ccr-covid19symposium (Agenda)

NIH COVID-19 Research Workshop


October 29–30, 2020
Virtual Event

Agenda

DAY ONE Thursday, October 29, 2020

OPENING
11:00 AM Anthony Fauci COVID-19: Public Health and Scientific Challenges
11:25 AM SESSION I: Tracking, diagnostics and prevention
Chairs: Kaitlyn Sadtler and Pamela Schwartzberg
11:25 AM Kaitlyn Sadtler Mapping a pandemic: SARS-CoV-2 seropositivity in the united states
11:40 AM Kaiyuan Sun Transmission heterogeneities, kinetics, and controllability of SARSCoV- 2
11:50 AM Barney Graham mRNA-1273 vaccine rapidly controls SARS-CoV-2 infection in upper and lower airways of non-human primates
12:05 PM Neeltje van Doremalen ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques
12:15 PM Michael Abers An immune-based biomarker signature is associated with mortality in COVID-19 patients
12:30 PM Yu Zhang Genetic contributions of type I IFN immunity in patients with lifethreatening COVID-19 infections
12:35 PM BREAK  
1:00 PM SESSION II: Virology I: Replication, Evolution, and Host Factors
Chairs: Vinay Pathak and Nihal Altan-Bonnet
1:00 PM Nihal Altan-Bonnet Coronaviruses use lysosomal organelles for cellular egress.
1:15 PM Scarlett Shi Opposing activities of IFITM proteins in SARS-CoV-2 infection
1:30 PM Cheng man Lun Antagonism of viral envelope glycoproteins by cellular membraneassociated- RING-CH (MARCH) proteins
1:45 PM Alexander Foo The mosquito protein AEG12 exerts broad-spectrum antiviral activity through lipid membrane disruption
1:55 PM Asis Khan Role of recombination in the emergence and in situ evolution of SARS-CoV-2
2:10 PM Blake Warner An integrated single-cell oral atlas for SARS-CoV-2 infection and transmission
2:15 PM Yihong Ye Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs
2:20 PM Emily Lee Development and characterization of 3D cellular lung model platforms for studying high impact respiratory viruses and rapid testing of anti-viral agents
2:40 PM BREAK  
3:00 PM SESSION III: Virology II: Structure, Function, and Inhibition of Viral Proteins
Chairs: Robin Stanley and Mario Borgnia
3:00 PM Dominic Esposito Optimization of protein reagent production for serology assays of SARS-CoV-2
3:05 PM Tongqing Zhou A pH-dependent switch that mediates endosomal positioning of SARS-CoV-2 spike receptor-binding domains
3:15 PM Adam Olia Stability and folding hysteresis of the SARS-CoV-2 spike glycoprotein
3:20 PM Mitchell Ho Isolation of nanobodies against SARS-CoV-2
3:25 PM Javeed Dhobi Binding and structural studies of single domain antibodies to SARSCoV- 2 spike protein
3:30 PM Venkata Dandey Structural characterization of SARS-CoV-2 spike in complex with neutralizing humanized nanobodies
3:40 PM Jinghua Lu High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity
3:45 PM Nadya Tarasova Discovery of SARS-CoV-2 protein ligands by virtual screening of novel ultra-large libraries of synthetically accessible compounds
3:55 PM Meredith Frazier Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics
4:05 PM Nunziata Maio The RNA dependent RNA polymerase of SARS-CoV2 requires two iron-sulfur clusters for function that are sensitive to oxygen and chemical oxidants
4:15 PM David Davis Activity and dimerization of the main protease of SARS2 coronavirus is regulated through reversible oxidation
4:25 PM Kirill Gorshkov Quantum dot-conjugated SARS-CoV-2 spike pseudo-virions enable tracking of angiotensin converting enzyme 2 binding and endocytosis
4:40 PM BREAK  
5:00 PM FLASHTALKS I.a Public Health and Health Disparities
Chairs: Tiffany Powell-Wiley, Brigitte Sanders, Daniella Schwartz
  Eliza Gordon-Lipkin Understanding the experience of the mitochondrial disease community during the COVID-19 pandemic
  Amanda Perofsky Utilizing respiratory syndromic surveillance data to monitor COVID-19 activity in South Africa
  Miya Whitaker ORWH guidance on the importance of reporting sex and gender and the inclusion of women and minorities in COVID-19 research
  Udana Torian Evaluating the disproportionate COVID-19 impact on minority communities in the US
  Alison Motsinger- Reif The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning
  Monica Webb Hooper NIH community engagement alliance (CEAL) against COVID-19 disparities: engaging trusted voices to address the pandemic
