Agenda
10:00am - 12:30pm ET
Session 1 - Introduction to COMETS and COMETS Analytics Tutorial
Chair: Krista Zanetti, Ph.D., M.P.H., R.D.N., Office of Nutrition Research, NIH
In this session, we will introduce COMETS and provide a tutorial on using COMETS Analytics for metabolomic epidemiology single cohort and meta-analysis. Participants are encouraged to explore COMETS Analytics in advance and to try out the software during the session (available through GitHub as an R package or through the web-based platform). Time will allow for questions/comments from participants.
- An Introduction to Metabolomic Epidemiology and COMETS
Kelly Crotty, Ph.D., National Cancer Institute, NIH - Streamlining consortium-based analyses of metabolomics data with COMETS Analytics
Ewy Mathé, Ph.D., National Center for Advancing Translational Sciences, NIH
Break 10:45 - 11:00am ET
- Metabolite Name Harmonization and Integrity Checks
Chiraag Gohel, George Washington University - Single Cohort Analyses
Nicole Prince, Ph.D., Harvard Medical School and Brigham and Women's Hospital
Break 11:50 - 11:55am ET
- Meta-Analysis
Ewy Mathé, Ph.D., National Center for Advancing Translational Sciences, NIH - Discussion
Krista Zanetti, Ph.D., M.P.H., R.D.N., Office of Nutrition Research, NIH
Break 12:30 - 1:30pm ET
1:30 - 3:00pm ET
Session 2 - Latest developments in Prospective Analyses of Metabolomic Epidemiology Studies
Chair: Su Chu, Ph.D., Harvard Medical School and Brigham and Women's Hospital
In the first part of this session (50 min), we will have 3 brief scientific talks:
- The Metabolome of BMI: A COnsortium of METabolomics Studies (COMETS) Meta-analysis of 46 diverse cohorts
Rachel Kelly, Ph.D. Harvard University - Leveraging COMETS to Explore Impacts of Caloric Restriction on Metabolomic Aging
Waylon Hastings, Ph.D., Tulane University - A Multi-Cohort Prospective Analysis of Blood Metabolites and Glioma Risk in COMETS
Demetrius Albanes, M.D., National Cancer Institute, NIH
These talks will be followed by a panel discussion (40 min) on how to improve efficiency and reproducibility in metabolomic epidemiology through COMETS. Panelists will include the three speakers and Ewy Mathé. Topics will include (but not be limited to) standardization of metabolite names and covariables, ease of data sharing, bottlenecks when implementing meta-analyses, and facilitating large complex collaborations.