Annual Meeting of the NCI Cohort Consortium (Abstract Submission): Submission #14
Submission information
Submission Number: 14
Submission ID: 127589
Submission UUID: 087bc485-6347-4ec5-81ac-7e873aa76c7a
Submission URI: /egrp/cohortconsortium/abstracts
Submission Update: /egrp/cohortconsortium/abstracts?token=nekiEr3VkmTedzqSuN64J3IYa4sENn8cgNB3-P5ipk4
Created: Fri, 09/13/2024 - 19:03
Completed: Fri, 09/13/2024 - 19:06
Changed: Mon, 09/16/2024 - 16:40
Remote IP address: 10.208.24.118
Submitted by: Anonymous
Language: English
Is draft: No
Webform: Cohort 2024 (Abstracts Submission)
Lightning Talks Abstract
Liliana
Gomez-Flores-Ramos
Professor
Ph.D.
CONAHCYT-National Institute of Public Health, Mexico
Added Sugar Intake and Breast Cancer Risk: Findings from the Mexican Teachers' Cohort
Background: Mexico has a high consumption of added sugars (AS), and previous have suggested a potential link between carbohydrate intake and breast cancer (BC) incidence in Mexico. However, this association has not been confirmed in a prospective study. We aimed to estimate the effect of AS intake on BC in the Mexican Teachers’ Cohort.
Methods: We assessed diet in 89,879 BC-free women using a validated FFQ in the 2006-2008 baseline assessment. We estimated AS using a standardized procedure. BC diagnoses from baseline to December 2019 were validated using electronic health records and cancer and mortality registries. The data was analyzed using adjusted multivariable Cox regression models and AS was modeled with restricted cubic splines. Women were categorized based on their daily AS intake (< 31 g/d, 31-60 g/d, 61-90 g/d, and over 91 g/day) as per the EAT-Lancet recommendation. We calculated the estimates for overall, premenopausal, and postmenopausal BC.
Results: The median AS intake was 52g/day (IQR 36-77), and 1,313 BC cases were confirmed over a median follow-up of 10.9 years. Overall, a nonlinear dose-response relationship with limited HR elevation was observed. For premenopausal BC, HR peaked at 1.4 and remained relatively stable after 50g/day. Compared to women in the lowest category of AS (≤31 g/day), women in the highest category (≥ 91g/day) had a higher incidence of BC (HR=1.34, 95%CI 0.93, 1.92). No significant increase was observed for postmenopausal women.
Conclusion: Our findings suggest that AS may play a role in the incidence of premenopausal BC in Mexican women.
Methods: We assessed diet in 89,879 BC-free women using a validated FFQ in the 2006-2008 baseline assessment. We estimated AS using a standardized procedure. BC diagnoses from baseline to December 2019 were validated using electronic health records and cancer and mortality registries. The data was analyzed using adjusted multivariable Cox regression models and AS was modeled with restricted cubic splines. Women were categorized based on their daily AS intake (< 31 g/d, 31-60 g/d, 61-90 g/d, and over 91 g/day) as per the EAT-Lancet recommendation. We calculated the estimates for overall, premenopausal, and postmenopausal BC.
Results: The median AS intake was 52g/day (IQR 36-77), and 1,313 BC cases were confirmed over a median follow-up of 10.9 years. Overall, a nonlinear dose-response relationship with limited HR elevation was observed. For premenopausal BC, HR peaked at 1.4 and remained relatively stable after 50g/day. Compared to women in the lowest category of AS (≤31 g/day), women in the highest category (≥ 91g/day) had a higher incidence of BC (HR=1.34, 95%CI 0.93, 1.92). No significant increase was observed for postmenopausal women.
Conclusion: Our findings suggest that AS may play a role in the incidence of premenopausal BC in Mexican women.