Active Projects
Actv | PI Name(s) All | Title |
---|---|---|
R33 | TEWARI, MUNEESH (contact); WALTER, NILS G | Optimization and Validation of Single-Molecule Kinetic Fingerprinting Technology for Rapid, Ultra-Specific Detection of Cancer Mutations |
R33 | KONRY, TANIA TALI (contact); EVENS, ANDREW M; HUANG, TONY JUN | Determining treatment sensitivity in B cell lymphoma by novel microfluidics-based NK cell immunogenicity platform |
R21 | NAEGLE, KRISTEN M | A molecular toolkit for the production of tyrosine phosphorylated proteins |
R21 | NECHAEV, SERGEI | Transcriptome profiling of highly degraded specimens through global analysis of short RNA fragments. |
R21 | BROCK, AMY | High resolution cell lineage tracking and isolation |
R21 | PAULOVICH, AMANDA G | Validation of a disposable biospecimen collection system with integral refrigeration for preserving the phosphoproteome |
R33 | WANG, YINGXIAO | Multiplex FRET Imaging of Kinase-Epigenome Interregulations in Live Cancer Cells |
R33 | IBRAHIM, YEHIA | High Resolution High Throughput Proteomics Platform for Cancer Research |
R21 | MALMSTADT, NOAH (contact); ROBERTS, RICHARD W | A Target-Directed Reagent Pipeline via Microfluidic mRNA Display |
R33 | ZENG, YONG (contact); GODWIN, ANDREW K; SAMUEL, GLENSON | Integrated exosomes profiling for minimally invasive diagnosis and monitoring of cancer |
R33 | BROWN, BRIAN D | Pro-Codes: A novel vector and cell barcoding technology |
R33 | SCHRUM, ADAM G | Multiplex matrix ELISA for T cell protein-interaction networks in cancer |
R21 | ROYZEN, MAKSIM | Development of Catch and Release Approach for Multi-Drug Local Delivery of Chemotherapies |
R21 | GULLEY, MARGARET L | EndoGenus Toolkit: A Biometric Method for Absolute Quantification of Tumor Markers by Massive Parallel Sequencing |
R21 | FU, XIAO-AN | A microreactor chip platform for quantitative analysis of unsaturated aldehydes in exhaled breath |
R33 | BORGES, CHAD R | Validation and Advanced Development of Albumin Oxidizability as a Marker of Plasma/Serum Integrity |
R21 | SHI, TUJIN | An ultrasensitive targeted mass spectrometry system for proteomics analysis of single cells |
R21 | VAN DEVENTER, JAMES ALLEN | Discovering hybrid inhibitors for tumor microenvironment disruption |
R21 | ENGLER, ADAM JEFFREY | Developing Adhesome Technology as a Physical Marker of Highly Metastatic Cells |
R33 | LIU, YANG | High-throughput super-resolution imaging of chromatin structures at different epigenetic states |
R33 | LU, JUN | CRISPR-based Enhanced Molecular Chipper Technology for Identifying Functional Noncoding Elements in Cancer |
R21 | KARGINOV, ANDREI V (contact); REHMAN, JALEES | Optogenetic tools for the dissection of oncogenic signaling mediated by kinases |
R21 | SMITH, LLOYD M | Novel NeuCode Tagging Reagents for Identification and Quantification of Intact Proteoforms in Cancer Tissues |
R33 | INCE, TAN A | Live Tumor Culture Core and Tissue Specific Culture (TSC) System for Human Cancers |
R33 | SALIPANTE, STEPHEN J | Advanced development and validation of genome-scale molecular diagnostics for microsatelliteinstability using targeted molecular counting methods |
R21 | FIELDS, RYAN C | Advancing Cancer Biology, Diagnostics and Therapeutics Outside of the Patient: Creation of a Novel, Autologous, Ex Vivo, Vascularized Model of the Tumor Microenvironment |
