Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #63

Abstract Submission for Poster Presentation
-------------------------------------------
Abstract Title:: Integrative analysis of the rare endocrine cancers using multi-omics data
Abstract::
Endocrine cancers, including thyroid, adrenal, pituitary, and endocrine pancreatic cancers, are rare and understudied due to limited biospecimens and genomic data. We employed multi-omics approaches—RNA sequencing, whole-exome sequencing, and whole-genome sequencing—to elucidate molecular signatures and regulatory pathways in these cancers. We identified genes specific to various endocrine cancers, such as GNRHR, NPTX2, TAAR1, SLC6A5, and OPRM1. Co-expression network analysis revealed distinct neuronal pathways associated with cancer progression. Integrating protein-protein interaction and multi-omic aberrant gene interaction networks, we discovered pathways involving noradrenaline biosynthesis in pheochromocytomas, calcitonin regulation in medullary thyroid carcinoma, cholesterol biosynthesis in adrenocortical carcinoma, and the BRCA1-associated genome surveillance complex in papillary thyroid carcinoma. Our comprehensive multi-omic analysis offers novel insights into candidate therapeutic targets for these rare endocrine cancers.

Abstract:: https://events.cancer.gov/system/files/webform/ccdi_symposium_abstract/150536/Vidhur_Daulatabad_Submission_details.docx
Authors::
1. First Name: SV
   Last Name: Daulatabad
2. First Name: A
   Last Name: Jain
3. First Name: D
   Last Name: Nousome
4. First Name: M
   Last Name: Tandon
5. First Name: D
   Last Name: Varghese
6. First Name: K
   Last Name: Pendo
7. First Name: MFW
   Last Name: Malone
8. First Name: J
   Last Name: del Rivero
9. First Name: BC
   Last Name: Widemann
10. First Name: KM
    Last Name: Reilly

Presenting Author:: Vidhur Daulatabad
Institution:: National Institutes of Health/National Cancer Institute
Email Address:: vidhur.daulatabad@nih.gov