NCI Office of Data Sharing (ODS) Data Jamboree (Abstract Submissions): Submission #44

Submission information
Submission Number: 44
Submission ID: 145399
Submission UUID: 80719528-8bfc-4137-93fd-289ac9612dcc

Created: Wed, 06/25/2025 - 12:49
Completed: Wed, 06/25/2025 - 12:49
Changed: Wed, 06/25/2025 - 12:49

Remote IP address: 10.208.24.68
Submitted by: Anonymous
Language: English

Is draft: No
First Name Xin
Middle Initial
Last Name Zhou
Degree(s) PhD
Position/Title/Career Status assistant member
Organization St. Jude Children's Research Hospital
Organization Address Memphis
Email xin.zhou@stjude.org
Other (Please Specify)
Abstract Category Employment of statistical methods or existing computational, mathematical, or informatics tools
Abstract Keywords survivorship, epidemiology, genetics
Abstract Title Discover Novel Treatment–associated Late Adverse Effect in Long term survivors of childhood cancer by leveraging the Childhood Cancer Survivorship Portal
Abstract Summary Owing to continued therapeutic improvement and innovation, the number of survivors of childhood cancer in the United States will exceed 580,000 by 2040. However, long-term survivors face a broad spectrum of adverse health outcomes such as subsequent neoplasms and cardiomyopathies. Understanding the association of these long-term adverse outcomes and treatment exposure is critical to advancing survivorship care and optimizing pediatric cancer treatment. To enable the exploration of the survivorship data, we developed Survivorship Portal, a public resource with demographic and clinical data, cancer diagnoses, chemotherapy and radiation exposures, risk-based clinical assessments, laboratory results, patient-reported outcomes, and whole-genome sequencing–derived germline genotypes on 28,500 childhood cancer survivors enrolled in St Jude Life and Childhood Cancer Survivorship Study (CCSS) which include > 1,600 phenotypic variables and 400 million genetic variants (Matt et al, Cancer Discovery 2024)
We propose to utilize the Childhood Cancer Survivorship Portal to investigate novel associations between cancer treatment exposures and late effects across organ systems.
The project will leverage the portal’s rich dataset and interactive analytical tools, to construct exposure–outcome models to assess correlations between treatment regimens and organ-specific late effects. Through the portal's advanced cohort-building tool, the team will identify clinically meaningful survivor subgroups, such as those at elevated risk due to treatment intensity, age at exposure, or genetic susceptibility, thus making more refined and novel analysis. Our team includes postdoctoral trainees in survivorship research and is led by a senior scientist overseeing portal development.
Through this effort, we aim to demonstrate the scientific value and utility of the Survivorship Portal while generating actionable insights for risk stratification and follow-up care in survivors of pediatric cancers. This project will not only advance survivorship research but also promote awareness and adoption of the portal within the broader childhood cancer research community.
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