dcb-pdmc (Agenda)

The National Cancer Institute
Division of Cancer Biology
Patient Derived Models of Cancer Consortium
Annual Meeting 2020
November 4–5, 2020
Virtual Event

Agenda

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November 4-5, 2020 (All time listed as EDT)

Wednesday, November 4, 12:00 p.m. – 5:00 p.m. ET

12:00 – 12:10 p.m.

Welcome
Konstantin Salnikow
Program Director, Division of Cancer Biology, NCI

Dan Gallahan
Director of Division of Cancer Biology, NCI
12:10 -12:20 p.m.

Introduction of CSBC
Shannon Hughes
Program Director, Division of Cancer Biology, NCI
12:20 – 1:00 p.m.

Keynote Speaker
Spatially Resolved Profiling of Early Melanoma to Study Tumor Progression and Immune Editing
Peter Sorger,Harvard Medical School

(30 min), questions (10 min)
1:00 – 1:40 p.m.

Session 1: Clinical translation
Session Moderator: Rosalie C. Sears,
Oregon Health & Science University
1:00 -1:20 p.m.

Epigenetic Reprogramming of Colon Cancer Models
Xiling Shen, Duke University
1:20 -1:40 p.m.

Co-Clinical Patient-derived Models and Personalized Medicine for Breast cancer
Bryan Welm, University of Utah
1:40 – 2:00 p.m.

Group Discussion – Session 1
Led by:
Sandra Scherer
Shree Bose
2:00 – 2:30 p.m.

Break
2:30 - 3:30 p.m.

Mini Talks-Poster Session (1 hour)
Session Moderator:
Jonathan Brody, Oregon Health & Science University
3 min, lightning poster highlights, pre-recorded, 3 min live questions
3:30 – 4:10 p.m.

Session 2: Intra-tumor heterogeneity
Session Moderator:
Sajina Gc, University of Alabama at Birmingham
3:30 – 3:50 p.m.

In situ Human Pancreatic Cancer Xenograft Models
David Tuveson, Cold Spring Harbor Laboratory
3:50 – 4:10 p.m.

Steady-state Metabolic Profiling of Renal Cell Carcinoma Patient-derived Xenografts and Derived Tissue Slice Cultures
Renuka Sriram, University of California San Francisco
4:10 - 4:30 p.m.

Group Discussion – Session 2
Led by:
Giuseppina Caligiuri
Shubhangi Agarwal
4:30 – 5:00 p.m.

Virtual social event

Thursday, November 5, 12:00 p.m. – 4:00 p.m. ET

12:00 -12:40 p.m.

Session 3: Emerging technology
Session Moderator:
Xiling Shen, Duke University
12:00 – 12:20 p.m.

Identifying Glioblastoma Multiform (GBM) Subytpes Across Heterogeneous Transcriptome Profiling Data Sets with Robust and Interpretable Gene Signatures
Jake Y. Chen, University of Alabama at Birmingham
12:20 – 12:40 p.m.

KCNA1 is Regulated by a Novel Set of miRNAs to Drive Pediatric Glioblastoma Invasion
Xiao-Nan Li, Ann & Robert H. Lurie Children’s Hospital of Chicago
12:40 – 1:00 p.m.

Group Discussion – Session 3
Led by:
Yuchen Du
Amber Jones
1:00 – 1:40 p.m.

Session 4: Tumor Systems Biology
Session Moderator:
Donna Peehl, University of California San Francisco
1:00 – 1:20 p.m.

Leveraging Patient-Derived Models to Study Mechanisms of Tolerance to Tyrosine Kinase Inhibitors in EGFR Mutant Lung Cancer
Katerina Politi, Yale University School of Medicine
1:20 – 1:40 p.m.

The MDA PCa PDX series, a Dynamic Resource that Captures the Molecular Landscape of PCa and is a Platform for Discovery
Nora M. Navone, University of Texas MD Anderson Cancer Center
1:40 – 2:00 p.m.

Group Discussion – Session 4
Led by:
Estefania Labanca
Bomiao Hu
2:00 – 2:10 p.m.

Break (10 min)
2:10 – 3:10 p.m.

Mini Talks-Poster session (1 hour)
Session Moderator:
Paul Robson, Jackson Lab
3 min, lightning poster highlights, pre-recorded, 3 min live questions
3:10 – 3:20 p.m.

Break (10 min) – time to discuss and score posters for the awards
3:20 – 4:00 p.m.

Session 5: The tumor microenvironment
Session Moderator:
Bryan Welm, University of Utah
3:20 – 3:40 p.m.

Patient-derived Modeling of Pancreatic Cancer Tumor and Stromal Heterogeneity
Rosalie Sears, Oregon Health & Science University
3:40 – 4:00 p.m.

Lymph Protects Metastasizing Melanoma Cells from Ferroptosis
Sean J. Morrison, University of Texas Southwestern Medical Center
4:00 – 4:20 p.m.

Group Discussion – Session 5
Led by:
Jessalyn Ubellacker
Samantha Brown
4:20 – 4:30 p.m.

Concluding remarks and poster awards
Konstantin Salnikow, Katerina Politi