The National Cancer Institute
Division of Cancer Biology
Patient Derived Models of Cancer Consortium
Annual Meeting 2022
Division of Cancer Biology
Patient Derived Models of Cancer Consortium
Annual Meeting 2022
November 29–30, 2022
Virtual Event
Agenda
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November 29th, 2022 Noon-5pm EST
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| 12:00 – 12:10 p.m. | Konstantin Salnikow - Welcome, Overview of meeting Day 1 |
| 12:10 -12:15 p.m. | Jonathan Brody (OHSU) - Introduction of Keynote Speaker |
| 12:15 -12:45 p.m. | Keynote speaker Andrew Ewald (Johns Hopkins) |
| Session 1 Chair – Anita Hjelmeland |
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| 1:00 – 1:30 p.m. | PI:Paul Robson(JAX) - “Human Models of Pancreatic Cancer” |
| 1:30 – 1:40 p.m. | Trainee: Giuseppina Caligiuri (CSHL) - “New CAF subtypes in Pancreatic Cancer” |
| 1:40 – 2:10 p.m. | PI: Sean Morrison (UTSW) - “Melanoma metastasis” |
| 2:10 – 2:20 p.m. | Trainee: Thomas Mathews (UTSW) - “Metabolic adaptation in melanoma” |
| 2:20 – 2:30 p.m. | Break 1 |
| Session 2 Chair - Rosie Sears (OHSU) |
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| 2:30 – 3:00 p.m. | PI: Jonathan Brody (OHSU) - “One center’s experience with developing PDMCs for pancreatic cancer to enhance future translational research” |
| 3:00– 3:10 p.m. | Trainee: Motoyuki Tsuda - “Comparing PDMC responses to patient tumor responses in a window-of-opportunity trial for patients with metastatic PDAC” |
| 3:10– 3:40 p.m. | PI: Xiao-Nan Li (Northwestern) - “Matching panels of organoid and orthotopic PDX models of pediatric brain tumors |
| 3:40 - 3:50 p.m. | Trainee: Milagros MS Palacios (Northwestern) - “Customized organoid media for organoid development of brain tumors of different locations” |
| 3:50 - 4:00 p.m. | Break 2 |
| Session 3 Chair: K-T Varley (Utah) |
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| 4:00 - 4:30 p.m. | PI: Bryan Welm (Utah) - “Current strategies and future directions of breast cancer PDMCs” |
| 4:30 – 4:40 p.m. | Trainee: Zannel Blanchard (Utah) - “Breast cancer PDMC model development and analysis at the University of Utah” |
| 4:40 – 5:00 p.m. | PIs from Day 1 presentations lead discussion on “Challenges and next steps” |
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November 30th, 2022 Noon-5pm EST
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| 12:00 -12:10 p.m. | Konstantin Salnikow - Welcome, Overview of meeting Day 2 |
| 12:10 – 12:15 p.m. | Christopher Willey (UAB) - Introduction of Keynote Speaker |
| 12:15 – 12:45 p.m. | Keynote speaker Alice Soragni (UCLA) |
| Session 4 Chair- Don Nguyen (Yale) |
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| 1:00 - 1:30 p.m. | PI: Christopher D. Willey (UAB) - “Update on UAB Glioblastoma PDMC Program” |
| 1:30 – 1:40 p.m. | Trainee: Andee Beierle (UAB) - “Three Dimensional Bioprinting of Glioblastoma Patient-Derived Tumors” |
| 1:40 – 2:10 p.m. | PI: Katerina A. Politi (Yale) - “Mechanisms of TKI persistence uncovered using patient-derived models” |
| 2:10 – 2:20 p.m. | Trainee: Caro Kravitz (Yale) - “The H3K36 Demethylase KDM2A is a Multifunctional Regulator of LUAD Metastasis” |
| 2:20 – 2:30 p.m. | Break 1 |
| Session 5 Chair- Yu Chen (MSKCC) |
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| 2:30 – 3:00 p.m. | PI: Nora Navone (MDA) - “Integrative analysis of the MD Anderson Prostate Cancer Patient-Derived Xenograft Series (MDA PCa PDX)” |
| 3:00 – 3:10 p.m. | Trainee: Estefania labanca (MDA) - “The role of Wnt canonical pathway in prostate prostate cancer progression” |
| 3:10 – 3:40 p.m. | PI: Shiaowen David Hsu (Duke) - "MicroOrganoSphere as a Precision Oncology Platform in CRC" |
| 3:40 – 3:50 p.m. | Trainee: Kun Xiang (Duke) - "Chromatin Remodeling in Patient-Derived Colorectal Cancer Models" |
| 3:50 – 4:00 p.m. | Break 2 |
| Session 6 Chair- K-T Varley (Utah) |
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| 4:00 – 4:20 p.m. | PIs from Day 2 Presentations lead discussion on “Challenges and next steps” |
| 4:20 – 4:30 p.m. | Konstantin Salnikow - Closing Remarks |