| R33CA291301 |
Jungwoo Lee |
Develop and validate demineralized bone paper-based human bone metabolic and senolytic assays |
| R61CA291117 |
Elisa Biondi |
Evolved Molecules that Destroy Cancer Relevant Proteins |
| R33CA272339 |
John Yates III |
3D Proteomics at Single Cell Resolution with Covalent Protein Painting (CPP) |
| R33CA287046 |
Ji-Xin Cheng |
Bio-orthogonal Mid-Infrared Photothermal Imaging of Cancer Metabolism |
| R33CA291185 |
Darryl Bornhop |
Quantification of molecular interactions across the matrix spectrum enables cancer research |
| R61CA287408 |
Yanxiang Deng |
Spatially resolved multi-omics sequencing of FFPE tissues at cellular level |
| R61CA291201 |
Jeffrey Ishizuka |
Multiplexed, Continuous Reporting of Gene Expression via CRISPR-mediated Transcriptional Activation |
| R61CA291212 |
Sapun Parekh; James Tunnell |
Precision Tumor Sampling of Melanoma Using Laser Microbiopsy |
| R61CA291202 |
Huiqing Jane Zhou; Jia Niu |
Development of A Directed Evolution Platform for RNA Methyltransferases. |
| R33CA291199 |
Fei Chen |
A platform for multi-modal single nucleus spatial genomics for molecular tumor analysis |
| R33CA291197 |
Ahmet Coskun |
Spatial protein-protein interaction networks in situ by multiplexed proximity ligation |
| R33CA291125 |
Tania Tali Konry |
Microphysiological platform for analyzing multiple myeloma's tumor microenvironment enabling immunotherapy assessment and drug screening. |
| R33CA287135 |
David Issadore |
High Throughput Digital Droplet Assays for Ultrasensitive Multimodal (DNA RNA and Protein) Diagnostics |
| R61CA287026 |
Wilhelm Haas; Lecia Sequist |
A Real-Time AI-Driven High-Throughput Proteomics Data Acquisition Method for Clinical Applications |
| R33CA281919 |
Gloria Sheynkman; Stephen Yi |
An integrated functional proteomics platform for accelerated discovery of isoform-specific determinants of cancer |
| R33CA281918 |
Li Ye; Benjamin Cravatt |
A platform to identify in vivo targets of covalent cancer drugs in 3D tissues |
| R33CA281875 |
Yevgeny Brudno |
MASTER Scaffolds for Rapid, Single-Step Manufacture and Prototyping of CAR-T cells |
| R61CA281807 |
Nir Hacohen |
Development of methods for highly multiplexed quantification of cancer proteomes using large-scale nanobody libraries |
| R33CA281802 |
Joshua Labaer |
Multiplex In-Solution Protein Array (MISPA) for high throughput, quantitative, early profiling of pathogen-induced head and neck |
| R61CA281795 |
Paul Campagnola; Filiz Yesilkoy |
A novel multimodal ECM analysis platform for tumor characterization combining morphological and spectrochemical tissue imaging approaches. |
| R33CA281794 |
Hyungsoon Im |
Nano-CRISPR extracellular vesicle sensing system for longitudinal tumor monitoring |
| R61CA281785 |
Parijat Bhatnagar |
Bioreactor for Manufacturing Chemotactically Competent Immune Cell Therapies |
| R33CA281702 |
Sidi Chen |
Advanced development of composite gene delivery and CAR engineering systems |
| R61CA281667 |
Facundo Fernandez |
Triboelectric Ambient Mass Spectrometry Imaging of Renal Cell Carcinomas |
| R61CA281657 |
Gary Luker |
Integrated Imaging Tools for Intercellular Chemokine Signalling |
| R33CA281602 |
Katherine Meyer |
A High-Throughput Screening Platform to Discover RNA Methylation Inhibitors |
| R33CA278564 |
Joshua Breunig |
Enabling in vivo barcoded single-cell multiomics-compatible genome-wide screens in personalized tumor models using defined-copy somatic transgenesis |
