Annual PI Meeting for the Innovative Molecular Analysis Technologies (IMAT) Program (Active Projects)

Active Projects

 

R33CA240201 VAN DAM, ROBERT MICHAEL Optimization and validation of integrated microscale technologies for low-cost, automated production of PET molecular imaging tracers for cancer research
R21CA217662 IM, HYUNGSOON  Nano-plasmonic technology for high-throughput single exosome analyses
R21CA246358 SEELIG, GEORG  (contact); WU, DAVID  High-resolution spatial transcriptomics through light patterning
R33CA246363 LEVINSON, NICHOLAS MARK Time-resolved FRET-based allostery sensors for any protein kinase drug target
R21CA223727 HUANG, XIAOHUA  Technology for measuring telomere length of individual chromosomes of single cancer cells
R21CA247638 LIANG, FU-SEN  Spatiotemporal Epitranscriptome Editing Technology
R33CA247739 BHATNAGAR, PARIJAT  T-cell Biofactories for targeting extracellular matrix
R33CA225458 KETTENBACH, ARMINJA NADINE (contact); GERBER, SCOTT A Activity based profiling of Phosphoprotein phosphatases in cancer using mass spectrometry-based proteomics
R21CA240185 LI, WEI  Fractionation and Profiling of Heterogeneous Circulating Tumor Cells Using a Hyperuniform- Structured Microchip
R21CA251952 FOLCH, ALBERT  (contact); PIERCE, ROBERT H High-content functional cancer drug testing on micro-cuboidal tumor dissections
R33CA246448 HALL, ADAM ROGER Detecting diverse nucleic acid biomarkers of cancer with solid-state nanopores
R33CA225539 JIANG, NING JENNY An integrated therapeutic T cell receptor screening platform for adoptive cell therapy in cancer
R21CA256084 DI CARLO, DINO  Lab on a particle technology for functional screening of therapeutic cells
R21CA256128 DEININGER, MICHAEL W A Bioluminescent Assay for Direct Measurement of Sirtuin Activity in Cancer Cells
R21CA240199 O'NEILL, RACHEL  Development and Utilization of Splice-specific Antibodies
R33CA235597 SOPER, STEVEN ALLAN (contact); AUGUST, KEITH  Increased Sensitivity of Minimal Residual Disease Monitoring using Peripheral Blood in Pediatric Patients with Acute Lymphoblastic Leukemia
R21CA258008 SCARCELLI, GIULIANO  (contact); KONSTANTOPOULOS, KONSTANTINOS ; MARTIN, STUART S Stimulated Brillouin Flow Cytometry for biomechanical assessment of metastatic potential
R21CA229024 HUR, SOOJUNG CLAIRE Development of a microfluidic primary cell editing platform (pCEP) for personal gene therapy
R21CA247647 WILSON, GERALD M Suppressing oncogenic RNA regulons using engineered zinc finger ribonucleases
R21CA256082 BAR-PELED, LIRON  Chemical Proteomic Identification of Druggable Oncogenic Transcription Factors
R21CA257980 BELCHER, ANGELA M (contact); MALEY, CARLO  A cell-cycle induced genetic recorder for simultaneous recovery of cell divisions and lineage
R33CA247700 JI, HANLEE P Multimodal iterative sequencing of cancer genomes and single tumor cells
R21CA236653 ISSADORE, DAVID AARON High Throughput Digital Droplet ELISA for Ultrasensitive Multiplexed Diagnostics
R33CA235294 WANG, SHAOPENG  A Virion-Display Oscillator Array and Detection Platform for Quantification of Transmembrane Protein Binding Kinetics
R21CA250597 ZHANG, FANGLIANG  Targeted degradation of proteins by affinity peptide conjugated ubiquitin (APCU)
R21CA251015 STILL, AMANDA NICOLE HAYMOND New Hybrid Molecular Modalities Comprised of DNA-Origami and Interfering Peptides as Inhibitors of Protein-Protein Interactions
R21CA255894 XIAO, HAN  (contact); YUSTEIN, JASON  Development of Bone-Targeting Antibodies for Ewing Sarcoma Using Genetic Code Expansion
