Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #59

Abstract Submission for Poster Presentation
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Abstract Title:: Pediatric Extension of OncoTree: An Open-Source, Cancer Classification System
Abstract::
OncoTree is an open source, publicly accessible, community driven cancer classification system developed by Memorial Sloan Kettering Cancer Center and maintained by a cross-institutional committee of oncologists, pathologists, scientists, and engineers (OncoTree committee). Accessible through an intuitive web interface and API, OncoTree provides a structured hierarchical framework that standardizes cancer types, thereby supporting accurate diagnosis, therapeutic decision making, and data harmonization. Since its inception, OncoTree has grown to include over 900 tumor types, mapped to external terminologies such as NCI Thesaurus and UMLS, and is updated to align with standards like the World Health Organization (WHO) classification of tumors. All updates are publicly released with versioning, mapping tools, and detailed documentation to ensure transparency and reproducibility.

Initially focused on adult malignancies, OncoTree is now undergoing concentrated efforts to expand and refine its pediatric classification nodes. Pediatric cancers are biologically and clinically distinct from adult tumors, presenting unique challenges for classification. The pediatric extension of OncoTree aims to comprehensively represent childhood malignancies by incorporating WHO pediatric classifications, capturing rare and developmentally driven tumor entities, and restructuring ontology branches to better reflect pediatric tumor biology. This effort includes mapping diagnoses across ontology versions and external terminologies, identifying coverage gaps, and implementing systematic revisions under the governance of the OncoTree committee.

With clear documentation with release notes, source references, and support tools, this pediatric expansion will deliver a well-organized, transparent framework that improves the consistency of tumor classification, facilitates cross-study analyses, and strengthens the evidence base for clinical decision-making in childhood cancer care.

Abstract:: {Empty}
Authors::
1. First Name: Ritika
   Last Name: Kundra
   Degree(s): M.S.
   Organization: MSK
2. First Name: Rima
   Last Name: AlHamad
   Degree(s): M.S.
   Organization: MSK
3. First Name: Robert
   Last Name: Sheridan
   Degree(s): M.S.
   Organization: MSK
4. First Name: Manda
   Last Name: Wilson
   Degree(s): M.S.
   Organization: MSK
5. First Name: Avery
   Last Name: Wang
   Degree(s): M.S.
   Organization: MSK
6. First Name: Benjamin
   Last Name: Preiser
   Degree(s): B.S.
   Organization: MSK
7. First Name: Benjamin
   Last Name: Gross
   Degree(s): M.S.
   Organization: MSK
8. First Name: Kelly
   Last Name: Cavender
   Degree(s): B.S.
   Organization: MSK
9. First Name: Sarah
   Middle Initial: P
   Last Name: Suehnholz
   Degree(s): Ph.D.
   Organization: MSK
10. First Name: Ramyasree
    Last Name: Madupuri
    Degree(s): M.S.
    Organization: MSK
11. First Name: Baby
    Middle Initial: A
    Last Name: Satravada
    Degree(s): M.S.
    Organization: MSK
12. First Name: Neerav
    Middle Initial: N
    Last Name: Shukla
    Degree(s): M.D.
    Organization: MSK
13. First Name: Stephanie
    Last Name: Suser
    Degree(s): B.A.
    Organization: MSK
14. First Name: Mark
    Last Name: Ewalt
    Degree(s): M.D.
    Organization: MSK
15. First Name: Tejus
    Last Name: Bale
    Degree(s): M.D., Ph.D.
    Organization: MSK
16. First Name: Maria
    Middle Initial: E
    Last Name: Arcila
    Degree(s): M.D.
    Organization: MSK
17. First Name: Aijaz
    Last Name: Syed
    Degree(s): M.S.
    Organization: MSK
18. First Name: Mihir
    Last Name: Kavatkar
    Degree(s): M.S.
    Organization: MSK
19. First Name: Tali
    Last Name: Mazor
    Degree(s): Ph.D.
    Organization: DFCI
20. First Name: Ethan
    Last Name: Cerami
    Degree(s): Ph.D.
    Organization: DFCI
21. First Name: Justin
    Last Name: Jee
    Degree(s): M.D., Ph.D.
    Organization: MSK
22. First Name: Christopher
    Last Name: Fong
    Degree(s): Ph.D.
    Organization: MSK
23. First Name: Michele
    Last Name: Waters
    Degree(s): Ph.D.
    Organization: MSK
24. First Name: Michael
    Middle Initial: F
    Last Name: Berger
    Degree(s): Ph.D.
    Organization: MSK
25. First Name: Debyani
    Last Name: Chakravarty
    Degree(s): Ph.D.
    Organization: MSK
26. First Name: Ingo
    Middle Initial: K
    Last Name: Mellinghoff
    Degree(s): M.D., F.A.C.P.
    Organization: MSK
27. First Name: David
    Middle Initial: B
    Last Name: Solit
    Degree(s): M.D.
    Organization: MSK
28. First Name: JianJiong
    Last Name: Gao
    Degree(s): Ph.D.
    Organization: MSK
29. First Name: Nikolaus
    Last Name: Schultz
    Degree(s): Ph.D.
    Organization: MSK

Presenting Author:: Ritika Kundra
Institution:: Memorial Sloan Kettering
Email Address:: kundrar@mskcc.org