Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #14

Lightning Talks Abstract
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Presenter's First Name: : Liliana









Presenter's Last Name:: Gomez-Flores-Ramos









Title (eg: professor, assistant professor, chair, etc):: Professor









Degree(s): Ph.D.









Contact Email:: liliana.gomez@insp.mx









Organization:: CONAHCYT-National Institute of Public Health, Mexico









Project Title:: Added Sugar Intake and Breast Cancer Risk: Findings from the Mexican Teachers' Cohort









Additional Authors:
1. First Name: Leticia
   Last Name: Palma
   Degree(s): Ph.D.
   Organization: National Institute of Public Health
2. First Name: Dalia
   Last Name: Stern
   Degree(s): Ph.D.
   Organization: CONAHCYT-National Institute of Public Health
3. First Name: Marion 
   Last Name: Brochier
   Degree(s): M.D., MPH
   Organization: National Institute of Public Health
4. First Name: Adrian
   Last Name: Cortes-Valencia
   Degree(s): MPH
   Organization: National Institute of Public Health
5. First Name: Adriana
   Last Name: Monge
   Degree(s): MPH
   Organization: National Institute of Public Health
6. First Name: Laura
   Last Name: Quezada
   Degree(s): Ph.D.
   Organization: National Institute of Public Health
7. First Name: Martin
   Last Name: Lajous
   Degree(s): M.D., DPH
   Organization: National Institute of Public Health, Harvard










Abstract::
Background: Mexico has a high consumption of added sugars (AS), and previous have suggested a potential link between carbohydrate intake and breast cancer (BC) incidence in Mexico. However, this association has not been confirmed in a prospective study. We aimed to estimate the effect of AS intake on BC in the Mexican Teachers’ Cohort. 

Methods: We assessed diet in 89,879 BC-free women using a validated FFQ in the 2006-2008 baseline assessment. We estimated AS using a standardized procedure. BC diagnoses from baseline to December 2019 were validated using electronic health records and cancer and mortality registries. The data was analyzed using adjusted multivariable Cox regression models and AS was modeled with restricted cubic splines. Women were categorized based on their daily AS intake (< 31 g/d, 31-60 g/d, 61-90 g/d, and over 91 g/day) as per the EAT-Lancet recommendation. We calculated the estimates for overall, premenopausal, and postmenopausal BC. 

Results: The median AS intake was 52g/day (IQR 36-77), and 1,313 BC cases were confirmed over a median follow-up of 10.9 years. Overall, a nonlinear dose-response relationship with limited HR elevation was observed. For premenopausal BC, HR peaked at 1.4 and remained relatively stable after 50g/day. Compared to women in the lowest category of AS (≤31 g/day), women in the highest category (≥ 91g/day) had a higher incidence of BC (HR=1.34, 95%CI 0.93, 1.92). No significant increase was observed for postmenopausal women. 

Conclusion: Our findings suggest that AS may play a role in the incidence of premenopausal BC in Mexican women.