Division of Cancer Prevention (DCP) Immunology Interest Group presents
Immune surveillance of tissue stem cells in steady state, early transformation and beyond
Dr. Agudo obtained her PhD in Regenerative Medicine in the University Autonomous of Barcelona in Spain. As a Fulbright scholar, she performed her postdoctoral training in immunology in the Icahn School of Medicine at Mount Sinai in New York City studying dendritic cell biology and T cell function and creating new mouse models to study immune surveillance. She is currently an Associate Professor of Immunology at the Dana-Farber Cancer Institute and Harvard Medical School. The Agudo lab is exploring how immune cells interact with tissue stem cells upon acquisition of oncogenic mutations at the cusp of tumor initiation, as well as immune evasion of metastatic stem cells -the initiating seeds of metastatic recurrence-. The goal of these studies is to uncover the cellular and molecular underpinnings of tumor initiation and evolution under immune pressure to identify new potential avenues to improve responses to cancer immunotherapy and to discover possible mechanisms for interventions to prevent primary cancer and metastasis. Additionally, the Agudo lab is studying how to protect stem cell derived grafts from autoimmune attack. Dr. Agudo has received the Susan G. Komen Research Career Catalyst award, the Department of Defense Breast Cancer Research Program Era of Hope, the New York Stem Cell-Robertson Investigator award and the Cancer Research Institute Lloyd J. Old STAR award. Dr. Agudo is a and a member of the Parker Institute for Cancer Immunotherapy.
Contact Information:
Seminar questions: Shizuko Sei, MD - seis@nih.gov
Web series questions: Anda Vlad, MD, PhD - anda.vlad@nih.gov
Administrative contact:
Wosene Asefa - wosene.asefa@nih.gov
Juan Miguel Villanueva - juan.villanueva@nih.gov
Registration