Oncology Models Forum Annual Meeting (Agenda)

Oncology Models Forum Annual Meeting Agenda

 

 

View: Day 1 | Day 2 | Day 3

Day 1

DATE: Tuesday, March 30, 2021
TIME: 11:00 am – 4:30 pm EST
WebEx Link
PW: Tuesday1!

Time Title Speaker
11:00 am Welcome and Introduction Joanna Watson, PhD
NCI
Session 1: Application and Credentialing of Novel Technologies
11:10 am – 11:30 am Preclinical models of metastatic gastric cancer reveal new principles of immune surveillance
PI: Scott Lowe, PhD
Sloan Kettering Institute
Josef Leibold, PhD
University of Tubingen
11:30 am – 11:50 am Rapid Interrogation of Cancer Variants using Base Editing Screens
PI: Lukas Dow, PhD
Weill Cornell Medicine
Bianca Diaz
Weill Cornell Medicine
11:50 am – 12:10 pm Partnering with patients to discover dependencies of rare tumors
PI: Jesse S. Boehm, PhD
Broad Institute
Jesse S. Boehm, PhD
Broad Institute
12:10 pm – 12:30 pm Multimodal Functional Imaging of Heterogeneity in Patient-Derived Models of Head and Neck Cancer
PI: Mukund Seshadri, PhD
Roswell Park Comprehensive Cancer Center
Mukund Seshadri, PhD
Roswell Park Comprehensive Cancer Center
Session 1: Flash Talks
12:30 pm – 12:35 pm Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution
PI: Anirban Maitra, MBBS
MD Anderson Center
Maria Monberg
MD Anderson Center
12:35 pm – 12:40 pm Imaging studies in a preclinical model of pancreatic cystic neoplasia
PI: Anirban Maitra, MBBS
MD Anderson Center
Sonja Woermann, PhD
MD Anderson Center
12:40 pm – 12:45 pm Credentialing Patient-derived Organoid Models of Head and Neck Cancer
PI: Mukund Seshadri, DDS, PhD
Roswell Park Comprehensive Cancer Center
Vincent Vui King Chong, PhD
Roswell Park Comprehensive Cancer Center
12:45 pm – 12:50 pm Living tissue imaging-based dependency biosensors for gastroesophageal tumors
PI: Jesse Boehm, PhD
Broad Institute
Mushriq Al-Jazrawe
Broad Institute
12:50 pm – 12:55 pm A Novel Pre-Clinical Model to Further Understand Role of Immunity in Cervical Cancer
PI: T.-C. Wu, MD, PhD
Johns Hopkins University
Talia Henkle, PhD
Johns Hopkins University
12:55 pm – 1:15 pm BREAK (20 minutes)  
Session 2: Models for Credentialing Cancer Biology and the Microenvironment
1:15 pm – 1:35 pm Modeling K-Ras allelic variation in mice
PI: Kevin Haigis, PhD
Dana Farber Cancer Institute
Kevin Haigis, PhD
Dana Farber Cancer Institute
