Symposium on Mutation Signatures in Cancer (Overview)


Welcome to the National Cancer Institute (NCI) Symposium on Mutation Signatures and Cancer, which will be held on December 2-3, 2021 in a virtual format. The symposium will be chaired by Dr. Ludmil Alexandrov (University of California, San Diego) and Dr. Maria Teresa Landi (NCI).

The recent wealth of genomic data has enabled the identification of mutation signatures in a wide range of normal and tumor cells. Progress in this area has been accelerated by computational methods and experimental approaches to link exogenous (e.g. chemical mutagen) and endogenous (e.g. DNA repair defect) factors to specific mutation patterns. The understanding and application of mutation signatures has increased our knowledge of cancer etiology, population exposures, mutagenic processes and treatment response.

This symposium will cover the state of the science of mutation signatures in several key areas: normal and cancer tissues, exogenous and endogenous processes, analytical approaches, and translational aspects.

Registration is free and required to receive a meeting link. Registration closes on November 24, 2021. For conference related questions, please contact

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