The Immuno-Oncology Translational Network (IOTN) Capstone meeting will highlight scientific accomplishments across the IOTN. This will be a hybrid meeting held May 14-15, 2024 with both virtual and in person (Masur Auditorium, Building 10, NIH Bethesda main campus). The scientific objectives of the IOTN are to foster collaborative team science approaches to accelerate the discovery of new immune targets and evaluate novel immune-based therapies and combination approaches that eliminate established cancers in adults or to prevent cancers before they occur. The IOTN Capstone meeting will feature a) keynote talks, b) presentations by IOTN early career scientists, and c) an overview presentation on data sharing resources by the IOTN Data Management and Resource-Sharing Center. This will be a hybrid meeting with both in-person and virtual options.