R21 | ROBLES, FRANCISCO E | Stimulated Raman scattering spectroscopic optical coherence tomography (SRS-SOCT) for label-free molecular imaging of brain tumor pathology |
R21 | BRENT, ROGER | Precision controllers of mammalian gene expression |
R33 | CIMA, MICHAEL J | Advanced development and validation of microdevices for high-throughput in situ drug sensitivity testing in tumors |
R21 | VAN DAM, ROBERT MICHAEL | High-throughput radiochemistry platform for accelerated discovery and development of novel PET imaging agents for cancer |
R33 | CHENG, JI-XIN | Quantitative SRS Imaging of Cancer Metabolism at Single Cell Level |
R21 | MOHS, AARON M | Tunable Fluorescent Organic Nanoparticles for Cancer Imaging Applications |
R33 | WALTER, MATTHEW J (contact); DUNCAVAGE, ERIC J | TARGETED SINGLE-MOLECULE SEQUENCING ASSAY INCORPORATING MOLECULAR BARCODES |
R33 | PARKER, LAURIE L | Fluorescence lifetime-based single fluorophore biosensors of post-translational modification enzyme activity |
R33 | PATTENDEN, SAMANTHA GAIL (contact); DAVIS, IAN J; DAYTON, PAUL A | The application of Enhanced Cavitation to enable DNA and Chromatin Extraction from Archived Tissues |
R21 | KRON, STEPHEN J | Tag-ChIP-MS for analysis of chromatin-level regulation of DNA repair |
R33 | LEVENSON, RICHARD M | Cancer histology and QC via MUSE: Sample-sparing UV surface-excitation microscopy |
R21 | ABBOTT, KAREN L. | Novel Platform linking cancer-specific glycosylation with cell signaling outcomes |
R21 | MAILLOUX, ADAM WILLIAM | Autohistomagnetic Isolation of Tumor-reactive T-cells |
R21 | SCHIBEL, ANNA | Microsatellite Sequencing to Enable Cancer Genotyping |
R33 | LEVINSON, NICHOLAS MARK | Time-resolved FRET-based allostery sensors for any protein kinase drug target |
R33 | HIGGINSON, DANIEL | Comprehensive breakpoint analyses for simultaneous quantification of all DNA double strand break repair pathways |
R33 | HALL, ADAM ROGER | Detecting diverse nucleic acid biomarkers of cancer with solid-state nanopores |
R33 | WANG, SIYUAN (contact); MUZUMDAR, MANDAR DEEPAK | Multiplexed imaging of chromatin folding and RNA profiles in cancer |
R21 | GUPTA, GAUTAM | Bio CaRGOS: Capture and release gels for optimized storage of Cancer Biospecimens |
R21 | LIANG, FU-SEN | Spatiotemporal Epitranscriptome Editing Technology |
R33 | BHATNAGAR, PARIJAT | T-cell Biofactories for targeting extracellular matrix |
R21 | LI, WEI | Fractionation and Profiling of Heterogeneous Circulating Tumor Cells Using a Hyperuniform- Structured Microchip |
R33 | RECHT, MICHAEL | High-Throughput Screening Platform for Cancer Drug Discovery |
R33 | HASHAM, MUNEER GULAMHUSEIN | Impact of Genetic Diversity on Human Xenograft Tumor Growth |
R21 | TEWARI, MUNEESH (contact); JOHNSON-BUCK, ALEXANDER EDMUND; WALTER, NILS G | Highly specific, amplification-free, single-molecule counting of rare methylated DNA cancer biomarkers |
R33 | Wang, Shaopeng | A Virion-Display Oscillator Array and Detection Platform for Quantification of Transmembrane Protein Binding Kinetics |
R21 | SEELIG, GEORG (contact); WU, DAVID | High-resolution spatial transcriptomics through light patterning |
