Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #6

serial: '6'
sid: '127263'
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uri: /egrp/cohortconsortium/abstracts
created: '1726062174'
completed: '1726063841'
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langcode: en
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data:
  additional_authors:
    - add_author_degree: PhD
      add_author_first_name: Jessica
      add_author_last_name: Petrick
      add_author_middle: L
      add_author_organization: 'Boston University'
    - add_author_degree: PhD
      add_author_first_name: Barry
      add_author_last_name: Graubard
      add_author_middle: I
      add_author_organization: 'National Cancer Institute'
    - add_author_degree: ''
      add_author_first_name: ''
      add_author_last_name: 'Liver Cancer Pooling Project Collaborators'
      add_author_middle: ''
      add_author_organization: ''
    - add_author_degree: PhD
      add_author_first_name: Dinesh
      add_author_last_name: Barupal
      add_author_middle: ''
      add_author_organization: 'Icahn School of Medicine at Mount Sinai'
    - add_author_degree: PhD
      add_author_first_name: Katherine
      add_author_last_name: McGlynn
      add_author_middle: A
      add_author_organization: 'National Cancer Institute'
  degree_s_: 'MSc., DPhil.'
  email: cody.watling@gmail.com
  first_name: Cody
  last_name: Watling
  organization: 'National Cancer Institute'
  poster_title: 'Circulating per- and polyfluoroalkyl substances and risk of liver cancer: a nested case- control analysis of individual participant data from 12 prospective cohorts'
  short_biography_: |-
    Background: Per- and polyfluoroalkyl substances (PFAS) have been associated with numerous deleterious health outcomes including liver damage. However, whether exposure to PFAS is related to liver cancer risk remains unclear.

    Methods: We conducted a nested case-control study among 12 prospective cohort studies located in the United States. Pre-diagnostic PFAS, namely perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS), were measured among 853 liver cancer cases and 853 matched control participants. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable-adjusted conditional logistic regression for liver cancer risk by study-specific quartiles of concentrations and per 90th vs. 10th percentile incremental increase.

    Results:
    In the main multivariable-adjusted model, circulating PFOS, PFOA, and PFHxS concentrations were not associated with liver cancer risk (OR per 90th vs. 10th percentile increase:1.00, 95% CI: 0.79-1.28; 0.92, 0.73-1.15; and 0.95, 0.75-1.21, respectively). However, when analyses were stratified by sex, PFOA concentrations were positively associated with liver cancer risk in males (OR per 90th vs. 10th percentile increase:1.62 95% CI:1.07-2.45), whereas an inverse association was observed amongst females (OR per 90th vs. 10th percentile increase:0.68, 0.50-0.92). Analyses separating liver cancer subtypes, hepatocellular carcinoma (HCC) and intrahepatic
    cholangiocarcinoma, showed no evidence of heterogeneity although associations were stronger but not significant for HCC. No evidence of heterogeneity was observed by time to diagnosis, body mass index, alcohol intake, ethnicity, or diabetes status.

    Conclusions: In the largest study to date, none of the measured circulating PFAS were associated with liver cancer risk; however, PFOA associations appeared to differ by sex.
  title: 'Postdoctoral Fellow'