Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #59

Submission information

Submission Number: 59

Submission ID: 150490

Submission UUID: a536d34d-7419-40b2-88d3-29ab3407dfe6

Submission URI: /nci/ccdisymposium/abstract

Submission Update: /nci/ccdisymposium/abstract?token=Uwvjh5JqrOn2m_MCmD2kULy9GGUkcw6iRG5d0Bq9TQs

Created: Mon, 09/01/2025 - 20:30

Completed: Mon, 09/01/2025 - 21:17

Changed: Mon, 09/01/2025 - 21:17

Remote IP address: 10.208.28.30

Submitted by: Anonymous

Language: English

Is draft: No

Webform: Childhood Cancer Data Initiative Annual Symposium (Abstracts Submission)

Submitted to: Childhood Cancer Data Initiative Annual Symposium (Abstract Registration)

Abstract Title:	Pediatric Extension of OncoTree: An Open-Source, Cancer Classification System
Abstract:	OncoTree is an open source, publicly accessible, community driven cancer classification system developed by Memorial Sloan Kettering Cancer Center and maintained by a cross-institutional committee of oncologists, pathologists, scientists, and engineers (OncoTree committee). Accessible through an intuitive web interface and API, OncoTree provides a structured hierarchical framework that standardizes cancer types, thereby supporting accurate diagnosis, therapeutic decision making, and data harmonization. Since its inception, OncoTree has grown to include over 900 tumor types, mapped to external terminologies such as NCI Thesaurus and UMLS, and is updated to align with standards like the World Health Organization (WHO) classification of tumors. All updates are publicly released with versioning, mapping tools, and detailed documentation to ensure transparency and reproducibility. Initially focused on adult malignancies, OncoTree is now undergoing concentrated efforts to expand and refine its pediatric classification nodes. Pediatric cancers are biologically and clinically distinct from adult tumors, presenting unique challenges for classification. The pediatric extension of OncoTree aims to comprehensively represent childhood malignancies by incorporating WHO pediatric classifications, capturing rare and developmentally driven tumor entities, and restructuring ontology branches to better reflect pediatric tumor biology. This effort includes mapping diagnoses across ontology versions and external terminologies, identifying coverage gaps, and implementing systematic revisions under the governance of the OncoTree committee. With clear documentation with release notes, source references, and support tools, this pediatric expansion will deliver a well-organized, transparent framework that improves the consistency of tumor classification, facilitates cross-study analyses, and strengthens the evidence base for clinical decision-making in childhood cancer care.
Abstract:
Authors:	First Name: Ritika Last Name: Kundra Degree(s): M.S. Organization: MSK First Name: Rima Last Name: AlHamad Degree(s): M.S. Organization: MSK First Name: Robert Last Name: Sheridan Degree(s): M.S. Organization: MSK First Name: Manda Last Name: Wilson Degree(s): M.S. Organization: MSK First Name: Avery Last Name: Wang Degree(s): M.S. Organization: MSK First Name: Benjamin Last Name: Preiser Degree(s): B.S. Organization: MSK First Name: Benjamin Last Name: Gross Degree(s): M.S. Organization: MSK First Name: Kelly Last Name: Cavender Degree(s): B.S. Organization: MSK First Name: Sarah Middle Initial: P Last Name: Suehnholz Degree(s): Ph.D. Organization: MSK First Name: Ramyasree Last Name: Madupuri Degree(s): M.S. Organization: MSK First Name: Baby Middle Initial: A Last Name: Satravada Degree(s): M.S. Organization: MSK First Name: Neerav Middle Initial: N Last Name: Shukla Degree(s): M.D. Organization: MSK First Name: Stephanie Last Name: Suser Degree(s): B.A. Organization: MSK First Name: Mark Last Name: Ewalt Degree(s): M.D. Organization: MSK First Name: Tejus Last Name: Bale Degree(s): M.D., Ph.D. Organization: MSK First Name: Maria Middle Initial: E Last Name: Arcila Degree(s): M.D. Organization: MSK First Name: Aijaz Last Name: Syed Degree(s): M.S. Organization: MSK First Name: Mihir Last Name: Kavatkar Degree(s): M.S. Organization: MSK First Name: Tali Last Name: Mazor Degree(s): Ph.D. Organization: DFCI First Name: Ethan Last Name: Cerami Degree(s): Ph.D. Organization: DFCI First Name: Justin Last Name: Jee Degree(s): M.D., Ph.D. Organization: MSK First Name: Christopher Last Name: Fong Degree(s): Ph.D. Organization: MSK First Name: Michele Last Name: Waters Degree(s): Ph.D. Organization: MSK First Name: Michael Middle Initial: F Last Name: Berger Degree(s): Ph.D. Organization: MSK First Name: Debyani Last Name: Chakravarty Degree(s): Ph.D. Organization: MSK First Name: Ingo Middle Initial: K Last Name: Mellinghoff Degree(s): M.D., F.A.C.P. Organization: MSK First Name: David Middle Initial: B Last Name: Solit Degree(s): M.D. Organization: MSK First Name: JianJiong Last Name: Gao Degree(s): Ph.D. Organization: MSK First Name: Nikolaus Last Name: Schultz Degree(s): Ph.D. Organization: MSK
Presenting Author:	Ritika Kundra
Institution:	Memorial Sloan Kettering
Email Address:	kundrar@mskcc.org