Agenda
Day 1, Monday, October 26, 2020
| 10:00 am - 10:05 am |
Introduction and Overview |
| 10:05 am - 10:20 am | Opening Remarks Norman E. (Ned) Sharpless, M.D. Director, National Cancer Institute |
| 10:20 am - 10:35 am | Opening Remarks Richard Hodes, M.D. Director, National Institute on Aging |
| 10:35 am - 11:05 am | Keynote Speaker Luigi Ferrucci, M.D., Ph.D. Scientific Director, National Institute on Aging, Intramural Research Program |
| Session 1 | Understanding the Molecular Biology of Cancer in Elderly Moderator: Max Guo, Ph.D. National Institute on Aging, Division of Aging Biology |
| 11:05 am - 11:25 am | Anticancer Mechanisms in Long-Lived Mammals Vera Gorbunova, Ph.D. University of Rochester |
| 11:25 am - 11:45 am | Connecting Cancer to Aging – An Evolutionary Perspective James DeGregori, Ph.D. University of Colorado School of Medicine |
| 11:45 am - 12:05 pm | Panel Discussion |
| 12:05 pm - 12:25 pm | Lunch |
| Session 2 | Cellular Senescence in Cancer and Aging Moderator: Basil Eldadah, M.D., Ph.D. National Institute on Aging, Division of Geriatrics and Clinical Gerontology |
| 12:25 pm - 12:45 pm | Mechanisms of Immunosenescence and Immune Response to Vaccines in Elderly Nan-ping Weng, M.D., Ph.D. National Institute on Aging, Laboratory of Molecular Biology and Immunology |
| 12:45 pm - 1:05 pm | Cellular Senescence in Aging and Cancer Darren J. Baker, Ph.D., M.S. Mayo Clinic |
| 1:05 pm - 1:25 pm | Panel Discussion |
| Session 3 | Implication of Oxidative Stress Towards Cancer Biology Moderator: Konstantin Salnikow, Ph.D. National Cancer Institute, Division of Cancer Biology |
| 1:25 pm - 1:45 pm | Gender Effects in Cancer and Aging Vadim Gladyshev, Ph.D. Harvard Medical School and Brigham and Women’s Hospital |
| 1:45 pm - 2:10 pm | Dysregulation of Iron Metabolism in Cancer and Aging Suzy V. Torti, Ph.D. UConn Health |
| 2:05 pm - 2:25 pm | Panel Discussion |
| 2:25 pm - 2:30 pm | Coffee Break |
| Session 4 | Senescence, Immune Response and Cancer in the Elderly Moderators: Matthew Young, Ph.D. National Cancer Institute, Division of Cancer Prevention Anil Wali, PhD. National Cancer Institute, Center to Reduce Cancer Health Disparities |
| 2:30 pm - 2:50 pm | Telomere and Genome Integrity in Cancer and Aging Patricia Opresko, Ph.D. University of Pittsburgh |
| 2:50 pm - 3:10 pm | Inter-Relationship Between Microbiota Diversity, Obesity and Race in Endometrial Cancer Victoria L. Bae-Jump, M.D., Ph.D. UNC Health |
| 3:10 pm - 3:30 pm | Panel Discussion |
| Session 5 | Environmental Factors: The Overlap of Carcinogens/Gerontogens Moderator: Leslie J. Reinlib, Ph.D. National Institute of Environmental Health Sciences |
| 3:30 pm - 3:50 pm | Environmental Chemical Exposures and Biomarkers of Cancer Risk Susan L. Neuhausen, Ph.D. Beckman Research Institute of City of Hope |
| 3:50 pm - 4:30 pm | Breast Cancer in Young and Older Women Melissa Troester, Ph.D. UNC Center for Environmental Health and Susceptibility |
| 4:30 pm - 4:50 pm | Panel Discussion |
| 4:50 pm | Adjourn, Day 1 |
Day 2, Tuesday, October 27, 2020
| 10:00 am - 10:10 am |
Goals and Objectives |
| 10:10 am - 10:40 am | Keynote: Epigenetic Linkage of Aging, Cancer and Nutrition Trygve Tollefsbol, Ph.D., D.O. University of Alabama |
| Session 6 | Potential Impact of Nutrition on Cancer Prevention Moderators: Gabriela Riscuta, M.D., C.N.S. National Cancer Institute, Division of Cancer Prevention Pataje (Pat) Prasanna, Ph.D. National Cancer Institute, Division of Cancer Treatment and Diagnosis |
| 10:40 am - 11:00 am | Senolytic Bioactive Food Components and their Biological Pathway for Action Simin Nikbin Meydani, D.V.M., Ph.D. Tufts University |
| 11:00 am - 11:20 am | Cancer prevention in Elderly and Particularities for Mechanisms of Action Chengguo (Chris) Xing, Ph.D. University of Florida |
| 11:20 am - 11:50 am | The Mechanisms of Fasting and Advanced Glycation End Products in Cancer Prevention in Elderly Sebastian Brandhorst, Ph.D. USC Leaonard Davis School of Gerontology |
| 11:50 am - 12:10 pm | Panel Discussion |
| 12:10 pm - 12:30 pm | Lunch |
| 12:30 pm - 1:00 pm | Keynote: Melanoma Metastasis to Lymph Nodes; Mechanisms and Contributing Factors Sean Morrison, Ph.D. UT Southwestern |
| Session 7 | Cancer Therapeutics and Treatment Optimization for the Elderly Moderators: Weiwei Chen, Ph.D. National Cancer Institute, Division of Cancer Treatment and Diagnosis Christina Liu, Ph.D., P.E. National Cancer Institute, Division of Cancer Treatment and Diagnosis |
| 1:00 pm - 1:20 pm | Age Against the Machine: How the Aging Microenvironment Governs Tumor Progression and Response to Therapy Ashani T. Weeraratna, Ph.D. Johns Hopkins Bloomberg School of Public Health |
| 1:20 pm - 1:40 pm | VLA4-nanoparticles Hijack Cell Adhesion Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival Greg M. Lanza, M.D., Ph.D., F.A.C.C. Washington University School of Medicine, St. Louis |
| 1:40 pm - 2:00 pm | Treatment Optimization for the Elderly with Comorbidities Heidi Diana Klepin, M.D. Wake Forest School of Medicine |
| 2:00 pm - 2:20 pm | Panel Discussion |
| 2:20 pm - 2:30 pm | Wrap Up and Adjourn |