  Vijay Ramchandani Impact of the COVID-19 pandemic on alcohol use and related outcomes
  Jill Settle Understanding the intersection of the COVID-19 pandemic and the opioid crisis through social media: preliminary results
  Sherine El-Toukhy Use of smoking cessation digital platforms during the COVID-19 pandemic: insights from SmokFree, January to April 2019 and 2020
  Carolina Mendoza- Puccini The National Institutes of Health COVID-19 Neurodatabank & Neurobiobank: a national resource for learning, discovery, and progress
  Julia Dunn Predictors of mood/anxiety symptoms during the COVID-19 pandemic
5:00 PM FLASHTALKS I.b Diagnostics
Chairs: Dominic Esposito, Parinaz Fathi, Kaitlyn Sadtler
  Valeria De Giorgi Evaluation of Roche cobas® SARS-CoV-2 assay in pooled midturbinate specimens
  Oliver Laeyendecker Comparative performance of 15 lateral flow assays and five commercially available serologic assays to detect antibodies to SARS-CoV-2 and identify individuals with high neutralizing titers
  Kamille West Anti-SARS-CoV-2 seropositivity in healthy blood donors at NIH
  Flegel Bill Assay development for antibodies to COVID-19 virus in human plasma
  Uriel Ortega-Rodriguez Development of serologic tests to detect SARS-CoV-2 specific antibodies in preclinical and clinical samples
  Jacquelyn Spathies Standardization of semiautomatic enzyme-linked immunosorbent assays for serosurvey of SARS-CoV-2 coronavirus
  George Pavlakis Analysis of humoral and cellular immune responses in SARS-CoV-2 convalescent patients to inform vaccine development
  Dipak Poria Development of an RNAseH-assisted detection assay for RNA (radar): application in SARS-CoV-2 nucleic acid diagnostics
  Camila Silva Surveillance of SARS-CoV-2 in wastewater as a complementary tool to estimate the viral spread in Arkansas
  Tauseef Rehman New assays for detection of antibody response to SARS-CoV-2
  Kenneth Adusei Investigating SARS-CoV-2 prevalence in trauma patients
5:00 PM FLASHTALKS I.c Therapeutics
Chairs: Mohanraj Manangeeswaran, Bob Yarchoan, Mitchell Ho
  Hoda Zarkoob Utilizing three-dimensional human lung tissue models for anti-viral respiratory drug screening
  Jonathan Shrimp An enzymatic TMPRSS2 assay for assessment of clinical candidates and discovery of inhibitors as potential treatment of COVID-19
  Jason Watts Treatment of COVID-19 by silencing SARS-CoV2 genes with antisense technology
  Kenneth Jacobson Potential role for purinergic receptor modulators in managing COVID-19
  Wei Zhu Identification of SARS-CoV-2 3CL protease inhibitors by a quantitative high-throughput screening
  Christopher Lien A rocaglate pyrimidinone inhibits SARS-CoV-2 infection
  Seung Bum Park Targeting entry of SARS-CoV-2 infection by small molecule inhibitors
  Richard Eastman Elucidation of potential repurposing drug combinations for SARSCoV- 2
  Sinu John Small molecule long-term modulators of innate immune signaling inhibits coronavirus infection in macrophage cells
  Sameer Kadri Real-world inpatient use of medications repurposed for COVID-19 in US Hospitals
  Andrew Mannes Reliable, inexpensive, emergency respirator for use with the COVID-19 pandemic
5:00 PM FLASHTALKS I.d Pathogenesis I/Immunology
Chairs: Xuguang Tai, Nicole Doria Rose, Howard Young
  Hyung Joon Kwon Systems serology of SARS-CoV-2 specific antibodies in COVID-19 inpatients
  Ottavia Delmonte Defective adaptive immune responses in patients with COVID-19 and hematological malignancies
  Kalpana Manthiram Characterization of mucosal oropharyngeal immune responses to SARS-CoV2 in children
  Mohammad Arif Rahman Role of monocytes in SARS-CoV-2 infection of macaques
  Hye Kyung Lee Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
  Gayatri Sanku Unraveling the immune repertoire of SARS-CoV2-specific human T cell lines generated from unexposed individuals
  Jessica Durkee-Shock Phenotype and functionality of SARS-CoV-2 specific t-cells derived from convalescent donors via rapid expansion protocol
  Victoria Avanzato Prolonged infectious SARS-CoV-2 shedding from an immunocompromised patient
  Wesley Tung Determining the genetic contributions of the viral RNA sensor RIGI for severe COVID-19 infection susceptibility
  Briana Turner Interferon gamma may be a critical target for chronic stressassociated SARS-CoV-2 disparities

