Cluster Randomized Trial Designs in Cancer Care Delivery Research - Resources



Campbell, M. J., & Walters, S. J. (2014). How to design, analyse and report cluster randomised trials in medicine and health related research. John Wiley & Sons.

Donner, A., Klar, N. (2010). Design and Analysis of Cluster Randomization Trials in Health Research. United Kingdom: Wiley.

Eldridge, S., & Kerry, S. (2012). A practical guide to cluster randomised trials in health services research. John Wiley & Sons.

Hayes, R. J., & Moulton, L. H. (2017). Cluster Randomised Trials. Chapman and Hall/CRC.

Matthews, J. N. (2006). Introduction to Randomized Controlled Clinical Trials. United Kingdom: CRC Press.

Murray, D. M. (1998). Design and Analysis of Group-randomized Trials. United Kingdom: Oxford University Press.


Cluster Randomized Trials: Facilitating Quality Trials and Methodological Research. Queen Mary University of London.

NIH Pragmatic Trials Collaboratory: Rethinking Clinical Trials®.  Section 3: Cluster Randomized Trials:

Pragmatic and Group-Randomized Trials in Public Health and Medicine: Online Course. Office of Disease Prevention, National Institutes of Health.

Research Methods Resources, National Institutes of Health.


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Web Resources For Design And Analysis Of Multiple Period Cluster Randomized Trials

Sample size calculation resources:

A shiny app to find a sample size calculator that has the features you need:

Main app-based calculators for sample size calculation

Other sample size calculation resources:

R and SAS code used to perform the sample size calculation for worked examples in the presentation

Planning special SW designs:

Continuous recruitment designs:

Staircase designs:

SW-CRT with subclusters:

General apps to inform design:

Information content – the impact of different periods, sequences, and cluster-period cells on power

Examining the impact of misspecification of the correlation structure on inferences:

Databank of real ICC/CAC values for trials with continuous outcomes: