Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #63

Submission information
Submission Number: 63
Submission ID: 150536
Submission UUID: 29d5ea7f-20e3-44e9-b22b-49d3c5bf6334

Created: Tue, 09/02/2025 - 10:41
Completed: Tue, 09/02/2025 - 10:42
Changed: Tue, 09/02/2025 - 10:42

Remote IP address: 10.208.28.30
Submitted by: chungs6
Language: English

Is draft: No
Abstract Submission for Poster Presentation
Integrative analysis of the rare endocrine cancers using multi-omics data
Endocrine cancers, including thyroid, adrenal, pituitary, and endocrine pancreatic cancers, are rare and understudied due to limited biospecimens and genomic data. We employed multi-omics approaches—RNA sequencing, whole-exome sequencing, and whole-genome sequencing—to elucidate molecular signatures and regulatory pathways in these cancers. We identified genes specific to various endocrine cancers, such as GNRHR, NPTX2, TAAR1, SLC6A5, and OPRM1. Co-expression network analysis revealed distinct neuronal pathways associated with cancer progression. Integrating protein-protein interaction and multi-omic aberrant gene interaction networks, we discovered pathways involving noradrenaline biosynthesis in pheochromocytomas, calcitonin regulation in medullary thyroid carcinoma, cholesterol biosynthesis in adrenocortical carcinoma, and the BRCA1-associated genome surveillance complex in papillary thyroid carcinoma. Our comprehensive multi-omic analysis offers novel insights into candidate therapeutic targets for these rare endocrine cancers.
  1. First Name: SV
    Last Name: Daulatabad
  2. First Name: A
    Last Name: Jain
  3. First Name: D
    Last Name: Nousome
  4. First Name: M
    Last Name: Tandon
  5. First Name: D
    Last Name: Varghese
  6. First Name: K
    Last Name: Pendo
  7. First Name: MFW
    Last Name: Malone
  8. First Name: J
    Last Name: del Rivero
  9. First Name: BC
    Last Name: Widemann
  10. First Name: KM
    Last Name: Reilly
Vidhur Daulatabad
National Institutes of Health/National Cancer Institute