Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #3

Presenter Information
---------------------
First Name: Jessica
Middle Initial: {Empty}
Last Name: Madrigal
Degree(s): PhD, MS
Position/Title/Career Status: Associate Professor
Organization: University of Illinois
Email: jmadri1@uis.edu

Additional Authors
------------------
List of Additional Authors:
- First Name: Caroline
  Last Name: Pruitt
  Degrees: MPH
  Affiliation: Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- First Name: Jared
  Last Name: Fisher
  Degrees: Phd
  Affiliation: Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- First Name: Julie
  Last Name: Palmer
  Degrees: PhD
  Affiliation: Slone Epidemiology Center, Boston University
- First Name: Kimberly
  Last Name: Bertrand
  Degrees: PhD
  Affiliation: Slone Epidemiology Center, Boston University
- First Name: Rena
  Last Name: Jones
  Degrees: PhD, MS
  Affiliation: Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health


Abstract Information
--------------------
Abstract Title: Chemical and metal emissions from industrial sources and breast cancer risk in the Black Women’s Health Study 
Abstract:
Background: Industrial facilities emit known mammary carcinogens and endocrine disrupting chemicals to air, including chemicals associated with breast cancer in epidemiological studies of post-menopausal and non-Hispanic White women. We investigated these relationships in a prospective cohort of Black women. 

Methods: We used the US Environmental Protection Agency’s Toxics Release Inventory to estimate historical airborne emissions (1987-1995) of 19 chemicals and metals with prior evidence of mammary carcinogenicity and/or estrogenicity among 49,256 premenopausal and postmenopausal women enrolled (1995) in the Black Women’s Health Study. A total of 3,585 breast cancers were diagnosed through 2021. We constructed inverse distance- and wind-weighted average emissions metrics for each chemical within 2, 5 and 10km of the enrollment address. We estimated multivariable adjusted (age, region, smoking, parity, body mass index) HRs and 95% CIs for exposure tertiles (T) or quartiles (Q) in association with breast cancer risk. 

Results: For cobalt exposure within 2km of the home, the HR for the highest tertile of exposure vs. non-exposed was 1.38, CI=0.97-1.98; p-trend=0.06. The association was attenuated for exposure within 5km (HRT3 vs. non-exposed=1.13, CI=0.96-1.32; p-trend=0.13) and 10km (HRT3 vs. non-exposed=1.06, CI=0.95-1.18; p-trend=0.34). For lead exposure within 2km of the home, the HR for the highest quartile versus non-exposed was 1.21, CI=0.81-1.78; p-trend=0.32; the HRs were similarly weakened at 5km and 10km. Associations with other chemicals and metals were null or lacked clear patterns. 

Conclusion: Suggestive findings of increased breast cancer risk in association with relatively high air emissions of cobalt and lead from industrial sources near the home warrant further study.