NCI Data Jamboree (Project Abstract Submission): Submission #29

serial: '29'
sid: '188876'
uuid: 7890ff20-749a-449c-9f04-5a1f558d44c4
uri: /nci/datajamboree/abstractsubmission
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data:
  list_of_additional_authors: {  }
  category: 'Enhancing data interoperability (e.g., data harmonization, data federation)'
  degree_s_: 'BS, MS'
  email: chetan.kottidi@lexisnexisrisk.com
  first_name: Chetan
  keywords_abstracts: 'SEER SDOH Financial Toxicity Real World Data Cancer Research'
  last_name: Kottidi
  middle_initial: R
  organization: 'LexisNexis Risk Solutions'
  organization_address:
    address: ''
    address_2: ''
    city: 'McLean, VA'
    country: ''
    postal_code: ''
    state_province: ''
  summary: |
    **Title:** **Enriching SEER Registries with Residential History, Social Determinants of Health, and Financial Toxicity Real-World Data to Advance Equitable Cancer Research**

    **Abstract**

    The National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) Program is the nation’s premier population-based cancer registry, providing critical data to support cancer surveillance, epidemiology, and outcomes research. While SEER captures comprehensive clinical and demographic information, integrating complementary real-world data (RWD) can provide a more complete understanding of the social, geographic, and financial factors that influence cancer outcomes.

    This project proposes enriching SEER registries with longitudinal residential history, Social Determinants of Health (SDOH), and financial toxicity RWD to create a research-ready dataset that strengthens analyses across the cancer care continuum. Residential history enables investigators to reconstruct patient mobility, evaluate environmental exposures, assess healthcare accessibility, and examine continuity of care over time. SDOH measures including housing stability, transportation access, neighborhood deprivation, food access, educational attainment,and broadband availability provide valuable context for understanding disparities in cancer prevention, diagnosis, treatment, and survivorship.

    The project also incorporates financial toxicity RWD to measure the economic burden experienced by cancer patients during and after treatment. Indicators such as medical debt, bankruptcy, collections activity, liens, and other validated measures of financial distress enable researchers to evaluate how financial hardship influences treatment adherence, healthcare utilization, clinical trial participation, survivorship, and survival outcomes.

    Using privacy-preserving identity resolution and record linkage, these external data assets can be securely integrated with SEER while protecting patient privacy. The enriched dataset will enable investigators to identify populations at risk for poor outcomes, develop predictive models, evaluate interventions that reduce disparities, and generate robust real-world evidence. By combining clinical, social, geographic, and financial context, this project advances NCI priorities in health equity, precision public health, and patient-centered cancer research while enhancing the scientific value of SEER for researchers, clinicians, and policymakers.
  title: ''
  ttile: 'Enriching SEER Registries with Residential History, Social Determinants of Health, and Financial Toxicity Real-World Data to Advance Equitable Cancer Research'