Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #61

Abstract Submission for Poster Presentation
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Abstract Title:: Progress-to-date toward building a multicenter study comparing second cancer risks after radiotherapy: the Pediatric Proton and Photon Therapy Comparison Cohort
Abstract::
Proton radiotherapy has emerged as the preferred radiotherapy modality for some cancers, especially in children. Proton radiotherapy is expected to reduce the risk of subsequent cancer and other adverse long-term health effects compared to photon radiotherapy because the physical properties of protons allow for lower radiation exposure to surrounding normal tissues. However, the magnitude of the purported reduction in risk remains uncertain, and no randomized clinical trials have compared the two radiotherapy types in children, who are more susceptible to the late effects of radiation compared to adults. Observational studies, while generally reassuring, have had important methodological limitations. CCDI funding enabled establishment of the NCI Pediatric Proton and Photon Therapy Comparison Cohort, a large-scale multicenter study with the primary aim to compare the risk of subsequent cancers in pediatric cancer patients treated with proton versus photon radiotherapy. Patient and treatment data, including electronic radiotherapy records, are being collected for eligible patients treated 2006-2025 at 17 participating centers. Long-term follow-up for incident second cancers will be conducted via linkage with state cancer registries. State-of-the-art radiation dose reconstruction methods developed for application in this cohort will allow for assessment of radiation dose-response and dose volume effects. Our poster will discuss the status of ongoing clinical and radiotherapy data collection and describe the current study population by demographic and treatment factors. Research from this cohort is expected to inform clinical practice for pediatric cancer patients by providing the first large-scale systematic comparison of subsequent cancer risk after proton compared to photon therapy.  

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Authors::
1. First Name: Todd 
   Middle Initial: M
   Last Name: Gibson
   Degree(s): PhD
   Organization: National Cancer Institute
2. First Name: Sara
   Middle Initial: L
   Last Name: Dennehy
   Degree(s): MS
   Organization: Massachusetts General Hospital
3. First Name: Benjamin 
   Middle Initial: VM
   Last Name: Bajaj
   Degree(s): MPH
   Organization: Massachusetts General Hospital
4. First Name: Jungwook
   Last Name: Shin
   Degree(s): PhD
   Organization: National Cancer Institute
5. First Name: Matthew
   Middle Initial: M
   Last Name: Mille
   Degree(s): PhD
   Organization: National Cancer Institute
6. First Name: Keith
   Middle Initial: T
   Last Name: Griffin
   Degree(s): PhD
   Organization: National Cancer Institute
7. First Name: Sergio
   Last Name: Morato
   Degree(s): PhD
   Organization: National Cancer Institute
8. First Name: Isabelle
   Last Name: van der Velpen
   Degree(s): MD, PhD
   Organization: National Cancer Institute
9. First Name: Caroline
   Last Name: Esposito
   Degree(s): BA
   Organization: National Cancer Institute
10. First Name: Torunn
    Middle Initial: I
    Last Name: Yock
    Degree(s): MD
    Organization: Massachusetts General Hospital
11. First Name: Amy
    Last Name: Berrington
    Degree(s): DPhil
    Organization: Institute for Cancer Research
12. First Name: Choonsik
    Last Name: Lee
    Degree(s): PhD
    Organization: National Cancer Institute
13. First Name: Cari 
    Middle Initial: M
    Last Name: Kitahara
    Degree(s): PhD
    Organization: National Cancer Institute

Presenting Author:: Cari Kitahara
Institution:: National Cancer Institute
Email Address:: kitaharac@mail.nih.gov