Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #45

Submission information

Submission Number: 45

Submission ID: 149218

Submission UUID: 4ee8fa76-2276-4b27-929f-454707b5521e

Submission URI: /nci/ccdisymposium/abstract

Submission Update: /nci/ccdisymposium/abstract?token=TbqwSbflMzw3NJwocoIqm_jtD1q8qCzLRB7c0kCHIMY

Created: Tue, 08/19/2025 - 12:15

Completed: Tue, 08/19/2025 - 14:30

Changed: Tue, 08/19/2025 - 14:30

Remote IP address: 10.208.28.152

Submitted by: Anonymous

Language: English

Is draft: No

Webform: Childhood Cancer Data Initiative Annual Symposium (Abstracts Submission)

Submitted to: Childhood Cancer Data Initiative Annual Symposium (Abstract Registration)

Abstract Title:	Enrollment in Children’s Oncology Group’s Clinical Trials: Population-Based Linkage with the National Childhood Cancer Registry
Abstract:	Background: Improvements in outcomes among children and adolescents diagnosed with cancer are attributable to many factors, including clinical trials such as those administered through the Children’s Oncology Group (COG), as well as population-based resources like the National Childhood Cancer Registry (NCCR). The objective of this study was to link COG trial data with the NCCR to evaluate overall enrollment patterns. Methods: Data were received from the NCCR and COG, which were linked using an array of variables and then compared to evaluate enrollment patterns in COG studies from 2007-2018. Multivariable logistic regression was used to identify characteristics associated with not being enrolled in a COG study. Results: Among 134,696 NCCR cancer patients, 51,062 matched with COG study enrollees. There were several differences in demographic and clinical characteristics between those enrolled and not enrolled in COG studies. Enrollment was higher among children aged 0-4 years compared to adolescents aged 15-19 years (53.7% vs 20.1%). Differences by race and ethnicity were also observed; for example, those who identified as non-Hispanic White were more likely to be enrolled than those who identified as non-Hispanic Asian/Pacific Islander (38.8% vs 32.9%). In a multivariable logistic regression model, several characteristics were significantly associated with not being enrolled in a COG study, including age at diagnosis, year of diagnosis, race and ethnicity, and cancer type. Conclusion: Our results suggest that several groups are underrepresented in COG clinical trials. This information can help guide the prioritization of population groups for engagement in future studies.
Abstract:
Authors:	First Name: Philip Middle Initial: J Last Name: Lupo Degree(s): Ph.D. Organization: Emory University First Name: David Middle Initial: A Last Name: Siegel Degree(s): M.D., MPH Organization: Centers for Disease Control and Prevention First Name: Nicola Middle Initial: C Last Name: Schussler Degree(s): BS Organization: Information Management Services, Inc First Name: Todd Middle Initial: A Last Name: Alonzo Degree(s): Ph.D. Organization: University of Southern California First Name: Suzanne Last Name: Adams Degree(s): ODS-C, BS Organization: Information Management Services, Inc First Name: David Last Name: Angelaszek Degree(s): MS Organization: Information Management Services, Inc First Name: Shanthala Last Name: Basavappa Degree(s): MS Organization: Essex, an Emmes Company First Name: Tiffany Middle Initial: M Last Name: Chambers Degree(s): MPH Organization: Baylor College of Medicine First Name: Linda Last Name: Colye Degree(s): BS Organization: Information Management Services, Inc First Name: Eric Last Name: Durbin Degree(s): Dr.PH., MS Organization: University of Kentucky First Name: Johanna Middle Initial: L Last Name: Goderre Degree(s): MPH Organization: National Cancer Institute First Name: Tiffany Last Name: Hayes Degree(s): MPH Organization: Essex, an Emmes Company First Name: Will Last Name: Howe Degree(s): BS Organization: Information Management Services, Inc First Name: Elizabeth Last Name: Hsu Degree(s): Ph.D. Organization: National Cancer Institute First Name: Richard Last Name: Lee Degree(s): BS Organization: Information Management Services, Inc First Name: Denise Middle Initial: R Last Name: Lewis Degree(s): Ph.D., MPH Organization: National Cancer Institute First Name: Angela Middle Initial: B Last Name: Mariotto Degree(s): Ph.D. Organization: National Cancer Institute First Name: Brad Middle Initial: H Last Name: Pollock Degree(s): Ph.D., MPH Organization: University of California Davis First Name: Anca Last Name: Preda Degree(s): M.D., MPH Organization: National Cancer Institute First Name: Michael Middle Initial: E Last Name: Roth Degree(s): M.D. Organization: The University of Texas MD Anderson Cancer Center First Name: Jennifer Last Name: Stevens Degree(s): BS Organization: Information Management Services, Inc First Name: Tina Last Name: Terranova Degree(s): MSc Organization: ICF First Name: Sarah Middle Initial: L Last Name: Vargas Degree(s): Ph.D. Organization: Children's Oncology Group First Name: Douglas Middle Initial: S Last Name: Hawkins Degree(s): M.D. Organization: University of Washington First Name: Lynne Last Name: Penberthy Degree(s): M.D., MPH Organization: National Cancer Institute
Presenting Author:	David Siegel
Institution:	Centers for Disease Control and Prevention
Email Address:	irn3@cdc.gov