 

DAY TWO Friday, October 30, 2020

10:00 AM FLASHTALKS II.a Data Science
Chairs: Sean Davis, Sherine El-Toukhy, Carson Chow
  Jungmin Han Bayes model comparison of epidemic on network predictions for SARS-CoV-2 paramete
  Sean Davis sars2pack: an open approach providing fit-for-use COVID-19 data resources
  Tara Eicher Pathway analysis using gene and metabolite co-involvement graphs highlights shared pathways in independent serum metabolomics cohorts from the NCATS COVID-19 OpenData portal
  Osman Yogurtcu Evaluation of epidemiological models to estimate and predict COVID-19 impact
  Dina Demner-Fushman Information retrieval, question answering and misinformation detection for COVID-19 researchers, responders, and the public
  Matthew Hall The COVID-19 response at NCATS: drug repurposing and the OpenData portal
  Parvesh Paul Capturing clinician’s experiences repurposing drugs to inform future studies during COVID-19
  Philippe Youkharibache Using iCn3D and the world wide web for structure-based collaborative research: analyzing molecular interactions at the root of COVID-19
  Evan Cresswell-Clay Phylogenetic prediction of SARS-CoV-2 protein contact networks
10:00 AM FLASHTALKS II.b Virology/Basic Science
Chairs: Diana Finzi, Jake Liang, Mario Borgnia
  Claude Yinda Kwe The effect of temperature and humidity on the stability of SARSCoV- 2 and other coronaviruses
  Olive Jung Development of human three-dimensional lung parenchyma cellular model with perfused vasculature in an organ-on-a-chip platform to elucidate the pathology of respiratory virus infections and diseases and for drug screening
  Paige Derr Viral infection of engineered 3D gut tissues
  Shufeng Liu The PRRA insert at the S1/S2 site modulates cellular tropism of SARS-CoV-2 and ACE2 usage by the closely related bat raTG13
  Raul Cachau Analysis of SARS-CoV-2 ORF3a structure reveals chloride binding sites
  Amirhossein Manzourolajdad Predicted spike-ORF8 RNA-RNA interaction unique to SARS-CoV-2 may impact n-gene sub-genomic RNA synthesis
  Michael Chambers High-throughput screening of CoV-2 spike protein and ACE2 receptor
  Kirill Gorshkov Development of a high-throughput homogeneous AlphaLISA drug screening assay for the detection of SARS-CoV-2 nucleocapsid
  Alex Renn Discovery and engineering of humanized neutralizing nanobodies against SARS-CoV-2
10:00 AM FLASHTALKS II.c Pathogenesis II
Chairs: Claudia Cicala, Ludmila Prokunina-Olsson, Andrew Redd)
  Jakub Jankowski Cytokine regulation of a novel short form of the SARS-CoV-2 receptor ACE2 in kidney
  Natalie Shaw Epigenetic control of ACE2 by the chromatin remodeler, smchd1
  Joseph Rodriguez Dynamic hormone regulation of ACE2 and TMPRSS2 co-expression in single cells
  Kevin Vannella An apparent paradox in postmortem heart tissue of COVID-19 patients
  Federica La Russa Exploring the pathophysiology and potential treatments of lethal respiratory viral infections using a systems biology approach in vivo
  Wen Han Local zoom CT for detailed assessment of lung pathology in COVID- 19 patients
  Amanda Henning Concordance of antibody levels and neutralizing activity in COVID- 19 convalescent plasma donors
  Naoko Tsuji SARS-CoV-2 remote tissue injury: - cell-free DNA from COVID-19 patient plasma generates mitochondrial superoxide in kidney tubule cells.
  Marcos J. Ramos-Benitez Evaluating netosis induction potential in severe and fatal cases of COVID-19
  Komudi Singh Delineating the common biological signatures in COVID -19 and chronic fatigue syndrome (CFS) patients
10:00 AM FLASHTALKS II.d Vaccines
Chairs: Danny Douek, Maja Buszko, Ranjan Sen
  Puthupparampil Scaria Receptor binding domain (RBD) conjugate vaccine against SARSCoV- 2
  Barbara Felber Cov-2 DNA vaccine development
  Yongping Yang Design of SARS-CoV2 spike pre-fusion membrane anchored Newcastle disease virus-like particle vaccine
  Viviana Pszenny VLP-based oral vaccine against COVID-19
  Ruikang Liu Prime-boost immunizations with SARS cov-2 spike protein expressed by an MVA vector stimulate strong neutralizing antibodies and CD8+ T cells
  Ira Berkower Live rubella/S1 vaccine for protection against SARS-CoV-2
  Anthony DiPiazza SARS-CoV-2 spike mRNA vaccination elicits a distinct immunological signature in mice associated with protection that does not cause vaccine-associated enhanced respiratory disease
  Nicole Doria-Rose Immunogenicity of SARS-CoV-2 vaccine mRNA1273 in older and younger adults
  Shanna Leventhal A novel DNA vaccine for SARS-2 tested in Syrian hamsters
11:10 AM BREAK  
11:30 AM KEYNOTE
Francis Collins
 