R33 | CHEN, FEI (contact); REGEV, AVIV ; RODIG, SCOTT J | Clinical implementations of spatial transcriptomics in tumors |
R33 | FAN, RONG (contact); LU, JUN | High-throughput single-cell co-sequencing of small and large RNAs to identify molecular circuitry in cancer |
R21 | CICERONE, MARCUS T | Label-Free Cell-Resolved Metabolomics for Tumor Microscopy |
R21 | HUR, SOOJUNG CLAIRE | Development of a microfluidic primary cell editing platform (pCEP) for personal gene therapy |
R33 | WEI, CHIA-LIN (contact); VERHAAK, ROEL GW | Advancing Ultra Long-read Sequencing and Chromatin Interaction Analyses for Chromosomal and Extrachromosomal Structural Variation Characterization in Cancer |
R21 | MANALIS, SCOTT R | Building microenvironment-containing organoids from patient samples with single-cell precision |
R33 | DE VLAMINCK, IWIJN (contact); BRITO, ILANA LAUREN; ZIPFEL, WARREN R | Spatially Resolved Metagenomics to Explore Tumor-Microbiome Interactions in Human Colorectal Cancer |
R33 | SOPER, STEVEN ALLAN (contact); AUGUST, KEITH | Increased Sensitivity of Minimal Residual Disease Monitoring using Peripheral Blood in Pediatric Patients with Acute Lymphoblastic Leukemia |
R21 | KEUNG, ALBERT | Intracellular CRISPR gRNA assembly for massively multiplexed, one pot, (epi)genetic screening |
R21 | O'NEILL, RACHEL | Development and Utilization of Splice-specific Antibodies |
R21 | MONTAGNA, CRISTINA (contact); LENZ, JACK R | Development of a high-resolution mapping platform for HPV DNA integration in premalignant lesions |
R21 | IM, HYUNGSOON | Nano-plasmonic technology for high-throughput single exosome analyses |
R33 | SCHIAVINATO EBERLIN, LIVIA | Advanced Development of the MasSpec Pen for Cancer Diagnosis and Surgical Margin Evaluation |
R33 | VAN DAM, ROBERT MICHAEL | Optimization and validation of integrated microscale technologies for low-cost, automated production of PET molecular imaging tracers for cancer research |
R21 | ANDRES-MARTIN, LAURA | Establishing efficient technologies for ovarian cancer organoid derivation from fresh tumor resections |
R21 | ALEXANDRAKIS, GEORGIOS | Nanotechnology Enabled Selection of MHC-Peptide Ligands to Personalize Cancer Therapy |
R21 | HATTORI, TAKAMITSU | Rational generation of high-performance recombinant antibodies to post-translational modifications |
R33 | KETTENBACH, ARMINJA NADINE (contact); GERBER, SCOTT A | Activity based profiling of Phosphoprotein phosphatases in cancer using mass spectrometry-based proteomics |
R33 | YANG, JENNY J | Multi-color Mapping of Cancer Molecular Signatures and Tumor microenvironment |
R33 | TAVANA, HOSSEIN (contact); LUKER, GARY D | A High Throughput Human Tumor Modeling Technology for Cancer Drug Discovery |
R21 | KENTSIS, ALEX | Multi-dimensional targeted mass spectrometry technology for pathway-scale functional proteomics |
R33 | SCHNECK, JONATHAN P | A high-throughput nanoparticle assay to characterize cancer neoepitope-specific T cells |
R21 | WARREN, CHRISTOPHER L (contact); OZERS, MARY SZATKOWSKI | SNAP-X: Development of a Mutagenesis Strategy and High Density Protein Array to Comprehensively Display Protein Variants |
R21 | SINGAMANENI, SRIKANTH (contact); MORRISSEY, JEREMIAH J | METAL-ORGANIC FRAMEWORK AS PROTECTIVE COATING FOR CANCER BIOSPECIMEN PRESERVATION |
