NCI Office of Data Sharing (ODS) Data Jamboree (Abstract Submissions): Submission #24
Submission information
Submission Number: 24
Submission ID: 145144
Submission UUID: 660f840f-d9cd-482f-9804-f983235cd3de
Submission URI: /nci/ods-data-jamboree/abstractsubmissions
Submission Update: /nci/ods-data-jamboree/abstractsubmissions?token=D6YCSWji5h654cu_Ruwrh0vGxxzv6GcS74ORkgEklLQ
Created: Mon, 06/23/2025 - 12:12
Completed: Mon, 06/23/2025 - 12:12
Changed: Mon, 06/23/2025 - 12:18
Remote IP address: 10.208.28.103
Submitted by: Anonymous
Language: English
Is draft: No
Presenter Information
Fernanda
A.
Silva Michels
MSc, PhD, ODS-C
Epidemiologist - Program Manager of Data Quality and Integration
NAACCR
Springfield
{Empty}
Abstract Information
Building specific disease cohorts, or visualization techniques
COG, NCCR Data Platform, Neuroblastoma, Survival, Trials enrollment.
Survival Disparities among Children Diagnosed with Neuroblastoma Enrolled and Not Enrolled in COG Clinical Trials Using the NCCR Data Platform
Group: Fernanda Silva Michels (NAACCR),
Gonçalo Forjaz (Westat),
Stephanie Hill (NAACCR)
Background
A 2025 Children’s Oncology Group (COG) study1 found that Black and Hispanic children with high-risk neuroblastoma had worse overall survival (OS), even when treated with the same standardized protocols on frontline COG clinical trials. The mechanisms explored in the study did not fully account for the observed disparities in survival.
With the NCCR Data Platform, we now have the opportunity to examine whether similar patterns exist among children who did not participate in a COG clinical trial.
Methods
The NCCR Data Platform links Surveillance, Epidemiology, and End Results (SEER) population-based cancer registry data from 1995 to 2021, representing 57.6% of all US children, adolescents and young adults, and data from patients enrolled in COG studies from 2007 to 2018, including clinical trials and registry protocols. For this study, we will use SEER population-based cancer registry data from 2007 to 2018 to align with the available COG data. Survival rates will be estimated using Kaplan-Meier analysis. Univariate analysis will be performed with the log-rank test, and multivariate analysis will utilize Cox proportional hazards regression to identify factors associated with overall survival (OS). The analysis will be performed using SEER*Stat and RStudio.
Results/Conclusion
This analysis will help determine whether racial and ethnic disparities in survival among children with neuroblastoma extend beyond the clinical trial population. By comparing outcomes in trial and non-trial settings, we aim to better understand the role of broader contextual and systemic factors. Results may inform future strategies to improve equity in pediatric oncology outcomes. This study will also highlight the depth and utility of the NCCR Data Platform as a resource for population-based cancer research.
Gonçalo Forjaz (Westat),
Stephanie Hill (NAACCR)
Background
A 2025 Children’s Oncology Group (COG) study1 found that Black and Hispanic children with high-risk neuroblastoma had worse overall survival (OS), even when treated with the same standardized protocols on frontline COG clinical trials. The mechanisms explored in the study did not fully account for the observed disparities in survival.
With the NCCR Data Platform, we now have the opportunity to examine whether similar patterns exist among children who did not participate in a COG clinical trial.
Methods
The NCCR Data Platform links Surveillance, Epidemiology, and End Results (SEER) population-based cancer registry data from 1995 to 2021, representing 57.6% of all US children, adolescents and young adults, and data from patients enrolled in COG studies from 2007 to 2018, including clinical trials and registry protocols. For this study, we will use SEER population-based cancer registry data from 2007 to 2018 to align with the available COG data. Survival rates will be estimated using Kaplan-Meier analysis. Univariate analysis will be performed with the log-rank test, and multivariate analysis will utilize Cox proportional hazards regression to identify factors associated with overall survival (OS). The analysis will be performed using SEER*Stat and RStudio.
Results/Conclusion
This analysis will help determine whether racial and ethnic disparities in survival among children with neuroblastoma extend beyond the clinical trial population. By comparing outcomes in trial and non-trial settings, we aim to better understand the role of broader contextual and systemic factors. Results may inform future strategies to improve equity in pediatric oncology outcomes. This study will also highlight the depth and utility of the NCCR Data Platform as a resource for population-based cancer research.