Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #14

serial: '14'
sid: '127589'
uuid: 087bc485-6347-4ec5-81ac-7e873aa76c7a
uri: /egrp/cohortconsortium/abstracts
created: '1726268585'
completed: '1726268796'
changed: '1726519206'
in_draft: '0'
current_page: ''
remote_addr: 10.208.24.118
uid: '0'
langcode: en
webform_id: cohort_2024_abstracts_submission
entity_type: node
entity_id: '1467'
locked: '0'
sticky: '0'
notes: ''
data:
  additional_authors:
    - add_author_degree: Ph.D.
      add_author_first_name: Leticia
      add_author_last_name: Palma
      add_author_middle: ''
      add_author_organization: 'National Institute of Public Health'
    - add_author_degree: Ph.D.
      add_author_first_name: Dalia
      add_author_last_name: Stern
      add_author_middle: ''
      add_author_organization: 'CONAHCYT-National Institute of Public Health'
    - add_author_degree: 'M.D., MPH'
      add_author_first_name: 'Marion '
      add_author_last_name: Brochier
      add_author_middle: ''
      add_author_organization: 'National Institute of Public Health'
    - add_author_degree: MPH
      add_author_first_name: Adrian
      add_author_last_name: Cortes-Valencia
      add_author_middle: ''
      add_author_organization: 'National Institute of Public Health'
    - add_author_degree: MPH
      add_author_first_name: Adriana
      add_author_last_name: Monge
      add_author_middle: ''
      add_author_organization: 'National Institute of Public Health'
    - add_author_degree: Ph.D.
      add_author_first_name: Laura
      add_author_last_name: Quezada
      add_author_middle: ''
      add_author_organization: 'National Institute of Public Health'
    - add_author_degree: 'M.D., DPH'
      add_author_first_name: Martin
      add_author_last_name: Lajous
      add_author_middle: ''
      add_author_organization: 'National Institute of Public Health, Harvard'
  degree_s_: Ph.D.
  email: liliana.gomez@insp.mx
  first_name: Liliana
  last_name: Gomez-Flores-Ramos
  organization: 'CONAHCYT-National Institute of Public Health, Mexico'
  poster_title: 'Added Sugar Intake and Breast Cancer Risk: Findings from the Mexican Teachers'' Cohort'
  short_biography_: |
    Background: Mexico has a high consumption of added sugars (AS), and previous have suggested a potential link between carbohydrate intake and breast cancer (BC) incidence in Mexico. However, this association has not been confirmed in a prospective study. We aimed to estimate the effect of AS intake on BC in the Mexican Teachers’ Cohort. 

    Methods: We assessed diet in 89,879 BC-free women using a validated FFQ in the 2006-2008 baseline assessment. We estimated AS using a standardized procedure. BC diagnoses from baseline to December 2019 were validated using electronic health records and cancer and mortality registries. The data was analyzed using adjusted multivariable Cox regression models and AS was modeled with restricted cubic splines. Women were categorized based on their daily AS intake (< 31 g/d, 31-60 g/d, 61-90 g/d, and over 91 g/day) as per the EAT-Lancet recommendation. We calculated the estimates for overall, premenopausal, and postmenopausal BC. 

    Results: The median AS intake was 52g/day (IQR 36-77), and 1,313 BC cases were confirmed over a median follow-up of 10.9 years. Overall, a nonlinear dose-response relationship with limited HR elevation was observed. For premenopausal BC, HR peaked at 1.4 and remained relatively stable after 50g/day. Compared to women in the lowest category of AS (≤31 g/day), women in the highest category (≥ 91g/day) had a higher incidence of BC (HR=1.34, 95%CI 0.93, 1.92). No significant increase was observed for postmenopausal women. 

    Conclusion: Our findings suggest that AS may play a role in the incidence of premenopausal BC in Mexican women.
  title: Professor