R21 | KIM, HYUN JUNG | A personalized colorectal cancer-on-a-chip for assessing tumor-microbiome crosstalk |
R21 | MARTO, JARROD A (contact); BUHRLAGE, SARA J | Tools for DUB Drug Discovery |
R33 | JIANG, NING | An integrated therapeutic T cell receptor screening platform for adoptive cell therapy in cancer |
R21 | ZHU, YAZHEN (contact); AGOPIAN, VATCHE ; TSENG, HSIAN-RONG | Click Chemistry-Mediated Microfluidic Sorting for HCC CTCs |
R33 | CHEN, SIDI | Rapidly scalable platforms for direct in vivo screening of functional drivers in lethal cancers |
R21 | WEISSLEDER, RALPH | Single Circulating Vesicle Analysis for Early Cancer Detection |
R21 | GARBER, MANUEL | A modular, customizable sequencing system for simultaneous genotyping and transcript analysis in single cells |
R21 | BHATNAGAR, PARIJAT | T-cell Biofactories for targeting interstitial fluid pressure |
R33 | BREUNIG, JOSHUA JOHN | GESTALT Barcoding and Single-cell Transcriptomics of Tumor Cell Evolution in Personalized Tumor Models |
R21 | SEIBEL, ERIC J | Rapid Needle Biopsy Assessment at Point of Care to advance personalized cancer therapy |
R33 | COOKS, ROBERT GRAHAM (contact); CHAICHANA, KAISORN LEE; QUINONES-HINOJOSA, ALFREDO | Advanced Development of Desorption Electrospray Ionization Mass Spectrometry for Intraoperative Molecular Diagnosis of Brain Cancer using Pathology Biopsies |
R21 | WU, YUN (contact); GAN, QIAOQIANG | Exosome-Protein-microRNA-OneStop (Exo-PROS) biosensor: a new liquid biopsy for cancer screening and early detection |
R33 | LEI, YUGUO | A Single Conical Tube Device for Precision CAR-T Cells Manufacturing |
R33 | FIOLKA, RETO PAUL | Multiscale microscope for 3D cancer imaging in model organisms and organoids |
R21 | YAMAMOTO, KEITH ROBERT (contact); KROGAN, NEVAN J | CasCUT&RUN: An in vivo method to analyze locus-specific protein complexes driving transcription of target genes in cancer |
R21 | REVZIN, ALEXANDER | A microfluidic cell culture platform for personalizing pancreatic cancer therapies |
R21 | ANGEL, PEGGY M | Enzymatic Tools for 2D Tissue Localized and Deeper Proteomic Sequencing of Cancer Stromal Proteins |
R21 | HUANG, XIAOHUA | Technology for measuring telomere length of individual chromosomes of single cancer cells |
R21 | SKARDAL, ALEKSANDER (contact); STROWD, ROY ERVIN | Predicting Tumor Heterogeneity Evolution After Therapy In Patient-Derived Ex Vivo Glioblastoma Organoids |
R21 | SHVETS, GENNADY | Phenotypic assay for drug discovery and personalized medicine based on real-time vibrational spectroscopy enhanced by plasmonic metasurfaces |
R21 | FOLCH, ALBERT | High-content functional cancer drug testing on micro-cuboidal tumor dissections |
R33 | SPICER, TIMOTHY PATRICK | Advanced Development and Validation of 3 Dimensional Spheroid Culture of Primary Cancer Cells using Nano3D Technology |
R33 | WEISS, GREGORY A | Monitoring Recurrent Bladder Cancer with Electro-Phage Biosensors |
R21 | GAMCSIK, MICHAEL | High-Throughput Screening Under Static or Dynamic Hypoxia |
R33 | LIN, QIAO | Validating Rapid Microfluidic Isolation of Personalized Aptamers for Monitoring Minimal Residual Disease in Multiple Myeloma |
R33 | WU, YUN | Noninvasive detection of circulating RNAs for lung cancer early detection and prognosis |