1:35 pm – 1:55 pm Highly penetrant and immunogenic mouse models of non-viral HCC that are suitable for evaluation of immune checkpoint inhibitors
PI: Michael Karin, PhD
University of California, San Diego
Michael Karin, PhD
University of California, San Diego
1:55 pm – 2:15 pm Interrogating cellular heterogeneity in liver regeneration and cancer
PI: Hao Zhu, MD
Children’s Medical Center Research Institute at UT Southwestern
Hao Zhu, MD
Children’s Medical Center Research Institute at UT Southwestern
2:15 pm – 2:35 pm Expansion of tumoroid models for precise treatment of the rectal cancer patient
PI: Josh Smith, MD
Memorial Sloan Kettering Cancer Center
Brian Szeglin
Memorial Sloan Kettering Cancer Center
Session 2: Flash Talks
2:35 pm – 2:40 pm Modeling necrosis and the tumor microenvironment in glioblastoma to improve therapeutic targeting
PI: Dan Brat, MD
Northwestern University
Steve Markwell, PhD
Northwestern University
2:40 pm – 2:45 pm Improving hepatocellular carcinoma mouse modeling by understanding the malignant potential and biology of liver cell subpopulations
PI: Hao Zhu, MD
Children’s Medical Center Research Institute at UT Southwestern
Andrew Chung
Children’s Medical Center Research Institute at UT Southwestern
2:45 pm – 2:50 pm Modeling acute inflammation in Patient Derived Xenografts (PDX) of Chronic Myelomonocytic Leukemia (CMML)
PI: Eric Padron, MD
Moffitt Cancer Center
Hannah Newman
Moffitt Cancer Center
2:50 pm – 3:10 pm BREAK (20 minutes)  
Session 3: Models for Predicting and Evaluating Therapies
3:10 pm – 3:30 pm Development of combination regimens for myeloid malignancies in humanized mice
Leighton Grimes, PhD, Cincinnati Children’s Hospital
Stephanie Helene, MD, Yale University
Stephanie Helene, MD
Yale University
3:30 pm – 3:50 pm Modeling necrosis and the tumor microenvironment in glioblastoma to improve therapeutic targeting
PI: Daniel Brat, PhD
Northwestern University
Daniel Brat, PhD
Northwestern University
3:50 pm – 4:10 pm Credentialling a genetically engineered clinically relevant mouse model of multiple myeloma
PI: Marta Chesi, PhD
Mayo Clinic
Marta Chesi, PhD
Mayo Clinic
4:10 pm – 4:30 pm Rescue of cognitive function following fractionated brain irradiation in a novel preclinical glioma model
PI: Susanna Rosi, PhD and Nalin Gupta, MD
University of California San Francisco
Nalin Gupta, MD, PhD
University of California San Francisco
4:30 pm Wrap-up  