| R61CA278559 |
Yue Lu |
Vesicle Epitope Transcript sequencing (VET-seq): Droplet-based Multiomic Profiling Platform for Single Vesicle Analysis |
| R61CA278558 |
Hao Yan; Rizal Hariadi |
High-throughput purification-free and ultrasensitive transmembrane nanosensor arrays for digital counting of microRNA biomarkers of intact exosomes |
| R33CA278551 |
David Issadore; Erica Carpenter |
Combining Machine Learning and Nanofluidic Technology for The Multiplexed Diagnosis of Pancreatic Adenocarcinoma |
| R33CA278544 |
Richard Levenson |
CoreView and FIBI for rapid-onsite evaluation and molecular profiling of core-needle breast biopsies. |
| R61CA278536 |
Paul Clark Blainey |
Profiling and perturbing the inheritance of drug-induced metabolic states in cancer with Inheritance-Seq |
| R61CA278531 |
Venktesh Shirure |
Microfluidic technology to isolate tumoricidal T-cells from peripheral blood |
| R61CA278518 |
Torsten Wittmann |
Quantitative analysis and manipulation of chromosome dynamics in cancer organoids |
| R33CA278510 |
Eric Duncavage; David Spencer |
A Rapid and Comprehensive Approach for Clinical Genomic Profiling in Lung Cancer |
| R61CA278503 |
Philipp Oberdoerffer |
Proximity epigenomics for context-specific analysis of complex chromatin features |
| R33CA278469 |
Hanlee Ji |
Single cell modeling of cancer mutations |
| R61CA278459 |
Guillem Pratx |
A Novel Assay to Individualize Resensitization of Iodine-Refractory Thyroid Cancer |
| R61CA278458 |
Robert Rostomily; Francois St-Pierre |
A multiplexed high-throughput platform to report pharmacologic alteration of cancer stem cell membrane potential and cell cycle state |
| R61CA278452 |
Neel Shah |
A Generalizable Photo-Crosslinking Strategy to Identify Tyrosine Phosphatase Substrates |
| R61CA278450 |
Sarah Heilshorn |
Tumor Metabolic Profiling by Multiplexed Single-Cell Lipid and mRNA Imaging |
| R61CA278449 |
Jarrod Marto; Justin Kim |
New Chemical Tools for Covalent Drug Discovery |
| R61CA278445 |
Soma Dhakal |
Single-Molecule High-Confidence Detection of miRNA Cancer Biomarkers |
| R33CA278429 |
Jonathan Schneck |
Identification of cancer neoepitope-specific T cells using novel high-throughput hydrogel based platforms |
| R61CA278402 |
Jose Javier Bravo-Cordero |
Intersectional genetics-based biosensors for dormant cancer cells |
| R61CA278398 |
Xiaojing Gao; Monte Meier Winslow |
Program the Immune System against RAS-driven Cancer |
| R33CA278393 |
Peter Van Galen; Vijay Ganesh Sankaran |
Clonal analysis of cancer by mitochondrial DNA barcoding |
| R33CA278392 |
Allon Klein; Linas Mazutis |
Micro-capsules for versatile multiplexed cytometry |
| R33CA277820 |
Ralph Weissleder |
Bioorthogonal probe development for highly parallel in vivo imaging |
| R33CA272357 |
Tao Pan; Bruce Bissonnette; Benjamin Shogan |
Transfer RNA sequencing and application to cancer research and clinics |
| R21CA272351 |
Steven Soper |
Molecular Sub-typing Breast Cancer Patients Using a Liquid Biopsy |
| R21CA272345 |
David Knowles |
A CRISPR/Cas13 approach for identifying individual transcript isoform function in cancer |
| R33CA272339 |
John Yates III |
3D Proteomics at Single Cell Resolution with Covalent Protein Painting (CPP) |
| R33CA272331 |
Joseph Muretta; Wendy Gordon |
Engineering Protein Modulators of Notch Activation for T-cell immunotherapy |
| R21CA272326 |
Ryan Kelly |
