Statistical Adjustment for Multiplicity Workshop (Agenda)

Agenda

Day 1 – Wednesday, October 26, 2022, 9:00 am - 3:00 pm ET
9:00-9:10 am	Welcome and Introductory Remarks View Session Recording Philip E. Castle, PhD, MPH, Division of Cancer Prevention (DCP), National Cancer Institute (NCI)
9:10-9:25 am	Overview and Workshop Objectives View Session Recording Victor Kipnis, PhD, DCP, NCI
9:25-10:10 am	Keynote: A Broad View of Multiplicity Adjustment View Session Recording Yoav Benjamini, PhD, Tel Aviv University Selective inference issues in medical research: Science and Politics
10:10-10:40 am	Break
10:40 am-12:10 pm	Session 1: When to Adjust for Multiplicity View Session Recording Moderator: Victor Kipnis, PhD, DCP, NCI Presenters: Andrew Vickers, PhD, Memorial Sloan Kettering Cancer Center Adjusting for multiplicity in clinical trials and observational studies is critical and absolutely must be done Constantine Gatsonis, PhD, Brown University Multiplicity of inferences in medical research: Accounting and Reporting Sander Greenland, MA, MS, DrPH, University of California, Los Angeles Multiple comparisons controversies are about context and costs
12:10-12:30 pm	Panel Q&A: Session 1 Speakers & Joseph Unger, PhD, MS, Fred Hutchinson Cancer Center View Session Recording
12:30-1:00 pm	Break
1:00-2:30 pm	Session 2: How to Adjust for Multiplicity View Session Recording Moderator: Grant Izmirlian, PhD, DCP, NCI Presenters: Luke Miratrix, PhD, Harvard University A quick overview and comparison of methods to adjust tests on a modest number of outcomes Jason Hsu, PhD, The Ohio State University To adjust (or not to adjust) for Multiplicity of decision paths, endpoints, subgroups, and tumor types Daniel Yekutieli, PhD, Tel Aviv University Empirical Bayes methodology for multiplicity adjustment
2:30-2:50 pm	Panel Q&A: Session 2 Speakers View Session Recording
2:50-3:00 pm	Wrap up
3:00 pm	Adjourn

Day 2 – Thursday, October 27, 2022, 10:00 am - 2:00 pm ET
10:00-10:10 am	Welcome Back View Session Recording Vance Berger, PhD, DCP, NCI Grant Izmirlian, PhD, DCP, NCI
10:10-11:40 am	Session 3: How to Power Multiple Testing Studies View Session Recording Moderator: Vance Berger, PhD, DCP, NCI Presenters: Peng Liu, PhD, Iowa State University Power multiple testing in Omics studies Kristen Hunter, PhD, Harvard University The power under Multiplicity project: An R package for calculating power for multilevel experiments Sin-Ho Jung, PhD, Duke University Sample size calculations for FDR control
11:40 am-12:00 pm	Panel Q&A: Session 3 Speakers View Session Recording
12:00-12:30 pm	Break
12:30-1:30 pm	Panel Discussion View Session Recording Moderator: Victor Kipnis, PhD, DCP, NCI Panelists: Grant Izmirlian, PhD, DCP, NCI Dan Kluger, Stanford University Luke Miratrix, PhD, Harvard University Joseph Unger, PhD, MS, Fred Hutchinson Cancer Center Kevin Dodd, PhD, DCP, NCI All speakers are invited to join
1:30-2:00 pm	Workshop Recap and Next Steps View Session Recording Vance Berger, PhD, DCP, NCI Grant Izmirlian, PhD, DCP, NCI
2:00 pm	Adjourn