Animal Models for Cancer Interception and Precision Prevention Virtual Workshop (Agenda)


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Times listed are for Eastern Daylight Savings Time

Day 1: 9:00 AM - 5:30 PM

9:00-9:10 AM

Philip Castle, Ph.D., M.P.H, Director, DCP/NCI

9:10-9:15 AM

Altaf Mohammed, Ph.D., Workshop Co-Organizer, DCP/NCI

9:15-10:15 AM

Keynote Speaker: Charles Swanton, F.R.C.P., B.Sc., Ph.D.
Role of environmental carcinogens in lung cancer initiation: insights from mouse models

Status of the Current Cancer Prevention Research Animal Models
Co-Chairs: Ming You, M.D., Ph.D. and Altaf Mohammed, Ph.D.
10:15-10:40 AM

Speaker 1: Chinthalapally (CV) Rao, Ph.D., University of Oklahoma
Carcinogen Induced and Genetically Engineered Models (GEM) for Cancer Interception

10:40-11:05 AM

Speaker 2: Ming You, M.D., Ph.D., Houston Methodist Cancer Center
Animal Models Testing Aerosolized Drug Delivery Approaches for Lung Cancer Chemoprevention

11:05-11:30 AM

Speaker 3: Melissa A. Pegues, Ph.D., U.S. FDA
Nonclinical Considerations for Safety Evaluation of Drugs Intended to Reduce the Risk of Cancer

11:30-11:55 AM

Speaker 4: Michael T. Lewis, Ph.D., B.S., Baylor College of Medicine
Toward Early Detection of Breast Cancer and Prevention of Disease Recurrence

11:55-12:30 PM


12:30-12:55 PM

Speaker 5: Cory Abate-Shen, Ph.D., Columbia University Irving Medical Center
Lessons learned from studying mouse models

12:55-1:20 PM

Speaker 6: Kevin Dodd, Ph.D., National Cancer Institute
Statistical aspects of preclinical cancer prevention studies

1:20-2:00 PM

Panel Discussion with Session I Speakers

2:00-2:10 PM


Precision Animal Models for High-Risk Cancer Cohorts

Co-Chairs: Shyam Sharan, Ph.D. and Bob Shoemaker, Ph.D.
2:10-2:35 PM

Speaker 1: Bob Shoemaker, Ph.D., National Cancer Institute
Genetically Engineered Mouse Models of Lynch Syndrome

2:35-3:00 PM

Speaker 2: Shyam Sharan, Ph.D., NCI Center for Cancer Research
BRCA mouse models for functional analysis of genetic variants and breast cancer prevention

3:00-3:25 PM

Speaker 3: James M. Amos-Landgraf, Ph.D., University of Missouri
The interplay of host genetics and the gut microbiota on rodent models of familial colon cancer

3:25-3:35 PM


3:35-4:00 PM

Speaker 4: Ludmila Szabova, Ph.D. Frederick National Laboratory for Cancer Research, NCI
Ovarian cancer models for Cancer Prevention Research

4:00-4:25 PM

Speaker 5: Wen Xue, Ph.D., University of Massachusetts Medical School
Precision cancer mouse model development through genome editing

4:25-4:50 PM

Speaker 6: Robert S. Chapkin, Ph.D., Texas A&M University
Molecular insights into the mechanisms linking diet and microbial metabolites to colon cancer risk

4:50-5:25 PM

Panel Discussion with Session II Speakers

5:25-5:30 PM


Day 2: 9:00 AM - 5:30 PM

Session III
Animal Models for Immunoprevention

Co-Chairs: Phil Daschner, Ph.D. and Karolina Palucka, M.D., Ph.D.
9:00-9:25 AM

Speaker 1: Karolina Palucka, M.D., Ph.D., The Jackson Laboratory
Humanized mice to study interactions between human cancer and immune system

9:25-9:50 AM

Speaker 2: Shannon Kenney, M.D., University of Wisconsin-Madison
Humanized EBV mouse model

9:50-10:15 AM

Speaker 3: Silvia Guglietta, Ph.D., Medical University of South Carolina
Loss of complement C3a receptor in a novel model of spontaneous colorectal tumorigenesis: potential for immunoprevention and therapeutic interventions

10:15-10:40 AM

Speaker 4: Guillermina (Gigi) Lozano, Ph.D., The University of Texas MD Anderson Cancer Center
Modeling the p53 tumor suppressor pathway in mice

10:40-11:10 AM

Panel Discussion with Session III Speakers

11:10-11:20 PM


Session IV
Next Generation Models for Prevention Research

Co-Chairs: Anirban Maitra, M.B.B.S. and Goli Samimi, Ph.D., M.P.H.
11:20-11:45 AM

Speaker 1: Anirban Maitra, M.B.B.S., The University of Texas MD Anderson Cancer Center
Preclinical models of pancreatic cystic neoplasia

11:45-12:10 PM

Speaker 2: Fariba Behbod, Pharm.D., Ph.D., University of Kansas Medical Center
Mouse-INtraDuctal: An in vivo model for studying breast cancer progression

12:10-12:35 PM

Speaker 3: Ji-Yong Julie Kim, Ph.D., Northwestern University
Bioengineered Models of the Female Reproductive System: Understanding uterine diseases

12:35-1:10 PM


1:10-1:35 PM

Speaker 4: Paul Macklin, Ph.D., Indiana University Bloomington
Virtual experiments with multiscale agent-based models

1:35-2:00 PM

Speaker 5: David Tuveson, M.D., Ph.D., Cold Spring Harbor Laboratory
Pancreatic Cancer Progression using Model Systems

Session V
Large Animals for Translational Research

Co-Chairs: Amy LeBlanc, V.M., D.A.C.V.I.M., and Amit Kumar, Ph.D.
2:00-2:25 PM

Speaker 1: Amy K. LeBlanc, D.V.M., D.A.C.V.I.M., Center for Cancer Research, NCI
What Pet dogs can teach us about cancer

2:25-2:50 PM

Speaker 2: Paul Grippo, Ph.D., University of Illinois Cancer Center
Large Animal Platform for Earlier Pancreatic Cancer Detection and Prevention

2:50-3:15 PM

Speaker 3: Stephen Albert Johnston, Calviri, Inc
Dogs Are Not a Model: Status of a Canine Preventative Cancer Vaccine Trial (VACCS)

3:15-3:35 PM

Panel Discussion with Session V Speakers

3:35-3:45 PM


Session VI
Brainstorming and Future Directions

Moderators: Altaf Mohammed, Amit Kumar and Phil Daschner
3:45-4:45 PM

Breakout Panel Discussion I
Breakout Panel Discussion II

4:45-5:30 PM

Reconvene for final discussions

5:25-5:30 PM