Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #7

Lightning Talks Abstract
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Presenter's First Name: : Armen









Presenter's Last Name:: Byrd









Title (eg: professor, assistant professor, chair, etc):: Assistant Member









Degree(s): MPH, PhD









Contact Email:: doratha.byrd@moffitt.org









Organization:: Moffitt Cancer Center









Project Title:: Characterizing drivers of prognosis and quality of life among Black colorectal cancer survivors: a pooled approach









Additional Authors:
1. First Name: Shaneda 
   Last Name: Warren Andersen
   Organization: University of Wisconsin-Madison










Abstract::
Colorectal cancer (CRC) is the second overall leading cause of cancer death in the United States. CRC poses a disproportionate burden among Black individuals, who experience substantially higher recurrence and mortality rates. In the ColoCare cohort, Black CRC survivors had higher risks for mortality, poorer disease-free survival, and differences in potentially clinically actional tumor mutational status. Approaches to improve survivorship outcomes among Black CRC survivors are urgently needed; however, most existing prospective survivorship cohort studies have limited ability to adequately assess potentially actionable drivers of cancer outcomes among this population due to small sample sizes (particularly among ethnic subgroups). To address this gap, we propose to create a forum for collaboration across survivorship cohorts to facilitate deep analyses of the multidimensional aspects of tumor biology and outcomes among Black CRC survivors.  To do this, we propose to pool data from Black CRC survivors in existing prospective cohorts to assess the multi-level drivers of survivorship outcomes including 1) tumor molecular profiles; 2) the local and peripheral immune system; 3) intervenable lifestyle exposures; 4) the gastrointestinal microbiome; and 5) social drivers of health. We will leverage the resources of multiple cohorts–including the ColoCare study, the Cancer Genome Atlas, the Southern Community Cohort, the African Caribbean Consortium, and the Detroit Research on Cancer Survivors study, and the Women’s Health Initiative-Life and Longevity After Cancer study– with biospecimens and data collected at diagnosis and afterward. Integration of these cohorts will allow for powerful analyses of predictors of outcomes among Black CRC survivors.