NCI Data Jamboree (Project Abstract Submission): Submission #23

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  category: 'Employing statistical, computational, and informatics tools, algorithms, and methods to integrate or analyze data'
  degree_s_: Ph.D
  email: k.raman@northeastern.edu
  first_name: Karthikeyan
  keywords_abstracts: 'Cancer Immunology, Transcriptomics, Multi-omics, Immunotherapy, Data Integration. '
  last_name: Raman
  middle_initial: ''
  organization: 'Northeastern University'
  organization_address:
    address: ''
    address_2: ''
    city: Boston
    country: ''
    postal_code: ''
    state_province: ''
  summary: |-
    I am a Senior Research Associate in the Konry Laboratory at Northeastern University with a background in cancer immunology, epigenomics, and functional genomics. My current research integrates functional immune-cell assays, transcriptomic profiling, and multi-omics approaches to investigate the molecular mechanisms governing natural killer (NK) cell and T-cell responses in cancer immunotherapy.
    My experience spans experimental genomics, epigenomics, and chromatin biology, including next-generation sequencing library preparation, bulk RNA-seq analysis, whole-genome sequencing, gene-expression and pathway analysis, chromatin profiling using NEED-seq, NicE-seq, CUT&RUN, and ChIP-seq, DNA methylation profiling, chromatin-state analysis, and biological interpretation of multi-omic datasets. I also have experience with molecular profiling of cancer tissues, including FFPE and laser-capture microdissected specimens from multiple cancer types, as well as mammalian cell culture, flow cytometry, fluorescence and confocal microscopy, molecular biology, and immune-cell functional and cytotoxicity assays.
    I am interested in joining interdisciplinary projects that use statistical, computational, and informatics approaches to analyze and integrate large-scale cancer datasets, particularly transcriptomic, epigenomic, single-cell, spatial, imaging, and proteomic data. The NCI Data Jamboree provides an opportunity to contribute my expertise in experimental cancer biology, epigenomics, and functional genomics while strengthening my skills in public cancer data resources, multimodal data integration, reproducible computational workflows, and cloud-based analysis.
    Through this experience, I hope to strengthen my ability to translate complex cancer datasets into biologically meaningful insights relevant to tumor–immune interactions and immunotherapy, expand my computational expertise, and establish productive interdisciplinary collaborations for future translational cancer research.
  title: 'Postdoctoral Research Associate'
  ttile: 'Bridging Experimental Cancer Immunology, Epigenomics, and Multi-omics Data Analysis'