Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #17

Submission information
Submission Number: 17
Submission ID: 127596
Submission UUID: 636ee063-e34d-46da-a23d-0462a2acc4a5

Created: Fri, 09/13/2024 - 23:04
Completed: Fri, 09/13/2024 - 23:17
Changed: Fri, 09/13/2024 - 23:17

Remote IP address: 10.208.24.118
Submitted by: Anonymous
Language: English

Is draft: No
Presenter's First Name: Jongeun
Presenter's Last Name: Rhee
Title (eg: professor, assistant professor, chair, etc): Research Fellow
Degree(s) ScD, MS
Contact Email: jongeun.rhee@nih.gov
Organization: NCI/DCEG
Project Title: Serum concentrations of per- and polyfluorinated substances and risk of non-Hodgkin lymphoma
Additional Authors
  1. First Name: Jani
    Last Name: Koponen
    Degree(s): MSc
    Organization: Finnish Institute of Health and Welfare
  2. First Name: Joshua
    Middle Initial: N
    Last Name: Sampson
    Degree(s): PhD, MS
    Organization: NCI/DCEG
  3. First Name: Alexander
    Middle Initial: P
    Last Name: Keil
    Degree(s): PhD, MSPH
    Organization: NCI/DCEG
  4. First Name: Mary
    Middle Initial: H
    Last Name: Ward
    Degree(s): PhD
    Organization: NCI/DCEG
  5. First Name: Jonathan
    Middle Initial: N
    Last Name: Hofmann
    Degree(s): PhD, MPH
    Organization: NCI/DCEG
  6. First Name: Wen-Yi
    Last Name: Huang
    Degree(s): PhD, MSPH
    Organization: NCI/DCEG
  7. First Name: Debra
    Middle Initial: T
    Last Name: Silverman
    Degree(s): ScD, ScM
    Organization: NCI/DCEG
  8. First Name: Panu
    Last Name: Rantakokko
    Degree(s): PhD
    Organization: Finnish Institute of Health and Welfare
  9. First Name: Mark
    Middle Initial: P
    Last Name: Purdue
    Degree(s): PhD
    Organization: NCI/DCEG
Abstract: Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants detectable in the serum of most U.S. adults. Some studies of highly-exposed individuals have suggested positive associations between PFAS and non-Hodgkin lymphoma (NHL). To investigate whether associations exist at lower exposure levels, we conducted a nested case-control study investigating serum PFAS and NHL within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. We measured pre-diagnostic serum concentrations of five PFAS among 706 cases and 706 matched controls. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for PFAS in relation to NHL, overall and for histologic subtypes [diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), and marginal zone lymphoma (MZL)] using conditional logistic regression. We found no evidence of a positive association with NHL for any of the five PFAS. In analyses of histologic subtypes, perfluorohexane sulfonate (PFHxS) was significantly associated with DLBCL in a model adjusting for all other PFAS (OR for highest vs. lowest quintile =2.19, 95% CI=1.21, 3.95; Ptrend=0.02), but not without mutual adjustment (OR=1.37, 95% CI=0.82, 2.29; Ptrend=0.26). We also observed an inverse association between perfluorononanoate and DLBCL (mutually-adjusted OR=0.83, 95% CI=0.69, 0.99 per doubling in concentration), although the association was only apparent among those with blood drawn in 1997 or later (Pinteraction=0.0003). In conclusion, our findings from a prospective cohort study with PFAS concentrations comparable to the general population do not support an association with increased risk of NHL overall. The suggestive positive association between PFHxS and DLBCL warrants further investigation.