Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #45

Abstract Submission for Poster Presentation
-------------------------------------------
Abstract Title:: Enrollment in Children’s Oncology Group’s Clinical Trials: Population-Based Linkage with the National Childhood Cancer Registry
Abstract::
Background: Improvements in outcomes among children and adolescents diagnosed with cancer are attributable to many factors, including clinical trials such as those administered through the Children’s Oncology Group (COG), as well as population-based resources like the National Childhood Cancer Registry (NCCR). The objective of this study was to link COG trial data with the NCCR to evaluate overall enrollment patterns.

Methods: Data were received from the NCCR and COG, which were linked using an array of variables and then compared to evaluate enrollment patterns in COG studies from 2007-2018. Multivariable logistic regression was used to identify characteristics associated with not being enrolled in a COG study.

Results: Among 134,696 NCCR cancer patients, 51,062 matched with COG study enrollees. There were several differences in demographic and clinical characteristics between those enrolled and not enrolled in COG studies. Enrollment was higher among children aged 0-4 years compared to adolescents aged 15-19 years (53.7% vs 20.1%). Differences by race and ethnicity were also observed; for example, those who identified as non-Hispanic White were more likely to be enrolled than those who identified as non-Hispanic Asian/Pacific Islander (38.8% vs 32.9%). In a multivariable logistic regression model, several characteristics were significantly associated with not being enrolled in a COG study, including age at diagnosis, year of diagnosis, race and ethnicity, and cancer type.

Conclusion: Our results suggest that several groups are underrepresented in COG clinical trials. This information can help guide the prioritization of population groups for engagement in future studies.


Abstract:: {Empty}
Authors::
1. First Name: Philip
   Middle Initial: J
   Last Name: Lupo
   Degree(s): Ph.D.
   Organization: Emory University
2. First Name: David
   Middle Initial: A
   Last Name: Siegel
   Degree(s): M.D., MPH
   Organization: Centers for Disease Control and Prevention
3. First Name: Nicola
   Middle Initial: C
   Last Name: Schussler
   Degree(s): BS
   Organization: Information Management Services, Inc
4. First Name: Todd
   Middle Initial: A
   Last Name: Alonzo
   Degree(s): Ph.D.
   Organization: University of Southern California
5. First Name: Suzanne
   Last Name: Adams
   Degree(s): ODS-C, BS
   Organization: Information Management Services, Inc
6. First Name: David
   Last Name: Angelaszek
   Degree(s): MS
   Organization: Information Management Services, Inc
7. First Name: Shanthala
   Last Name: Basavappa
   Degree(s): MS
   Organization: Essex, an Emmes Company
8. First Name: Tiffany
   Middle Initial: M
   Last Name: Chambers
   Degree(s): MPH
   Organization: Baylor College of Medicine
9. First Name: Linda
   Last Name: Colye
   Degree(s): BS
   Organization: Information Management Services, Inc
10. First Name: Eric
    Last Name: Durbin
    Degree(s): Dr.PH., MS
    Organization: University of Kentucky
11. First Name: Johanna 
    Middle Initial: L
    Last Name: Goderre
    Degree(s): MPH
    Organization: National Cancer Institute
12. First Name: Tiffany
    Last Name: Hayes
    Degree(s): MPH
    Organization: Essex, an Emmes Company
13. First Name: Will
    Last Name: Howe
    Degree(s): BS
    Organization: Information Management Services, Inc
14. First Name: Elizabeth
    Last Name: Hsu
    Degree(s): Ph.D.
    Organization: National Cancer Institute
15. First Name: Richard
    Last Name: Lee
    Degree(s): BS
    Organization: Information Management Services, Inc
16. First Name: Denise
    Middle Initial: R 
    Last Name: Lewis
    Degree(s): Ph.D., MPH
    Organization: National Cancer Institute
17. First Name: Angela
    Middle Initial: B
    Last Name: Mariotto
    Degree(s): Ph.D.
    Organization: National Cancer Institute
18. First Name: Brad
    Middle Initial: H
    Last Name: Pollock
    Degree(s): Ph.D., MPH
    Organization: University of California Davis
19. First Name: Anca
    Last Name: Preda
    Degree(s): M.D., MPH
    Organization: National Cancer Institute
20. First Name: Michael
    Middle Initial: E
    Last Name: Roth
    Degree(s): M.D.
    Organization: The University of Texas MD Anderson Cancer Center
21. First Name: Jennifer
    Last Name: Stevens
    Degree(s): BS
    Organization: Information Management Services, Inc
22. First Name: Tina
    Last Name: Terranova
    Degree(s): MSc
    Organization: ICF
23. First Name: Sarah
    Middle Initial: L
    Last Name: Vargas
    Degree(s): Ph.D.
    Organization: Children's Oncology Group
24. First Name: Douglas
    Middle Initial: S
    Last Name: Hawkins
    Degree(s): M.D.
    Organization: University of Washington
25. First Name: Lynne
    Last Name: Penberthy
    Degree(s): M.D., MPH
    Organization: National Cancer Institute

Presenting Author:: David Siegel
Institution:: Centers for Disease Control and Prevention
Email Address:: irn3@cdc.gov