Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #48

serial: '48'
sid: '150078'
uuid: 458369c0-9547-47ef-aec4-6bc56dbec5e2
uri: '/nci/ccdisymposium/abstract?cid=eb_govdel_ccdi_events'
created: '1756384339'
completed: '1756384514'
changed: '1756384514'
in_draft: '0'
current_page: ''
remote_addr: 10.208.28.90
uid: '0'
langcode: en
webform_id: ccdi_symposium_abstract
entity_type: node
entity_id: '2139'
locked: '0'
sticky: '0'
notes: ''
metatag: meta
data:
  authors_:
    - add_author_degree: 'MD, MSCE'
      add_author_first_name: Tamara
      add_author_last_name: Miller
      add_author_middle: P
      add_author_organization: "Emory University/Children's Healthcare of Atlanta"
    - add_author_degree: MS
      add_author_first_name: Gregory
      add_author_last_name: Joseph
      add_author_middle: ''
      add_author_organization: 'Emory University'
    - add_author_degree: MS
      add_author_first_name: Edward
      add_author_last_name: Krause
      add_author_middle: ''
      add_author_organization: "Children's Hospital of Philadelphia"
    - add_author_degree: ''
      add_author_first_name: 'Yun Gun'
      add_author_last_name: Jo
      add_author_middle: ''
      add_author_organization: "Children's Hospital of Philadelphia"
    - add_author_degree: ''
      add_author_first_name: Judy
      add_author_last_name: Lee
      add_author_middle: ''
      add_author_organization: "Children's Healthcare of Atlanta"
    - add_author_degree: MSIS
      add_author_first_name: Hannah
      add_author_last_name: Calkins
      add_author_middle: ''
      add_author_organization: "Children's Hospital of Philadelphia"
    - add_author_degree: PhD
      add_author_first_name: Adam
      add_author_last_name: Resnick
      add_author_middle: C
      add_author_organization: "Children's Hospital of Philadelphia"
    - add_author_degree: 'MD, PhD'
      add_author_first_name: Richard
      add_author_last_name: Aplenc
      add_author_middle: ''
      add_author_organization: "Children's Hospital of Philadelphia"
    - add_author_degree: PhD
      add_author_first_name: Allison
      add_author_last_name: Heath
      add_author_middle: ''
      add_author_organization: "Children's Hospital of Philadelphia"
  abstract: |-
    Background:
    The National Cancer Institute (NCI) Childhood Cancer Data Initiative (CCDI) has enabled the distribution of previously unshared data. A critical component to maximize the utility of these data is to have longitudinal clinical data, such as treatment data. Manual abstraction has typically been used to capture treatment data, but this process is time consuming and subject to human error. This study aimed to use automated extraction and processing of electronic health record (EHR) data using the ExtractEHR+ Toolkit to describe chemotherapy exposures for children enrolled in the Children’s Brain Tumor Network (CBTN) who have contributed data to the CCDI.

    Methods:
    Patients enrolled in CBTN at two hospitals were included. ExtractEHR extracted all medication orders and administrations, including outpatient prescriptions, heights, and weights. Medication order and administration data were merged and MedCleanEHR centrally cleaned these data to identify unique chemotherapy exposures and dose amounts. Height and weight data were used to calculate body surface area and merged with medication data. For prescriptions where a discrete dose field was not included, regular expressions were used to identify doses in free text fields. MedCleanEHR calculated cumulative chemotherapy doses each patient received. 

    Results:
    The cohort included 1628 patients. ExtractEHR successfully pulled 3,849,099 medication administrations and 839,736 medication orders. Once cleaned, there were 98,877 unique chemotherapy administrations and 8,781 chemotherapy prescriptions.

    Conclusions:
    The ExtractEHR+ Toolkit can efficiently ascertains chemotherapy exposures and dosing for patients in the CBTN cohort. These data will be transferred to the CCDI to enhance clinical data in the CCDI ecosystem.
  abstract_title_: 'Leveraging the ExtractEHR+ Toolkit to Enhance Medication Data in the Children’s Brain Tumor Network and Childhood Cancer Data Initiative'
  email_address_: tamara.miller@emory.edu
  institution_: "Emory University/Children's Healthcare of Atlanta"
  presenting_author_: 'Tamara P. Miller, MD, MSCE'