Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #6

Submission information
Submission Number: 6
Submission ID: 127263
Submission UUID: 2be8977f-a34e-4680-b2ee-32a1ec4e57a2

Created: Wed, 09/11/2024 - 09:42
Completed: Wed, 09/11/2024 - 10:10
Changed: Wed, 09/11/2024 - 10:10

Remote IP address: 10.208.28.69
Submitted by: Anonymous
Language: English

Is draft: No
Presenter's First Name: Cody
Presenter's Last Name: Watling
Title (eg: professor, assistant professor, chair, etc): Postdoctoral Fellow
Degree(s) MSc., DPhil.
Contact Email: cody.watling@gmail.com
Organization: National Cancer Institute
Project Title: Circulating per- and polyfluoroalkyl substances and risk of liver cancer: a nested case- control analysis of individual participant data from 12 prospective cohorts
Additional Authors
  1. First Name: Jessica
    Middle Initial: L
    Last Name: Petrick
    Degree(s): PhD
    Organization: Boston University
  2. First Name: Barry
    Middle Initial: I
    Last Name: Graubard
    Degree(s): PhD
    Organization: National Cancer Institute
  3. Last Name: Liver Cancer Pooling Project Collaborators
  4. First Name: Dinesh
    Last Name: Barupal
    Degree(s): PhD
    Organization: Icahn School of Medicine at Mount Sinai
  5. First Name: Katherine
    Middle Initial: A
    Last Name: McGlynn
    Degree(s): PhD
    Organization: National Cancer Institute
Abstract: Background: Per- and polyfluoroalkyl substances (PFAS) have been associated with numerous deleterious health outcomes including liver damage. However, whether exposure to PFAS is related to liver cancer risk remains unclear.

Methods: We conducted a nested case-control study among 12 prospective cohort studies located in the United States. Pre-diagnostic PFAS, namely perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS), were measured among 853 liver cancer cases and 853 matched control participants. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable-adjusted conditional logistic regression for liver cancer risk by study-specific quartiles of concentrations and per 90th vs. 10th percentile incremental increase.

Results:
In the main multivariable-adjusted model, circulating PFOS, PFOA, and PFHxS concentrations were not associated with liver cancer risk (OR per 90th vs. 10th percentile increase:1.00, 95% CI: 0.79-1.28; 0.92, 0.73-1.15; and 0.95, 0.75-1.21, respectively). However, when analyses were stratified by sex, PFOA concentrations were positively associated with liver cancer risk in males (OR per 90th vs. 10th percentile increase:1.62 95% CI:1.07-2.45), whereas an inverse association was observed amongst females (OR per 90th vs. 10th percentile increase:0.68, 0.50-0.92). Analyses separating liver cancer subtypes, hepatocellular carcinoma (HCC) and intrahepatic
cholangiocarcinoma, showed no evidence of heterogeneity although associations were stronger but not significant for HCC. No evidence of heterogeneity was observed by time to diagnosis, body mass index, alcohol intake, ethnicity, or diabetes status.

Conclusions: In the largest study to date, none of the measured circulating PFAS were associated with liver cancer risk; however, PFOA associations appeared to differ by sex.