In-depth and label-free proteome profiling of hundreds of single cells per day |
| R33CA272321 |
Tza-Huei Jeff Wang; Thomas Pisanic II |
A low-cost, multiplexed digital high resolution melt platform for DNA methylation-based detection and identification of cancers in liquid biopsies |
| R33CA272271 |
Brian Cunningham; Aaron Mansfield; Xing Wang |
Rapid simple and ultrasensitive quantitation of KRAS ctDNA at the point of care using CRISPR/Cas amplification and digital resolution biosensor microscopy |
| R21CA272014 |
Stephen Salipante |
Efficient cost-effective and ultrasensitive sequencing of somatic mutations |
| R21CA269103 |
Paul Clark Blainey |
Stitch-seq for genome-wide pooled genomic screening with RNA-seq readout |
| R33CA269100 |
Brian C-H Chiu; Wei Zang |
A highly sensitive linear amplification based DNA methylation profiling technique for clinical cancer research |
| R21CA269099 |
Vladislav Yakovlev; Mikhail Berezin |
Molecular and cellular imaging of bone biopsies using AI augmented deep UV Raman microscopy |
| R33CA269094 |
Raymond Moellering |
Single-Cell Protein Activity Profiling in Breast Cancer Cells and Tissues |
| R21CA269091 |
Chad Borges |
Plate reader assays to forensically assess exposure of plasma and serum to thawed conditions |
| R33CA269015 |
Andrew Adey |
Accessible high-throughput single-cell genome sequencing |
| R21CA267260 |
Bruce Armitage; Huaiying Zhang |
Fluorescent gammaPNA Miniprobes for Imaging Telomeric RNA |
| R33CA267258 |
Abraham Lee; Anshu Agrawal |
Microfluidic Precision Engineered Artificial Antigen Presenting Cells for Cancer Immunotherapy |
| R21CA267245 |
Darryl Shibata |
Photolithographic Tumor DNA Isolation |
| R33CA267226 |
Richard Drake |
Targeted Isolation and Identification of Sialylated Glycoproteins in Cancer Tissues Cells and Biofluids |
| R21CA267222 |
Hakho Lee |
3D Fourier Imaging System for High Throughput Analyses of Cancer Organoids |
| R33CA267221 |
Thomas Norman; Scott Lowe |
Systematic characterization of cancer variants using single-cell functional genomics |
| R33CA267219 |
Dan Landau |
Expanding the GoT toolkit to link single-cell clonal genotypes with protein, transcriptomic, epigenomic and spatial phenotypes |
| R21CA267012 |
Joshua Snyder |
Mouse Paint: A massively combinatorial approach for illuminating tumor heterogeneity in True Color |
| R21CA263147 |
Rohit Bhargava |
Spectroscopy Assisted Laser Microdissection |
| R21CA261775 |
Qiao Lin |
A Practical Approach to Tumor-Specific Aptamers for B-Cell Hematologic Malignancies |
| R21CA261737 |
Sarah Hainer; Yi Shi |
Using nanobodies to increase the sensitivity and resolution of chromatin profiling through uliCUT&RUN |
| R21CA261734 |
Alptekin Aksan |
Novel cryopreservation method for stabilization of manufactured therapeutic cells |
| R33CA261726 |
Ji-Xin Cheng |
Mapping Cancer Metabolism by Mid-infrared Photothermal Microscopy |
| R33CA261696 |
Sofia Merajver; Jianping Fu |
Advanced development and validation of an in vitro platform to phenotype brain metastatic tumor cells using artificial intelligence |
| R21CA261643 |
Sindy Tang |
A micro-dissection platform for generating uniform-sized patient-derived tumor organoids (PDOs) for personalized cancer therapy |
| R21CA261642 |
Alexandra Naba, Yu Gao |
Enhanced mass-spectrometry-based approaches for in-depth profiling of the cancer extracellular matrix |
| R33CA259451 |
Kristen Naegle |
