Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #63

serial: '63'
sid: '150536'
uuid: 29d5ea7f-20e3-44e9-b22b-49d3c5bf6334
uri: /nci/ccdisymposium/abstract
created: '1756824075'
completed: '1756824178'
changed: '1756824178'
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langcode: en
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data:
  authors_:
    - add_author_degree: ''
      add_author_first_name: SV
      add_author_last_name: Daulatabad
      add_author_middle: ''
      add_author_organization: ''
    - add_author_degree: ''
      add_author_first_name: A
      add_author_last_name: Jain
      add_author_middle: ''
      add_author_organization: ''
    - add_author_degree: ''
      add_author_first_name: D
      add_author_last_name: Nousome
      add_author_middle: ''
      add_author_organization: ''
    - add_author_degree: ''
      add_author_first_name: M
      add_author_last_name: Tandon
      add_author_middle: ''
      add_author_organization: ''
    - add_author_degree: ''
      add_author_first_name: D
      add_author_last_name: Varghese
      add_author_middle: ''
      add_author_organization: ''
    - add_author_degree: ''
      add_author_first_name: K
      add_author_last_name: Pendo
      add_author_middle: ''
      add_author_organization: ''
    - add_author_degree: ''
      add_author_first_name: MFW
      add_author_last_name: Malone
      add_author_middle: ''
      add_author_organization: ''
    - add_author_degree: ''
      add_author_first_name: J
      add_author_last_name: 'del Rivero'
      add_author_middle: ''
      add_author_organization: ''
    - add_author_degree: ''
      add_author_first_name: BC
      add_author_last_name: Widemann
      add_author_middle: ''
      add_author_organization: ''
    - add_author_degree: ''
      add_author_first_name: KM
      add_author_last_name: Reilly
      add_author_middle: ''
      add_author_organization: ''
  abstract: 'Endocrine cancers, including thyroid, adrenal, pituitary, and endocrine pancreatic cancers, are rare and understudied due to limited biospecimens and genomic data. We employed multi-omics approaches—RNA sequencing, whole-exome sequencing, and whole-genome sequencing—to elucidate molecular signatures and regulatory pathways in these cancers. We identified genes specific to various endocrine cancers, such as GNRHR, NPTX2, TAAR1, SLC6A5, and OPRM1. Co-expression network analysis revealed distinct neuronal pathways associated with cancer progression. Integrating protein-protein interaction and multi-omic aberrant gene interaction networks, we discovered pathways involving noradrenaline biosynthesis in pheochromocytomas, calcitonin regulation in medullary thyroid carcinoma, cholesterol biosynthesis in adrenocortical carcinoma, and the BRCA1-associated genome surveillance complex in papillary thyroid carcinoma. Our comprehensive multi-omic analysis offers novel insights into candidate therapeutic targets for these rare endocrine cancers.'
  abstract_file: '82815'
  abstract_title_: 'Integrative analysis of the rare endocrine cancers using multi-omics data'
  email_address_: vidhur.daulatabad@nih.gov
  institution_: 'National Institutes of Health/National Cancer Institute'
  presenting_author_: 'Vidhur Daulatabad'