Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #17

serial: '17'
sid: '127596'
uuid: 636ee063-e34d-46da-a23d-0462a2acc4a5
uri: /egrp/cohortconsortium/abstracts
created: '1726283096'
completed: '1726283837'
changed: '1726283837'
in_draft: '0'
current_page: ''
remote_addr: 10.208.24.118
uid: '0'
langcode: en
webform_id: cohort_2024_abstracts_submission
entity_type: node
entity_id: '1467'
locked: '0'
sticky: '0'
notes: ''
data:
  additional_authors:
    - add_author_degree: MSc
      add_author_first_name: Jani
      add_author_last_name: Koponen
      add_author_middle: ''
      add_author_organization: 'Finnish Institute of Health and Welfare'
    - add_author_degree: 'PhD, MS'
      add_author_first_name: Joshua
      add_author_last_name: Sampson
      add_author_middle: 'N'
      add_author_organization: NCI/DCEG
    - add_author_degree: 'PhD, MSPH'
      add_author_first_name: Alexander
      add_author_last_name: Keil
      add_author_middle: P
      add_author_organization: NCI/DCEG
    - add_author_degree: PhD
      add_author_first_name: Mary
      add_author_last_name: Ward
      add_author_middle: H
      add_author_organization: NCI/DCEG
    - add_author_degree: 'PhD, MPH'
      add_author_first_name: Jonathan
      add_author_last_name: Hofmann
      add_author_middle: 'N'
      add_author_organization: NCI/DCEG
    - add_author_degree: 'PhD, MSPH'
      add_author_first_name: Wen-Yi
      add_author_last_name: Huang
      add_author_middle: ''
      add_author_organization: NCI/DCEG
    - add_author_degree: 'ScD, ScM'
      add_author_first_name: Debra
      add_author_last_name: Silverman
      add_author_middle: T
      add_author_organization: NCI/DCEG
    - add_author_degree: PhD
      add_author_first_name: Panu
      add_author_last_name: Rantakokko
      add_author_middle: ''
      add_author_organization: 'Finnish Institute of Health and Welfare'
    - add_author_degree: PhD
      add_author_first_name: Mark
      add_author_last_name: Purdue
      add_author_middle: P
      add_author_organization: NCI/DCEG
  degree_s_: 'ScD, MS'
  email: jongeun.rhee@nih.gov
  first_name: Jongeun
  last_name: Rhee
  organization: NCI/DCEG
  poster_title: 'Serum concentrations of per- and polyfluorinated substances and risk of non-Hodgkin lymphoma '
  short_biography_: 'Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants detectable in the serum of most U.S. adults. Some studies of highly-exposed individuals have suggested positive associations between PFAS and non-Hodgkin lymphoma (NHL). To investigate whether associations exist at lower exposure levels, we conducted a nested case-control study investigating serum PFAS and NHL within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. We measured pre-diagnostic serum concentrations of five PFAS among 706 cases and 706 matched controls. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for PFAS in relation to NHL, overall and for histologic subtypes [diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), and marginal zone lymphoma (MZL)] using conditional logistic regression. We found no evidence of a positive association with NHL for any of the five PFAS. In analyses of histologic subtypes, perfluorohexane sulfonate (PFHxS) was significantly associated with DLBCL in a model adjusting for all other PFAS (OR for highest vs. lowest quintile =2.19, 95% CI=1.21, 3.95; Ptrend=0.02), but not without mutual adjustment (OR=1.37, 95% CI=0.82, 2.29; Ptrend=0.26). We also observed an inverse association between perfluorononanoate and DLBCL (mutually-adjusted OR=0.83, 95% CI=0.69, 0.99 per doubling in concentration), although the association was only apparent among those with blood drawn in 1997 or later (Pinteraction=0.0003). In conclusion, our findings from a prospective cohort study with PFAS concentrations comparable to the general population do not support an association with increased risk of NHL overall. The suggestive positive association between PFHxS and DLBCL warrants further investigation. '
  title: 'Research Fellow'