Childhood Cancer Data Initiative Annual Symposium (Abstract Registration): Submission #77

Abstract: The Pediatric Proton/Photon Therapy Comparison (PPTC) cohort study is the first large-scale study comparing the risk of second cancers in children treated with proton versus photon radiotherapy. The study has collected treatment records for more than 10,000 pediatric cancer patients from 17 hospitals. Because the cohort data are both large and distributed across multiple databases, we have deployed a cloud-based system to streamline data collection, monitoring, validation, and transfer to a high-performance computing (HPC) cluster. Data for ~7,500 patients have been collected to date in an industry-standard medical imaging format (DICOM), including radiation field parameters, planning computed tomography (CT) images with clinician-delineated anatomical structures, and dose distributions from the treatment planning system (TPS). Another critical component is the development of scalable methods for estimating individualized, organ-level radiation dose for epidemiological dose-response analyses. Planning CT scans typically cover only the treatment region, often omitting organs of interest for late effects research. To address this, we developed a method to extend partial-body CT images using a library of surrogate anatomies. In addition, due to variability and inconsistency in organ delineation and naming, we utilize a deep learning–based automatic segmentation tool to standardize organ delineation. Finally, we address limitations of TPS dose estimates by performing advanced Monte Carlo radiation transport simulations of both modalities. These simulations integrate patient data and detailed physics modeling and are efficiently executed on the NIH HPC cluster. This poster presents our efforts to implement a state-of-the-art dosimetry platform—from data collection to individualized dose calculations.