Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #3

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data:
  list_of_additional_authors:
    - add_author_degrees: MPH
      affiliation: 'Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health'
      first_name: Caroline
      last_name: Pruitt
    - add_author_degrees: Phd
      affiliation: 'Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health'
      first_name: Jared
      last_name: Fisher
    - add_author_degrees: PhD
      affiliation: 'Slone Epidemiology Center, Boston University'
      first_name: Julie
      last_name: Palmer
    - add_author_degrees: PhD
      affiliation: 'Slone Epidemiology Center, Boston University'
      first_name: Kimberly
      last_name: Bertrand
    - add_author_degrees: 'PhD, MS'
      affiliation: 'Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health'
      first_name: Rena
      last_name: Jones
  degree_s_: 'PhD, MS'
  email: jmadri1@uis.edu
  first_name: Jessica
  last_name: Madrigal
  middle_initial: ''
  organization: 'University of Illinois'
  summary: |-
    Background: Industrial facilities emit known mammary carcinogens and endocrine disrupting chemicals to air, including chemicals associated with breast cancer in epidemiological studies of post-menopausal and non-Hispanic White women. We investigated these relationships in a prospective cohort of Black women. 

    Methods: We used the US Environmental Protection Agency’s Toxics Release Inventory to estimate historical airborne emissions (1987-1995) of 19 chemicals and metals with prior evidence of mammary carcinogenicity and/or estrogenicity among 49,256 premenopausal and postmenopausal women enrolled (1995) in the Black Women’s Health Study. A total of 3,585 breast cancers were diagnosed through 2021. We constructed inverse distance- and wind-weighted average emissions metrics for each chemical within 2, 5 and 10km of the enrollment address. We estimated multivariable adjusted (age, region, smoking, parity, body mass index) HRs and 95% CIs for exposure tertiles (T) or quartiles (Q) in association with breast cancer risk. 

    Results: For cobalt exposure within 2km of the home, the HR for the highest tertile of exposure vs. non-exposed was 1.38, CI=0.97-1.98; p-trend=0.06. The association was attenuated for exposure within 5km (HRT3 vs. non-exposed=1.13, CI=0.96-1.32; p-trend=0.13) and 10km (HRT3 vs. non-exposed=1.06, CI=0.95-1.18; p-trend=0.34). For lead exposure within 2km of the home, the HR for the highest quartile versus non-exposed was 1.21, CI=0.81-1.78; p-trend=0.32; the HRs were similarly weakened at 5km and 10km. Associations with other chemicals and metals were null or lacked clear patterns. 

    Conclusion: Suggestive findings of increased breast cancer risk in association with relatively high air emissions of cobalt and lead from industrial sources near the home warrant further study.
  title: 'Associate Professor'
  ttile: 'Chemical and metal emissions from industrial sources and breast cancer risk in the Black Women’s Health Study '