R21CA256081 SWAGER, TIMOTHY M Innovative Droplet Lenses for NextGen Light Sensors of Biomarkers of Inflammation
R33CA255893 SEELIG, GEORG  Joint receptor and protein expression immunophenotyping through split-pool barcoding
R33CA257878 HANSEN, ANDERS SEJR Super-resolution microscopy for dynamic analysis of focal enhancer amplifications in cancer
R21CA236665 SANTORE, MARIA M Paper-based Breastmilk Collection System for Facile, In-Home Use
R21CA258019 CHEN, KAI  (contact); MCKENNA, CHARLES E Novel Bisphosphonate PET Probes for Myeloma Bone Disease
R33CA247744 GARTNER, ZEV JORDAN Universal Sample Multiplexing for Single Cell Analysis
R33CA251006 HAUN, JERED BRACKSTON Microfluidic tumor tissue processing platform for single cell diagnostics
R33CA258016 LIU, XUEFENG  Validating Urine Derived Cancer Cells (UDCC) -- Non-Invasive and Living Liquid Biopsies -- in Bladder Cancer Clinics
R33CA252158 ZENG, YONG  (contact); XU, LIANG  Integrative Functional Profiling of Tumor-Derived Extracellular Vesicles
R21CA251027 SCHULMAN, REBECCA  Secretion responsive Hydrogels for Identification of Functional single T cells (SHIFT)
R21CA251043 HOSHIKA, SHUICHI  High Quality Proteins with Multiple Post Translational Modifications
R21CA255979 DIDENKO, VLADIMIR V In situ assay imaging nuclear RNA exosome activity for cancer studies
R21CA261734 AKSAN, ALPTEKIN  Novel cryopreservation method for stabilization of manufactured therapeutic cells
R21CA261737 HAINER, SARAH JANE (contact); SHI, YI  Using nanobodies to increase the sensitivity and resolution of chromatin profiling through uliCUT&RUN
R21CA263147 BHARGAVA, ROHIT  Spectroscopy Assisted Laser Microdissection
R21CA272345 KNOWLES, DAVID ARTHUR A CRISPR/Cas13 approach for identifying individual transcript isoform function in cancer
R33CA256086 JIANG, NING JENNY (contact); BROCK, AMY  A streamlined, high-throughput platform for validation of cancer antigen presentation and isolation of cancer antigen reactive T cells
R33CA256112 WEI, WEI  Liquid biopsy-based toolkits for neoantigen and cognate TCR discovery for cancer immunotherapy
R33CA261726 CHENG, JI-XIN  Mapping Cancer Metabolism by Mid-infrared Photothermal Microscopy
R21CA250999 BORGES, CHAD R Aliquot-level visual indicators of biospecimen exposure to thawed conditions
R21CA257864 BOYLE, ALAN P High-throughput inverted reporter assay for characterization of silencers and enhancer blockers
R21CA267222 LEE, HAKHO  3D Fourier Imaging System for High Throughput Analyses of Cancer Organoids
R21CA267260 ARMITAGE, BRUCE A (contact); ZHANG, HUAIYING  Fluorescent gammaPNA Miniprobes for Imaging Telomeric RNA
R33CA267226 DRAKE, RICHARD R Targeted Isolation and Identification of Sialylated Glycoproteins in Cancer Tissues, Cells and Biofluids
R21CA267012 SNYDER, JOSHUA CLAIR Mouse Paint: A massively combinatorial approach for illuminating tumor heterogeneity in True Color
R21CA269103 BLAINEY, PAUL CLARK Stitch-seq for genome-wide pooled genomic screening with RNA-seq readout
R33CA267221 NORMAN, THOMAS MAXWELL (contact); LOWE, SCOTT W Systematic characterization of cancer variants using single-cell functional genomics
R33CA269015 ADEY, ANDREW  Accessible high-throughput single-cell genome sequencing
R21CA261775 LIN, QIAO  A Practical Approach to Tumor-Specific Aptamers for B-Cell Hematologic Malignancies
R33CA258012 KARGINOV, ANDREI V (contact); REHMAN, JALEES  Optogenetic Control of Tumor Initiation and Tumor Progression in vivo