 

 

View: Day 1 | Day 2 | Day 3

DAY 2

DATE: Wednesday, March 31, 2021
TIME: 11:00 am – 5 pm EST
WebEx Link
PW: Wednesday1!

Time Title Speaker
11:00 am Welcome Joanna Watson, PhD
NCI
Session 4: Models for Predicting and Evaluating Therapies, continued
11:10 am – 11:30 am Integration of high dimensional datasets in an immunocompetent mammary mouse model
PI: Mary Helen Barcellos-Hoff, PhD
University of California, San Francisco
Mary Helen Barcellos-Hoff, PhD
University of California, San Francisco
11:30 am – 11:50 am Investigating cancer immunology using the NINJA model
PI: Nikhil Joshi, PhD
Yale University School of Medicine
Nikhil Joshi, PhD
Yale University School of Medicine
11:50 am – 12:10 pm Polymerase-based ultramutagenesis in animal cancer models
PI: Diego Castrillon, Ph.D.
UT Southwestern Medical Center
Diego Castrillon, Ph.D.
UT Southwestern Medical Center
Session 4: Flash Talk
12:10 pm – 12:15 pm Patient-Derived Cell Modeling Neuroendocrine Tumors
PI: Xuefeng Liu, PhD
Georgetown University
Seema Agarwal, PhD
Georgetown University
12:15 pm – 12:35 pm BREAK (20 minutes)  
Session 5: Credentialing in Non-Mouse Models
12:35 pm – 12:55 pm A novel adenoviral-permissive, immunocompetent hamster model to evaluate oncolytic adenoviral therapy for glioblastoma
PI: Frederick Lang, MD
MD Anderson Center
Frederick Lang, MD
The University of Texas, MD Anderson CancerCenter
12:55pm – 1:15 pm Porcine Models of Pancreatic Cancer
PI: Mark Carlson, MD
University of Nebraska Medical Center
Mark Carlson, MD
University of Nebraska Medical Center
1:15 pm – 1:35 pm Human basal-like breast cancer is represented by one of the two intrinsic mammary cancer subtypes in dogs
PI: Shaying Zhao, PhD
University of Georgia
Shaying Zhao, PhD
University of Georgia
1:35 pm – 1:55 pm Dog as a comparative model for cancer
PI: Kerstin Lindbald-Toh, PhD
Broad Institute of MIT and Harvard
Kerstin Lindbald-Toh, PhD
Broad Institute of MIT and Harvard
1:55 pm – 2:15 pm Advancing blood biopsy through the canine comparative model
PI: Elinor Karlsson, PhD
Broad Institute of MIT and Harvard
Elinor Karlsson, PhD
Broad Institute of MIT and Harvard
Session 5: Flash Talks
2:15 pm – 2:20 pm Canine Osteosarcoma as a Model of DMD Deletion
PI: Elinor Karlsson, PhD
Broad Institute of MIT and Harvard
Heather Gardner, PhD, DVM, DACVIM
Broad Institute of MIT and Harvard
2:20 pm – 2:25 pm Enabling comparative genomics through a machine learning classifier for human and canine cancers
PI: Elinor Karlsson, PhD
Broad Institute of MIT and Harvard
Kate Megquier, PhD
Broad Institute of MIT and Harvard
2:25 pm – 2:45 pm BREAK (20 minutes)  
Session 6: PRECINCT – Pre-medical Cancer Immunotherapy Network Canine Trials
2:45 pm – 3:05 pm Introduction to Comparative Oncology Program Amy LeBlanc, DVM DACVIM
NCI
3:05 pm – 3:25 pm Introduction to PRECINCT Nicola Mason, PhD, BVM
University of Pennsylvania
3:25 pm – 3:45 pm Enhancing the efficacy of immunotherapy in diffuse large B cell lymphoma (DLBCL) using rational combination approaches
PI: Cheryl London, DVM, PhD
Tufts Cummings School of Veterinary Medicine
Cheryl London, DVM, PhD
Tufts Cummings School of Veterinary Medicine
3:45 pm – 4:05 pm Modulation of autophagy and apoptosis in doxorubicin treated canine cardiac slices
PI: Cheryl London, DVM, PhD
Tufts Cummings School of Veterinary Medicine
Vicky Yang, DVM, PhD
Tufts Cummings School of Veterinary Medicine
4:05 pm – 4:25 pm Immunotherapy Trial in Pet Dogs with High-grade Glioma Promotes Translation to Phase I Human Glioblastoma Trial
PI: Michael Olin, PhD
University of Minnesota
Michael Olin, PhD
University of Minnesota
4:25 pm – 4:45 pm Comparable Safety and Efficacy Challenges for CAR-T Therapy in Human and Canine Patients with B cell Malignancies
PI: Nicola Mason, PhD, BVM
University of Pennsylvania
Nicola Mason, PhD, BVM
University of Pennsylvania
4:45 pm – 5:00 pm Discussion: Moderated by Amy Leblanc  
5:00 pm Wrap-up  

 

 

View: Day 1 | Day 2 | Day 3

DAY 3

DATE: Thursday, April 8, 2021
TIME: 11:00 am – 4 :15pm EST
WebEx Link
PW: Thursday1!

