NCI Workshop on Neutron Capture Therapy for Cancer (Agenda)


All times are in ET time zone.

April 20, Session 1. Clinical Trials

(Q/A after the presentations if time allows)                    

Moderators: Akira Matsumura and Sunil Krishnan
9:00 – 9:10 am Welcome Remarks, Jacek Capala, Bhadrasain Vikram, Norm Coleman
9:10 – 9:20 am Overview of BNCT in 2022, Wolfgang Sauerwein
9:20 – 10:50 am Initiatives Towards Clinical BNCT in Japan
  • Introduction, Akira Matsumura
  • Regulatory Issues with PMDA in Japan, Tomoyuki Asano
  • Accelerator-based BNCT for Recurrent Head and Neck Cancer, Katsumi Hirose
  • Accelerator-based BNCT for recurrent glioblastoma, Shinji Kawabata
  • Accelerator-based Boron Neutron Capture Therapy for Skin Tumors, Hiroshi Igaki
  • Progress on Non-clinical Trials Using a Newly Developed Accelerator Neutron Source at the University of Tsukuba, Kei Nakai
10:50 – 11:20 am The Finnish BNCT Experience
  • Setting up a New Accelerator-based NCT Facility, Liisa Porra
  • Clinical Trials, Past and Future, Heikki Joensuu
11:20 – 11:40 am Optimal Design of Future NCT Clinical Trials, Andrea Wittig
11:40 – 12:00 pm Panel Discussion


April 21, Session 2. Delivery Agents

(talks 15 min and discussion 30 min, except the last item with 10 min, each)

Moderators: Graca Vicente and Narayan Hosmane
9:00 – 10:45 am Small Molecules
  • Synthesis and Application of Biology Oriented Boron Chemicals, Bhaskar Das
  • The Uniqueness of Boron Clusters as Challenging Scaffolds to Tackle Cancer by Multitherapies, Clara Vinas
  • Design and Synthesis of Carborane-containing Matrix Metalloproteinase Ligands as Candidates for BNCT, Daniel Becker
  • Carborane-peptide conjugates as selective boron-delivery agents for potential applications in BNCT, Evamarie Hey-Hawkins
  • Boron Delivery using Serum Albumin, Hiroyuki Nakamura
  • Panel Discussion
10:45 – 11:30 am Nanoparticles
  • Boron-rich Liposomes as Nanoscale Delivery Agents for BNCT, Satish Jalisatgi
  • Targeted NanoBoron for BNCT of Malignant Glioma, Rameshwar Patil
  • Panel Discussion
11:30 – 12:00 pm Beyond Boron and Neutrons
  • Boron Compounds for Proton Boron Fusion Therapy, James Welsh
  • Tumor targeted boron and gadolinium incorporated phospholipid molecules for NCT, Jamey Weichert
  • Panel Discussion


April 22, Session 3. Translational Research

(talks 20 min, discussions 15 min)

Moderators: Mandy Schwint and Natsuko Kondo
9:00 – 9:55 am Dosimetry/Reporting
  • New Dosimetry Methods for NCT, Reinhard Schulte
  • NCT Reporting Requirements, Wolfgang Sauerwein
  • Panel Discussion
9:55 – 10:50 am Radiation biology
  • Preclinical Studies to Evaluate Biological Effects of an Accelerator-based BNCT System, Mitsuko Masutani
  • Systems Biology Approach to Investigate Biomarkers, Boron-10 Carriers and Mechanisms Useful for Improving BNCT, PierLuigi Mauri
  • Panel Discussion
10:50 – 11:45 am Optimal Models
  • Rat and Mouse Brain Tumor Models for Experimental Neuro-oncology Research, Rolf Barth
  • Animal Tumor Models for BNCT Studies (Non–Central Nervous System Solid Tumors), Andrea Monti Hughes
  • Panel Discussion
11:45 -12:00 pm Wrap-up/Next Steps, Jacek Capala