Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #11

Submission information
Submission Number: 11
Submission ID: 127538
Submission UUID: 21f64508-9f4f-427a-abd1-63f2fdd74b7e

Created: Fri, 09/13/2024 - 11:40
Completed: Fri, 09/13/2024 - 11:47
Changed: Mon, 09/16/2024 - 16:42

Remote IP address: 10.208.24.118
Submitted by: Anonymous
Language: English

Is draft: No
Presenter's First Name: Valeria
Presenter's Last Name: Elahy
Title (eg: professor, assistant professor, chair, etc): Postdoctoral Fellow
Degree(s) PhD
Contact Email: valeria.elahy@cancer.org
Organization: American Cancer Society
Project Title: Post-diagnosis Adherence to American Cancer Society Guidelines and Mortality Among Prostate Cancer Patients in the Cancer Prevention Study-II Nutrition Cohort
Additional Authors
  1. First Name: Valeria
    Last Name: Elahy
    Degree(s): PhD
    Organization: American Cancer Society
  2. First Name: Christina
    Last Name: Newton
    Degree(s): MSPH
    Organization: American Cancer Society
  3. First Name: Alpa
    Last Name: Patel
    Degree(s): PhD
    Organization: American Cancer Society
  4. First Name: Marji
    Last Name: McCullough
    Degree(s): ScD, RD
    Organization: American Cancer Society
  5. First Name: Lauren
    Last Name: Teras
    Degree(s): PhD
    Organization: American Cancer Society
  6. First Name: Clara
    Last Name: Bodelon
    Degree(s): PhD
    Organization: American Cancer Society
  7. First Name: Caroline
    Last Name: Um
    Degree(s): PhD, MPH, RD
    Organization: American Cancer Society
  8. First Name: Erika
    Last Name: Rees-Punia
    Degree(s): PhD, MPH
    Organization: American Cancer Society
  9. First Name: Laura
    Last Name: Mararoff
    Degree(s): DO
    Organization: American Cancer Society
  10. First Name: Ying
    Last Name: Wang
    Degree(s): PhD, MS
    Organization: American Cancer Society
Abstract: Purpose: The American Cancer Society (ACS) Guidelines on Nutrition and Physical Activity for Cancer Survivors recommend avoiding obesity, engaging in regular physical activity, following a healthy diet, and limiting alcohol intake. This study aimed to assess the association between adherence to these guidelines and all-cause mortality, cardiovascular disease mortality (CVDM), and prostate cancer-specific mortality (PCSM) among prostate cancer patients and to explore whether the association varies by tumor aggressiveness.

Methods: Data from 4,232 prostate cancer patients in the Cancer Prevention Study-II Nutrition Cohort were analyzed. Adherence to ACS guidelines was scored (0-8), with higher scores indicating greater adherence. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality were calculated using Cox proportional hazards regression models.

Results: Higher ACS guideline score was associated with lower risk of all-cause mortality (HR for score 6-8 vs. 0-3: 0.77; 95% CI, 0.69 to 0.85), CVDM (HR: 0.75; 95% CI, 0.63 to 0.91), and PCSM (HR: 0.79; 95% CI, 0.60 to 1.03). Among patients with non-aggressive tumors, higher adherence was associated with significantly lower all-cause mortality (HR: 0.78; 95% CI, 0.70 to 0.87) and CVDM (HR: 0.79; 95% CI, 0.65 to 0.98) but not PCSM. A higher score was associated with lower all-cause mortality (HR: 0.75; 95% CI, 0.58 to 0.95) but not CVDM or PCSM among men with aggressive tumors.

Conclusion: Adherence to ACS guidelines was associated with lower all-cause mortality and CVDM in prostate cancer patients, particularly those with non-aggressive tumors. These findings emphasize the potential benefit of post-diagnosis lifestyle modifications.