Time Title Speaker
11:00 am Welcome Joanna Watson, PhD
Division of Cancer Biology, NCI
Session 7: Models for Credentialing Immune Functions and Responses
11:10 am – 11:30 am Visualizing tumor heterogeneity in an immune intact and autochthonous mouse model of breast cancer
PI: Joshua Snyder, PhD
Duke University Medical Center
Joshua Snyder, PhD
Duke University Medical Center
11:30 am – 11:50 am Intravesical dendritic cell targeting with Fc-enhanced CD40 agonistic antibodies induces durable bladder cancer immunity
PI: Stylianos Bournazos, PhD
Rockefeller University
Christopher Garris, PhD
Rockefeller University
11:50 am – 12:10 pm Precision medicine outside the patient: a humanized mouse model to study cancer immunobiology
PI: Ryan Fields, PhD
Washington University School of Medicine
Michael Chiorazzi, MD, PhD
Yale School of Medicine
12:10 pm – 12:30 pm Single-Cell RNA sequencing reveals evolution of immune landscape during murine Glioblastoma progression
PI: Alain Charest, PhD
Beth Israel Deaconess Medical Center
Alain Charest, PhD
Beth Israel Deaconess Medical Center
12:30 pm – 12:50 pm BREAK (20 minutes)  
Session 8 : Profiling PDX Preclinical Models
12:50 pm – 1:10 pm Patient-derived xenograft models for rare pediatric cancers: genomics and therapy response
PI: Alejandro Sweet-Cordero, MD
University of California San Francisco
Alejandro Sweet-Cordero, MD
University of California San Francisco
1:10 pm – 1:30 pm Molecular and metabolic profiling of brain tumor patients and preclinical models
PI: David Nathanson, PhD and Thomas Graeber, PhD
University of California Los Angeles
David Nathanson, PhD
University of California Los Angeles
1:30 pm – 1:50 pm Patient-Derived Cell Modeling Neuroendocrine Carcinoma
PI: Xuefeng Liu, PhD
Ohio State University
Xuefeng Liu, PhD
Ohio State University
1:50 pm – 2:10 pm Overcoming resistance to anti-BCMA immunotherapy in myeloma
PI: Marta Chesi, PhD
Mayo Clinic
Marta Chesi, PhD
Mayo Clinic
Session 7: Flash Talks
2:10 pm – 2:15 pm Mouse modelling of HPV infection
PI: Chien-Fu Hung, PhD, and Richard Roden, PhD
The Johns Hopkins University
Pola Olczak
The Johns Hopkins University
2:15 pm – 2:20 pm Engraftment phenotypes of preclinical model systems reveal a subgroup of microenvironment-dependent brain tumors
PI: David Nathanson, PhD
University of California Los Angeles
Nicholas Bayley
University of California Los Angeles
2:20 pm – 2:40 pm BREAK (20 minutes)  
Session 8: CIRP – Cancer Imaging Resource Program
2:40 pm – 2:50 pm Introduction to CIRP Charles Manning, PhD
Vanderbilt University
2:50 pm – 3:02 pm Employing a Primary Mouse Model of Soft Tissue Sarcoma to Study Combined Radiotherapy with Immune Checkpoint Blockade in a Co-Clinical Trial Mirroring SU2C-SARC032
PI: Yvonne Mowery, MD, PhD
Duke University
Yvonne Mowery, MD, PhD
Duke University
3:02 pm – 3:14 pm Co-clinical phenotyping of tumor heterogeneity to predict response to therapy
PI: Kooresh Shoghi, PhD
Washington University School of Medicine
Kooresh Shoghi, PhD
Washington University School of Medicine
3:14 pm – 3:26 pm Pancreatic Cancer Stroma in GEM Models Characterized by MRI and IHC
PI: Rong Zhou, PhD
University of Pennsylvania
Rong Zhou, PhD
University of Pennsylvania
3:26 pm – 3:38 pm Interrogating the impact of microenvironment on SCNC PCa PDX using MRI
PI: Renuka Siriam, PhD
University of California San Francisco
Renuka Siriam, PhD
University of California San Francisco
3:38 pm – 3:50 pm MRI Imaging of Awake Mice: Current Efforts, Applications, and a simple Holder Design for Bruker Systems
PI: Robia Pautler, PhD
Baylor College of Medicine
Robia Pautler, PhD
Baylor College of Medicine
3:50 pm – 4:02 pm MDACC PREDICT: Development of PET Imaging Biomarkers of Glutamine Metabolism through Co-Clinical Trials
PI: Allison Cohen, PhD
Vanderbilt University
Allison Cohen, PhD
Vanderbilt University
4:02 pm – 4:14 pm Investigating Bone Marrow Environment with MRI
PI: Gary Luker, PhD
University of Michigan
Gary Luker, PhD
University of Michigan
4:14 pm – 4:30 Discussion: Moderated by CIRP  
4:30 pm - 5:00 pm Wrap-up