R33CA269094 MOELLERING, RAYMOND E Single-Cell Protein Activity Profiling in Breast Cancer Cells and Tissues
R21CA267245 SHIBATA, DARRYL K Photolithographic Tumor DNA Isolation
R21CA269091 BORGES, CHAD R Plate reader assays to forensically assess exposure of plasma and serum to thawed conditions
R33CA261696 MERAJVER, SOFIA DIANA (contact); OLIVER, CHRISTOPHER RYAN Advanced development and validation of an in vitro platform to phenotype brain metastatic tumor cells using artificial intelligence
R33CA269100 CHIU, BRIAN C-H (contact); ZHANG, WEI  A highly sensitive linear amplification based DNA methylation profiling technique for clinical cancer research
R21CA269099 YAKOVLEV, VLADISLAV V (contact); BEREZIN, MIKHAIL Y Molecular and cellular imaging of bone biopsies using AI augmented deep UV Raman microscopy
R21CA272014 SALIPANTE, STEPHEN J Efficient, cost-effective, and ultrasensitive sequencing of somatic mutations
R33CA259451 NAEGLE, KRISTEN M A synthetic toolkit for the recombinant production of tyrosine phosphorylated proteins and peptides
R21CA257816 COUNTER, CHRISTOPHER M (contact); ABBRUZZESE, JAMES L Adapting K-MDS to detect KRAS-mutant ctDNA
R21CA257942 GIBBS, SUMMER LYNNE A Novel Fluorescence Imaging Platform to Predict Response to Combinatorial Tyrosine Kinase Inhibitors
R21CA261642 NABA, ALEXANDRA  (contact); GAO, YU  Enhanced mass-spectrometry-based approaches for in-depth profiling of the cancer extracellular matrix
R21CA261643 TANG, SINDY KAM-YAN A micro-dissection platform for generating uniform-sized patient-derived tumor organoids (PDOs) for personalized cancer therapy
R21CA272326 KELLY, RYAN T In-depth and label-free proteome profiling of hundreds of single cells per day
R21CA272351 SOPER, STEVEN ALLAN Molecular Sub-typing Breast Cancer Patients using a Liquid Biopsy
R33CA267219 LANDAU, DAN  Expanding the GoT toolkit to link single-cell clonal genotypes with protein, transcriptomic, epigenomic and spatial phenotypes
R33CA267258 LEE, ABRAHAM P (contact); AGRAWAL, ANSHU  Microfluidic Precision Engineered Artificial Antigen Presenting Cells for Cancer Immunotherapy
R33CA272321 WANG, TZA-HUEI JEFF  (contact); PISANIC II, THOMAS RUSSELL A low-cost, multiplexed digital high resolution melt platform for DNA methylation-based detection and identification of cancers in liquid biopsies
R33CA272357 PAN, TAO  (contact); BISSONNETTE, BRUCE MARC; SHOGAN, BENJAMIN  Transfer RNA sequencing and application to cancer research and clinics
R33CA277820 WEISSLEDER  MD  PHD, RALPH  Bioorthogonal probe development for highly parallel in vivo imaging
R33CA278392 KLEIN, ALLON MOSHE (contact); MAZUTIS, LINAS  Micro-capsules for versatile multiplexed cytometry
R61CA278445 DHAKAL, SOMA  Single-Molecule High-Confidence Detection of miRNA Cancer Biomarkers
R61CA278531 SHIRURE, VENKTESH  Microfluidic technology to isolate tumoricidal T-cells from peripheral blood
R33CA278393 VAN GALEN, PETER  (contact); SANKARAN, VIJAY GANESH Clonal analysis of cancer by mitochondrial DNA barcoding
R33CA278510 DUNCAVAGE, ERIC J (contact); SPENCER, DAVID H A Rapid and Comprehensive Approach for Clinical Genomic Profiling in Lung Cancer
R61CA278558 YAN, HAO  (contact); HARIADI, RIZAL FAJAR High-throughput, purification-free, and ultrasensitive transmembrane nanosensor arrays for digital counting of microRNA biomarkers of intact exosomes
R33CA278469 JI, HANLEE P Single cell modeling of cancer mutations
R33CA278544 LEVENSON, RICHARD M CoreView and FIBI for rapid-onsite evaluation and molecular profiling of core-needle breast biopsies.
