_author_middle: ''
      add_author_organization: ICF
    - add_author_degree: Ph.D.
      add_author_first_name: Sarah
      add_author_last_name: Vargas
      add_author_middle: L
      add_author_organization: "Children's Oncology Group"
    - add_author_degree: M.D.
      add_author_first_name: Douglas
      add_author_last_name: Hawkins
      add_author_middle: S
      add_author_organization: 'University of Washington'
    - add_author_degree: 'M.D., MPH'
      add_author_first_name: Lynne
      add_author_last_name: Penberthy
      add_author_middle: ''
      add_author_organization: 'National Cancer Institute'
  abstract: |
    Background: Improvements in outcomes among children and adolescents diagnosed with cancer are attributable to many factors, including clinical trials such as those administered through the Children’s Oncology Group (COG), as well as population-based resources like the National Childhood Cancer Registry (NCCR). The objective of this study was to link COG trial data with the NCCR to evaluate overall enrollment patterns.

    Methods: Data were received from the NCCR and COG, which were linked using an array of variables and then compared to evaluate enrollment patterns in COG studies from 2007-2018. Multivariable logistic regression was used to identify characteristics associated with not being enrolled in a COG study.

    Results: Among 134,696 NCCR cancer patients, 51,062 matched with COG study enrollees. There were several differences in demographic and clinical characteristics between those enrolled and not enrolled in COG studies. Enrollment was higher among children aged 0-4 years compared to adolescents aged 15-19 years (53.7% vs 20.1%). Differences by race and ethnicity were also observed; for example, those who identified as non-Hispanic White were more likely to be enrolled than those who identified as non-Hispanic Asian/Pacific Islander (38.8% vs 32.9%). In a multivariable logistic regression model, several characteristics were significantly associated with not being enrolled in a COG study, including age at diagnosis, year of diagnosis, race and ethnicity, and cancer type.

    Conclusion: Our results suggest that several groups are underrepresented in COG clinical trials. This information can help guide the prioritization of population groups for engagement in future studies.
  abstract_title_: 'Enrollment in Children’s Oncology Group’s Clinical Trials: Population-Based Linkage with the National Childhood Cancer Registry'
  email_address_: irn3@cdc.gov
  institution_: 'Centers for Disease Control and Prevention'
  presenting_author_: 'David Siegel'