A synthetic toolkit for the recombinant production of tyrosine phosphorylated proteins and peptides |
| R21CA258019 |
Kai Chen; Charles McKenna |
Novel Bisphosphonate PET Probes for Myeloma Bone Disease |
| R33CA258016 |
Xuefeng Liu |
Validating Urine Derived Cancer Cells (UDCC) -- Non-Invasive and Living Liquid Biopsies -- in Bladder Cancer Clinics |
| R21CA258013 |
Shivani Nautiyal |
Device for Preservation of Cell Free RNA in Saliva |
| R33CA258012 |
Andrei Karginov; Jalees Rehman |
Optogenetic Control of Tumor Initiation and Tumor Progression in vivo |
| R21CA258008 |
Giuliano Scarcelli; Konstantinos Konstantopoulos; Stuart Martin |
Stimulated Brillouin Flow Cytometry for biomechanical assessment of metastatic potential |
| R21CA257980 |
Ron Weiss; Carlo Maley |
A cell-cycle induced genetic recorder for simultaneous recovery of cell divisions and lineage |
| R21CA257942 |
Summer Gibbs |
A Novel Fluorescence Imaging Platform to Predict Response to Combinatorial Tyrosine Kinase Inhibitors |
| R33CA257878 |
Anders Hansen |
Super-resolution microscopy for dynamic analysis of focal enhancer amplifications in cancer |
| R21CA257864 |
Alan Boyle |
High-throughput inverted reporter assay for characterization of silencers and enhancer blockers |
| R21CA257816 |
Christopher Counter |
Adapting K-MDS to detect KRAS-mutant ctDNA |
| R21CA256128 |
Michael Deininger |
A Bioluminescent Assay for Direct Measurement of Sirtuin Activity in Cancer Cells |
| R33CA256112 |
Wei Wei |
Liquid biopsy-based toolkits for neoantigen and cognate TCR discovery for cancer immunotherapy |
| R33CA256102 |
Joel Greenberg |
Multimodality X-ray transmission and diffraction scanner for molecular analysis of cancer specimens |
| R33CA256086 |
Ning Jenny Jiang; Amy Brock |
A streamlined high-throughput platform for validation of cancer antigen presentation and isolation of cancer antigen reactive T cells |
| R21CA256082 |
Liron Bar-Peled |
Chemical Proteomic Identification of Druggable Oncogenic Transcription Factors |
| R21CA255979 |
Vladimir Didenko |
In situ assay imaging nuclear RNA exosome activity for cancer studies |
| R33CA252158 |
Yong Zeng; Liang Xu |
Integrative Functional Profiling of Tumor-Derived Extracellular Vesicles |
| R21CA251043 |
Shuichi Hoshika |
High Quality Proteins with Multiple Post Translational Modifications |
| R21CA251027 |
Rebecca Schulman |
Secretion responsive Hydrogels for Identification of Functional single T cells (SHIFT) |
| R21CA250999 |
Chad Borges |
Aliquot-level visual indicators of biospecimen exposure to thawed conditions |
| R33CA247700 |
Hanlee Ji |
Multimodal iterative sequencing of cancer genomes and single tumor cells |
| R33CA246448 |
Adam Hall |
Detecting diverse nucleic acid biomarkers of cancer with solid-state nanopores |
| R21CA240185 |
Wei Li |
Fractionation and Profiling of Heterogeneous Circulating Tumor Cells Using a Hyperuniform- Structured Microchip |
| R21CA236665 |
Maria Santore |
Paper-based Breastmilk Collection System for Facile In-Home Use |
| R33CA225549 |
Hossein Tavana; Gary Luker |
A High Throughput Human Tumor Modeling Technology for Cancer Drug Discovery |
| R21CA225493 |
Muneesh Tewari; Nils Walter |
Highly specific, amplification-free, single-molecule counting of rare methylated DNA cancer biomarkers |
| R21CA251052 |
Gennady Shvets |
Phenotypic assay for drug discovery and personalized medicine based on real-time vibrational spectroscopy enhanced by plasmonic metasurfaces |
