NCI Division of Cancer Biology Junior Investigators Meeting (Abstract): Submission #9

serial: '9'
sid: '193698'
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data:
  category: 'Consider my abstract for a Methodology/Technology presentation'
  degree_s_: 'M.D. Ph.D.'
  email: syparkmd@stanfrod.edu
  first_name: Seongyeol
  keywords_abstracts: ''
  last_name: Park
  middle_initial: ''
  organization: 'Stanford University'
  organization_address:
    address: ''
    address_2: ''
    city: 'Stanford, CA'
    country: ''
    postal_code: ''
    state_province: ''
  summary: |-
    I am a computational biologist with a strong interest in cancer evolution, particularly in how intrinsic and extrinsic factors shape the evolutionary trajectories of tumors. My research aims to understand how genomic instability, mutational processes, and the tumor microenvironment jointly influence cancer progression and clonal dynamics.

    Over the past ten years, I have developed extensive expertise in DNA sequencing data analysis, including the identification and characterization of point mutations, structural variations, copy number alterations, and mutational signatures. This experience has given me a solid foundation for dissecting the genomic landscape of tumors and interpreting the evolutionary processes underlying cancer development.

    In addition to genomic analysis, I have substantial experience in transcriptomic profiling, including bulk RNA sequencing and single cell RNA sequencing, which has allowed me to investigate gene expression heterogeneity both within tumors and across their surrounding cellular context.

    More recently, my research has focused on cancer and tumor microenvironment (TME) interactions, with a particular emphasis on spatial transcriptomics. Using spatial transcriptome analysis, I aim to reveal how the spatial organization of tumors affects cell to cell communication, immune evasion, and clonal selection.

    By integrating genomic, transcriptomic, and spatial data, I seek to build a comprehensive picture of how cancer evolves under selective pressures arising from both intrinsic genomic alterations and extrinsic factors within the tumor microenvironment. I look forward to discussing this integrative approach and exploring collaborative opportunities related to cancer evolution and TME research at this conference.
  title: Postdoc
  ttile: 'Decoding Cancer Evolution: Integrating Genomic, Transcriptomic, and Spatial Approaches to Intrinsic and Extrinsic Drivers'