Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #14

serial: '14'
sid: '154343'
uuid: 423423e7-449d-4e2b-b61c-84ebcae30132
uri: '/egrp/cohortconsortium/abstracts?cid=eb_govdel'
created: '1757553904'
completed: '1757554931'
changed: '1757554931'
in_draft: '0'
current_page: ''
remote_addr: 10.208.28.116
uid: '0'
langcode: en
webform_id: cohort_2024_abstracts_submission
entity_type: node
entity_id: '1467'
locked: '0'
sticky: '0'
notes: ''
metatag: meta
data:
  additional_authors:
    - add_author_degree: Ph.D
      add_author_first_name: Feng
      add_author_last_name: Wu
      add_author_middle: ''
      add_author_organization: 'NYU Grossman School of Medicine'
    - add_author_degree: Ph.D
      add_author_first_name: 'Soyoung '
      add_author_last_name: Kwak
      add_author_middle: ''
      add_author_organization: 'NYU Grossman School of Medicine'
    - add_author_degree: Ph.D
      add_author_first_name: 'Chan '
      add_author_last_name: Wang
      add_author_middle: ''
      add_author_organization: 'NYU Grossman School of Medicine'
    - add_author_degree: Ph.D
      add_author_first_name: 'Mykhaylo '
      add_author_last_name: Usyk
      add_author_middle: ''
      add_author_organization: 'Albert Einstein College of Medicine'
    - add_author_degree: Ph.D
      add_author_first_name: 'Neal '
      add_author_last_name: Freedman
      add_author_middle: D.
      add_author_organization: 'National Cancer Institute'
    - add_author_degree: Ph.D
      add_author_first_name: Wen-Yi
      add_author_last_name: Huang
      add_author_middle: ''
      add_author_organization: 'National Cancer Institute'
    - add_author_degree: Ph.D
      add_author_first_name: 'Caroline '
      add_author_last_name: Um
      add_author_middle: Y.
      add_author_organization: 'American Cancer Society'
    - add_author_degree: M.D
      add_author_first_name: 'Tamas '
      add_author_last_name: Gonda
      add_author_middle: A.
      add_author_organization: 'NYU Grossman School of Medicine'
    - add_author_degree: M.D
      add_author_first_name: 'Paul '
      add_author_last_name: Oberstein
      add_author_middle: E.
      add_author_organization: 'NYU Laura and Isaac Perlmutter Cancer Center'
    - add_author_degree: Ph.D
      add_author_first_name: 'Huilin '
      add_author_last_name: Li
      add_author_middle: ''
      add_author_organization: 'NYU Grossman School of Medicine'
    - add_author_degree: 'DDS, Ph.D'
      add_author_first_name: 'Richard '
      add_author_last_name: Hayes
      add_author_middle: B.
      add_author_organization: 'NYU Grossman School of Medicine'
    - add_author_degree: Ph.D
      add_author_first_name: 'Jiyoung '
      add_author_last_name: Ahn
      add_author_middle: ''
      add_author_organization: 'NYU Grossman School of Medicine'
  degree_s_: Ph.D
  email: yixuan.meng@nyulangone.org
  first_name: Yixuan
  last_name: Meng
  organization: 'NYU Grossman School of Medicine'
  poster_title: 'Oral Bacterial and Fungal Microbiome and Subsequent Risk for Pancreatic Cancer '
  short_biography_: |-
    Importance: The oral microbiota may be involved in the development of pancreatic cancer, yet current evidence is largely limited to bacterial 16S amplicon sequencing and small retrospective case‒control studies.
    Objective: To test whether the oral bacterial and fungal microbiome is associated with the subsequent development of pancreatic cancer. 
    Design: This cohort study used data from 2 epidemiological cohorts: the American Cancer Society Cancer Prevention Study-II Nutrition Cohort and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
    Exposures: The oral bacterial and fungal microbiome were characterized via whole-genome shotgun sequencing and internal transcribed spacer (ITS) sequencing, respectively. The association of the microbiome-wide bacterial and fungal taxa with pancreatic cancer was assessed by Analysis of Compositions of Microbiomes with Bias Correction 2 (ANCOM-BC2).
    Results: Three oral bacterial periodontal pathogens—Porphyromonas gingivalis, Eubacterium nodatum, and Parvimonas micra—were associated with increased risk for pancreatic cancer. A bacteriome-wide scan revealed 8 oral bacteria associated with decreased and 13 oral bacteria associated with increased risk of pancreatic cancer (false discovery rate-adjusted q-values<0.05). Of the fungi, genus Candida was associated with increased risk of pancreatic cancer. The microbial risk score (MRS), based on 27 oral species, was associated with an increase in pancreatic cancer risk (multivariate odds ratio per 1-SD increase in MRS, 3.44, 95% CI, 2.63–4.51).
    Conclusions: In this cohort study, oral bacteria and fungi were significant risk factors for pancreatic cancer development. Oral microbiota hold promises as biomarkers to identify individuals at high risk of pancreatic cancer, potentially contributing to personalized prevention.
  title: ''