Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #56

serial: '56'
sid: '150482'
uuid: 94a1d7ac-953d-4af3-9525-a67f53dac576
uri: '/nci/ccdisymposium/abstract?cid=eb_govdel_ccdi_events'
created: '1756750757'
completed: '1756750757'
changed: '1756750757'
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langcode: en
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data:
  authors_:
    - add_author_degree: 'BSc Hons Life Sciences (Biotechnology, Microbiology, Biochemistry) '
      add_author_first_name: 'Priya Rithika'
      add_author_last_name: Vella
      add_author_middle: ''
      add_author_organization: 'Malla reddy university'
  abstract: |
    Angiogenesis is a fundamental process driving tumor progression, metastasis, and therapeutic resistance in both adult and pediatric cancers. In childhood malignancies, dysregulated vascular growth not only supports tumor expansion but also contributes to the formation of an immunosuppressive tumor microenvironment. Targeting angiogenesis through inhibition of vascular endothelial growth factor (VEGF) signaling and vessel normalization has emerged as a promising therapeutic strategy. However, clinical translation in pediatric oncology has been limited by insufficient drug accumulation, systemic toxicities, and heterogeneous patient responses. Advances in nanotechnology now enable the design of precision nanoformulations that selectively modulate abnormal vasculature while minimizing adverse effects, thereby offering new opportunities for vessel-targeting therapies. Within the framework of the Childhood Cancer Data Initiative (CCDI), the integration of multi-omic datasets, imaging biomarkers, and therapeutic response profiles can provide critical insights into the molecular determinants of angiogenesis in childhood cancers. Leveraging these data-driven approaches has the potential to refine predictive biomarkers, guide patient stratification, and accelerate the development of effective vessel-targeted therapeutics tailored to pediatric oncology. Ultimately, the convergence of molecular biology, nanomedicine, and large-scale data sharing through CCDI represents a transformative pathway for advancing childhood cancer research and improving clinical outcomes.
    Keywords:
    Childhood cancer, angiogenesis, tumor vessel targeting, nanomedicine, CCDI, pediatric oncology. 
  abstract_title_: 'Transforming Childhood Cancer through Tumor Vessel-Targeting Therapy. '
  email_address_: priyarithikavella@gmail.com
  institution_: 'Malla Reddy University. '
  presenting_author_: 'Priya Rithika Vella '