Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #15
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Submission Number: 15
Submission ID: 154433
Submission UUID: 625c0af0-5d85-4e23-b856-ac003c59653a
Submission URI: /egrp/cohortconsortium/abstracts
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Created: Thu, 09/11/2025 - 14:51
Completed: Thu, 09/11/2025 - 14:51
Changed: Thu, 09/11/2025 - 14:51
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Submitted by: Anonymous
Language: English
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Webform: Cohort 2025 (Abstracts Submission)
Lightning Talks Abstract
Tomotaka
Ugai
Division Chair
MD, PhD
National Cancer Center Research Institute (Japan), Harvard T.H. Chan School of Public Health, Brigham and Women's Hospital
Expanding initiatives for the integration of tumor analyses into prospective cohort studies
Background: Tumor biorepositories are essential in identifying tumor molecular subtypes and biomarkers. Inherent limitations of hospital-based tumor repositories include risk of selection bias due to convenience sampling, lack of (or recall bias) in long-term pre-diagnostic exposure information, etc. Tumor specimens collected from incident cancer cases nested within prospective cohorts can address some of these challenges for many reasons.
Methods/Results: Utilizing tumor biorepository resources that integrate tumor tissue samples from incident cancer cases with long-term pre- and post-diagnostic exposure data in the Nurses' Health Study I/II and the Health Professionals Follow-up Study, we have reported important links between exposures and tumor, mutational, microbial, immune, and other microenvironmental biomarkers. For example, we reported that long-term marine omega-3 polyunsaturated fatty acid intake was associated with decreased incidence of colorectal cancer (CRC) having abundant regulatory T cells and M1-like macrophages, and that long-term western-style diets were associated with increased incidence of pks+ Escherichia coli-rich CRC (early-onset CRC-associated feature).
Conclusions/Future Perspective: Considering that risk factors promote carcinogenesis through specific pathobiological mechanisms, integrating tumor cell/tissue profiling into epidemiologic research can provide pathogenetic clues and help us develop effective personalized prevention and treatment strategies. A major challenge is that existing tumor biobanks nested in prospective cohort studies are predominantly based on non-Hispanic white populations. We strive to address this challenge through collaboration with the GECCO Consortium and others. The Prostate Cancer Cohort Consortium is another successful example. We believe that expanding initiatives for the integration of tumor analyses into prospective studies will provide enormous opportunities.
Methods/Results: Utilizing tumor biorepository resources that integrate tumor tissue samples from incident cancer cases with long-term pre- and post-diagnostic exposure data in the Nurses' Health Study I/II and the Health Professionals Follow-up Study, we have reported important links between exposures and tumor, mutational, microbial, immune, and other microenvironmental biomarkers. For example, we reported that long-term marine omega-3 polyunsaturated fatty acid intake was associated with decreased incidence of colorectal cancer (CRC) having abundant regulatory T cells and M1-like macrophages, and that long-term western-style diets were associated with increased incidence of pks+ Escherichia coli-rich CRC (early-onset CRC-associated feature).
Conclusions/Future Perspective: Considering that risk factors promote carcinogenesis through specific pathobiological mechanisms, integrating tumor cell/tissue profiling into epidemiologic research can provide pathogenetic clues and help us develop effective personalized prevention and treatment strategies. A major challenge is that existing tumor biobanks nested in prospective cohort studies are predominantly based on non-Hispanic white populations. We strive to address this challenge through collaboration with the GECCO Consortium and others. The Prostate Cancer Cohort Consortium is another successful example. We believe that expanding initiatives for the integration of tumor analyses into prospective studies will provide enormous opportunities.