Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #14

Lightning Talks Abstract
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Presenter's First Name: : Yixuan
Presenter's Last Name:: Meng
Title (eg: professor, assistant professor, chair, etc):: {Empty}
Degree(s): Ph.D
Contact Email:: yixuan.meng@nyulangone.org
Organization:: NYU Grossman School of Medicine
Project Title:: Oral Bacterial and Fungal Microbiome and Subsequent Risk for Pancreatic Cancer 
Additional Authors:
1. First Name: Feng
   Last Name: Wu
   Degree(s): Ph.D
   Organization: NYU Grossman School of Medicine
2. First Name: Soyoung 
   Last Name: Kwak
   Degree(s): Ph.D
   Organization: NYU Grossman School of Medicine
3. First Name: Chan 
   Last Name: Wang
   Degree(s): Ph.D
   Organization: NYU Grossman School of Medicine
4. First Name: Mykhaylo 
   Last Name: Usyk
   Degree(s): Ph.D
   Organization: Albert Einstein College of Medicine
5. First Name: Neal 
   Middle Initial: D.
   Last Name: Freedman
   Degree(s): Ph.D
   Organization: National Cancer Institute
6. First Name: Wen-Yi
   Last Name: Huang
   Degree(s): Ph.D
   Organization: National Cancer Institute
7. First Name: Caroline 
   Middle Initial: Y.
   Last Name: Um
   Degree(s): Ph.D
   Organization: American Cancer Society
8. First Name: Tamas 
   Middle Initial: A.
   Last Name: Gonda
   Degree(s): M.D
   Organization: NYU Grossman School of Medicine
9. First Name: Paul 
   Middle Initial: E.
   Last Name: Oberstein
   Degree(s): M.D
   Organization: NYU Laura and Isaac Perlmutter Cancer Center
10. First Name: Huilin 
    Last Name: Li
    Degree(s): Ph.D
    Organization: NYU Grossman School of Medicine
11. First Name: Richard 
    Middle Initial: B.
    Last Name: Hayes
    Degree(s): DDS, Ph.D
    Organization: NYU Grossman School of Medicine
12. First Name: Jiyoung 
    Last Name: Ahn
    Degree(s): Ph.D
    Organization: NYU Grossman School of Medicine

Abstract::
Importance: The oral microbiota may be involved in the development of pancreatic cancer, yet current evidence is largely limited to bacterial 16S amplicon sequencing and small retrospective case‒control studies.
Objective: To test whether the oral bacterial and fungal microbiome is associated with the subsequent development of pancreatic cancer. 
Design: This cohort study used data from 2 epidemiological cohorts: the American Cancer Society Cancer Prevention Study-II Nutrition Cohort and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Exposures: The oral bacterial and fungal microbiome were characterized via whole-genome shotgun sequencing and internal transcribed spacer (ITS) sequencing, respectively. The association of the microbiome-wide bacterial and fungal taxa with pancreatic cancer was assessed by Analysis of Compositions of Microbiomes with Bias Correction 2 (ANCOM-BC2).
Results: Three oral bacterial periodontal pathogens—Porphyromonas gingivalis, Eubacterium nodatum, and Parvimonas micra—were associated with increased risk for pancreatic cancer. A bacteriome-wide scan revealed 8 oral bacteria associated with decreased and 13 oral bacteria associated with increased risk of pancreatic cancer (false discovery rate-adjusted q-values<0.05). Of the fungi, genus Candida was associated with increased risk of pancreatic cancer. The microbial risk score (MRS), based on 27 oral species, was associated with an increase in pancreatic cancer risk (multivariate odds ratio per 1-SD increase in MRS, 3.44, 95% CI, 2.63–4.51).
Conclusions: In this cohort study, oral bacteria and fungi were significant risk factors for pancreatic cancer development. Oral microbiota hold promises as biomarkers to identify individuals at high risk of pancreatic cancer, potentially contributing to personalized prevention.