R33CA278551 ISSADORE, DAVID AARON (contact); CARPENTER, ERICA  Combining Machine Learning and Nanofluidic Technology for The Multiplexed Diagnosis of Pancreatic Adenocarcinoma
R61CA278398 GAO, XIAOJING J (contact); WINSLOW, MONTE MEIER Program the Immune System against RAS-driven Cancer
R61CA278459 PRATX, GUILLEM  A Novel Assay to Individualize Resensitization of Iodine-Refractory Thyroid Cancer
R61CA278559 LU, YUE  Vesicle Epitope Transcript sequencing (VET-seq): Droplet-based Multiomic Profiling Platform for Single Vesicle Analysis
R33CA272271 CUNNINGHAM, BRIAN T (contact); MANSFIELD, AARON SCOTT; WANG, XING  Rapid, simple, and ultrasensitive quantitation of KRAS ctDNA at the point of care using CRISPR/Cas amplification and digital resolution biosensor microscopy
R33CA272331 MURETTA, JOSEPH M (contact); GORDON, WENDY RYAN Engineering Protein Modulators of Notch Activation for T-cell immunotherapy
R33CA281702 CHEN, SIDI  Advanced development of composite gene delivery and CAR engineering systems
R33CA281802 LABAER, JOSHUA  Multiplex In-Solution Protein Array (MISPA) for high throughput, quantitative, early profiling of pathogen-induced head and neck
R33CA281875 BRUDNO, YEVGENY  MASTER Scaffolds for Rapid, Single-Step Manufacture and Prototyping of CAR-T cells
R33CA281918 YE, LI  (contact); CRAVATT, BENJAMIN F A platform to identify in vivo targets of covalent cancer drugs in 3D tissues
R61CA278402 BRAVO CORDERO, JOSE JAVIER  Intersectional genetics-based biosensors for dormant cancer cells
R61CA281657 LUKER, GARY D Integrated Imaging Tools for Intercellular Chemokine Signalling
R61CA281667 FERNANDEZ, FACUNDO MARTIN Triboelectric Ambient Mass Spectrometry Imaging of Renal Cell Carcinomas
R61CA281807 HACOHEN, NIR  Development of methods for highly multiplexed quantification of cancer proteomes using large-scale nanobody libraries
R61CA278452 SHAH, NEEL H A Generalizable Photo-Crosslinking Strategy to Identify Tyrosine Phosphatase Substrates
R61CA281795 CAMPAGNOLA, PAUL J (contact); YESILKOY, FILIZ  A novel multimodal ECM analysis platform for tumor characterization combining morphological and spectrochemical tissue imaging approaches.
R33CA281602 MEYER, KATHRYN D A High-Throughput Screening Platform to Discover RNA Methylation Inhibitors
R21CA251052 SHVETS, GENNADY Phenotypic assay for drug discovery and personalized medicine based on real-time vibrational spectroscopy enhanced by plasmonic metasurfaces