Animal Models for Cancer Interception and Precision Prevention Virtual Workshop (Agenda)

Agenda

Times listed are for Eastern Daylight Savings Time

Day 1: 9:00 AM - 5:30 PM
9:00-9:10 AM	Welcome Philip Castle, Ph.D., M.P.H, Director, DCP/NCI
9:10-9:15 AM	Altaf Mohammed, Ph.D., Workshop Co-Organizer, DCP/NCI
9:15-10:15 AM	Keynote Speaker: Charles Swanton, F.R.C.P., B.Sc., Ph.D. Role of environmental carcinogens in lung cancer initiation: insights from mouse models
SESSION I Status of the Current Cancer Prevention Research Animal Models Co-Chairs: Ming You, M.D., Ph.D. and Altaf Mohammed, Ph.D.
10:15-10:40 AM	Speaker 1: Chinthalapally (CV) Rao, Ph.D., University of Oklahoma Carcinogen Induced and Genetically Engineered Models (GEM) for Cancer Interception
10:40-11:05 AM	Speaker 2: Ming You, M.D., Ph.D., Houston Methodist Cancer Center Animal Models Testing Aerosolized Drug Delivery Approaches for Lung Cancer Chemoprevention
11:05-11:30 AM	Speaker 3: Melissa A. Pegues, Ph.D., U.S. FDA Nonclinical Considerations for Safety Evaluation of Drugs Intended to Reduce the Risk of Cancer
11:30-11:55 AM	Speaker 4: Michael T. Lewis, Ph.D., B.S., Baylor College of Medicine Toward Early Detection of Breast Cancer and Prevention of Disease Recurrence
11:55-12:30 PM	Lunch
12:30-12:55 PM	Speaker 5: Cory Abate-Shen, Ph.D., Columbia University Irving Medical Center Lessons learned from studying mouse models
12:55-1:20 PM	Speaker 6: Kevin Dodd, Ph.D., National Cancer Institute Statistical aspects of preclinical cancer prevention studies
1:20-2:00 PM	Panel Discussion with Session I Speakers
2:00-2:10 PM	Break
SESSION II Precision Animal Models for High-Risk Cancer Cohorts Co-Chairs: Shyam Sharan, Ph.D. and Bob Shoemaker, Ph.D.
2:10-2:35 PM	Speaker 1: Bob Shoemaker, Ph.D., National Cancer Institute Genetically Engineered Mouse Models of Lynch Syndrome
2:35-3:00 PM	Speaker 2: Shyam Sharan, Ph.D., NCI Center for Cancer Research BRCA mouse models for functional analysis of genetic variants and breast cancer prevention
3:00-3:25 PM	Speaker 3: James M. Amos-Landgraf, Ph.D., University of Missouri The interplay of host genetics and the gut microbiota on rodent models of familial colon cancer
3:25-3:35 PM	Break
3:35-4:00 PM	Speaker 4: Ludmila Szabova, Ph.D. Frederick National Laboratory for Cancer Research, NCI Ovarian cancer models for Cancer Prevention Research
4:00-4:25 PM	Speaker 5: Wen Xue, Ph.D., University of Massachusetts Medical School Precision cancer mouse model development through genome editing
4:25-4:50 PM	Speaker 6: Robert S. Chapkin, Ph.D., Texas A&M University Molecular insights into the mechanisms linking diet and microbial metabolites to colon cancer risk
4:50-5:25 PM	Panel Discussion with Session II Speakers
5:25-5:30 PM	Adjourn
Day 2: 9:00 AM - 5:30 PM
Session III Animal Models for Immunoprevention Co-Chairs: Phil Daschner, Ph.D. and Karolina Palucka, M.D., Ph.D.
9:00-9:25 AM	Speaker 1: Karolina Palucka, M.D., Ph.D., The Jackson Laboratory Humanized mice to study interactions between human cancer and immune system
9:25-9:50 AM	Speaker 2: Shannon Kenney, M.D., University of Wisconsin-Madison Humanized EBV mouse model
9:50-10:15 AM	Speaker 3: Silvia Guglietta, Ph.D., Medical University of South Carolina Loss of complement C3a receptor in a novel model of spontaneous colorectal tumorigenesis: potential for immunoprevention and therapeutic interventions
10:15-10:40 AM	Speaker 4: Guillermina (Gigi) Lozano, Ph.D., The University of Texas MD Anderson Cancer Center Modeling the p53 tumor suppressor pathway in mice
10:40-11:10 AM	Panel Discussion with Session III Speakers
11:10-11:20 PM	Break
Session IV Next Generation Models for Prevention Research Co-Chairs: Anirban Maitra, M.B.B.S. and Goli Samimi, Ph.D., M.P.H.
11:20-11:45 AM	Speaker 1: Anirban Maitra, M.B.B.S., The University of Texas MD Anderson Cancer Center Preclinical models of pancreatic cystic neoplasia
11:45-12:10 PM	Speaker 2: Fariba Behbod, Pharm.D., Ph.D., University of Kansas Medical Center Mouse-INtraDuctal: An in vivo model for studying breast cancer progression
12:10-12:35 PM	Speaker 3: Ji-Yong Julie Kim, Ph.D., Northwestern University Bioengineered Models of the Female Reproductive System: Understanding uterine diseases
12:35-1:10 PM	Lunch
1:10-1:35 PM	Speaker 4: Paul Macklin, Ph.D., Indiana University Bloomington Virtual experiments with multiscale agent-based models
1:35-2:00 PM	Speaker 5: David Tuveson, M.D., Ph.D., Cold Spring Harbor Laboratory Pancreatic Cancer Progression using Model Systems
Session V Large Animals for Translational Research Co-Chairs: Amy LeBlanc, V.M., D.A.C.V.I.M., and Amit Kumar, Ph.D.
2:00-2:25 PM	Speaker 1: Amy K. LeBlanc, D.V.M., D.A.C.V.I.M., Center for Cancer Research, NCI What Pet dogs can teach us about cancer
2:25-2:50 PM	Speaker 2: Paul Grippo, Ph.D., University of Illinois Cancer Center Large Animal Platform for Earlier Pancreatic Cancer Detection and Prevention
2:50-3:15 PM	Speaker 3: Stephen Albert Johnston, Calviri, Inc Dogs Are Not a Model: Status of a Canine Preventative Cancer Vaccine Trial (VACCS)
3:15-3:35 PM	Panel Discussion with Session V Speakers
3:35-3:45 PM	Break
Session VI Brainstorming and Future Directions Moderators: Altaf Mohammed, Amit Kumar and Phil Daschner
3:45-4:45 PM	Breakout Panel Discussion I Breakout Panel Discussion II
4:45-5:30 PM	Reconvene for final discussions
5:25-5:30 PM	Adjourn

Animal Models for Cancer Interception and Precision Prevention Virtual Workshop (Agenda)

Agenda

Day 1: 9:00 AM - 5:30 PM

Day 2: 9:00 AM - 5:30 PM