Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #11

serial: '11'
sid: '127538'
uuid: 21f64508-9f4f-427a-abd1-63f2fdd74b7e
uri: /egrp/cohortconsortium/abstracts
created: '1726242027'
completed: '1726242466'
changed: '1726519367'
in_draft: '0'
current_page: ''
remote_addr: 10.208.24.118
uid: '0'
langcode: en
webform_id: cohort_2024_abstracts_submission
entity_type: node
entity_id: '1467'
locked: '0'
sticky: '0'
notes: ''
data:
  additional_authors:
    - add_author_degree: PhD
      add_author_first_name: Valeria
      add_author_last_name: Elahy
      add_author_middle: ''
      add_author_organization: 'American Cancer Society'
    - add_author_degree: MSPH
      add_author_first_name: 'Christina '
      add_author_last_name: Newton
      add_author_middle: ''
      add_author_organization: 'American Cancer Society'
    - add_author_degree: PhD
      add_author_first_name: Alpa
      add_author_last_name: Patel
      add_author_middle: ''
      add_author_organization: 'American Cancer Society'
    - add_author_degree: 'ScD, RD'
      add_author_first_name: Marji
      add_author_last_name: McCullough
      add_author_middle: ''
      add_author_organization: 'American Cancer Society'
    - add_author_degree: PhD
      add_author_first_name: Lauren
      add_author_last_name: Teras
      add_author_middle: ''
      add_author_organization: 'American Cancer Society'
    - add_author_degree: PhD
      add_author_first_name: Clara
      add_author_last_name: Bodelon
      add_author_middle: ''
      add_author_organization: 'American Cancer Society'
    - add_author_degree: 'PhD, MPH, RD'
      add_author_first_name: Caroline
      add_author_last_name: Um
      add_author_middle: ''
      add_author_organization: 'American Cancer Society'
    - add_author_degree: 'PhD, MPH'
      add_author_first_name: Erika
      add_author_last_name: Rees-Punia
      add_author_middle: ''
      add_author_organization: 'American Cancer Society'
    - add_author_degree: DO
      add_author_first_name: Laura
      add_author_last_name: Mararoff
      add_author_middle: ''
      add_author_organization: 'American Cancer Society'
    - add_author_degree: 'PhD, MS'
      add_author_first_name: Ying
      add_author_last_name: Wang
      add_author_middle: ''
      add_author_organization: 'American Cancer Society'
  degree_s_: PhD
  email: valeria.elahy@cancer.org
  first_name: Valeria
  last_name: Elahy
  organization: 'American Cancer Society'
  poster_title: 'Post-diagnosis Adherence to American Cancer Society Guidelines and Mortality Among Prostate Cancer Patients in the Cancer Prevention Study-II Nutrition Cohort'
  short_biography_: |-
    Purpose: The American Cancer Society (ACS) Guidelines on Nutrition and Physical Activity for Cancer Survivors recommend avoiding obesity, engaging in regular physical activity, following a healthy diet, and limiting alcohol intake. This study aimed to assess the association between adherence to these guidelines and all-cause mortality, cardiovascular disease mortality (CVDM), and prostate cancer-specific mortality (PCSM) among prostate cancer patients and to explore whether the association varies by tumor aggressiveness.

    Methods: Data from 4,232 prostate cancer patients in the Cancer Prevention Study-II Nutrition Cohort were analyzed. Adherence to ACS guidelines was scored (0-8), with higher scores indicating greater adherence. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality were calculated using Cox proportional hazards regression models. 

    Results: Higher ACS guideline score was associated with lower risk of all-cause mortality (HR for score 6-8 vs. 0-3: 0.77; 95% CI, 0.69 to 0.85), CVDM (HR: 0.75; 95% CI, 0.63 to 0.91), and PCSM (HR: 0.79; 95% CI, 0.60 to 1.03). Among patients with non-aggressive tumors, higher adherence was associated with significantly lower all-cause mortality (HR: 0.78; 95% CI, 0.70 to 0.87) and CVDM (HR: 0.79; 95% CI, 0.65 to 0.98) but not PCSM. A higher score was associated with lower all-cause mortality (HR: 0.75; 95% CI, 0.58 to 0.95) but not CVDM or PCSM among men with aggressive tumors. 

    Conclusion: Adherence to ACS guidelines was associated with lower all-cause mortality and CVDM in prostate cancer patients, particularly those with non-aggressive tumors. These findings emphasize the potential benefit of post-diagnosis lifestyle modifications.
  title: 'Postdoctoral Fellow'