NIH Director’s Perspectives on COVID-19 Research
11:50 AM SESSION IV: Clinical Manifestations and Pathogenesis
Chairs: Irini Sereti and Sean Agbor-Enah
11:50 AM Temesgen Andargie Cell-free DNA quantification and methylation profiling to monitor tissue damage in COVID-19 patients
12:05 PM Yogen Kanthi Thrombo-inflammatory regulation of COVID-19
12:20 PM Paule Joseph COVID-19: a spotlight on the chemical senses, how the knows nose?
12:30 PM Eduardo Amaral Evaluating the role of oxidative stress in COVID-19 disease
12:40 PM Benjamin Schwarz Eicosanoid immune lipid mediator dysregulation mechanistically links metabolic comorbidities to severe SARS-CoV-2 infection in humans
12:45 PM Ben Afzali An autocrine vitamin D-driven Th1 shutdown program can be exploited for COVID-19
12:50 PM Florian Thibord The grasp COVID-19 portal for the study of COVID-19 host genomics
12:55 PM Sheri Schully All of Us research program COVID-19 research initiatives
1:00 PM Sandeep Narpala SARS-CoV-2 antibody levels persist from five weeks to three months in COVID-19 PCR confirmed cohort
1:05 PM Bradford Wood CT artificial intelligence tools for detection, classification, quantification, and drug discovery in COVID-19
1:10 PM Sydney Stein In utero SARS-CoV-2 infection
1:10 PM BREAK  
1:30 PM SESSION V: Host Response and Immunology
Chairs: Mihalis Lionakis and Naomi Taylor
1:30 PM Can Liu Longitudinal multimodal single cell analyses of COVID-19 reveal disease severity network and critical immune response juncture
1:45 PM Peer Karmaus Airway immune responses in COVID-19: a meta-analysis using single cell transcriptomics
1:55 PM Yvonne Baumer Neighborhood deprivation associates with decreased monocyte TLR2 expression via TNFa potentially contributing to SARS-CoV-2 disparities in African Americans
2:10 PM Phillip Swanson Evaluation of T cell responses in human subjects vaccinated with mRNA-1273
2:20 PM Andrew Redd Broad and prevalent SARS-CoV-2 CD8+ T cell response in recovered COVID-19 individuals
2:30 PM Ludmila Prokunina-Olsson Interferons and viruses induce a novel truncated isoform dACE2 and not the SARS-CoV-2 receptor ACE2
2:40 PM Silvia Lucena Lage Nlrp3 inflammasome activation in cd14highcd16- monocytes from COVID-19 patients
2:50 PM Ben Afzali SARS-CoV-2 drives JAK1/2-dependent local and systemic complement hyper-activation
3:00 PM Dorothy Butler Serum profiling reveals unusual antibodies to self-carbohydrates in SARS-CoV-2 infected patients
3:05 PM Limin Wang Serological responses to human virome define clinical outcomes of Italian patients infected with SARS-CoV-2
3:10 PM BREAK  
3:30 PM SESSION VI: Animal Models and Vaccines
Chairs: Pamela Schwartzberg and Sonja Best
3:30 PM Emily Speranza Single-cell sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys
3:45 PM Lydia Roberts Expansion of pulmonary-resident CD4+ and CD8+ T cells following SARS-CoV-2 infection
4:00 PM Shelly Robertson Development of a mouse model for severe coronavirus disease 19 (COVID-19)
4:15 PM Julia Port Natural routes of infection determine transmission dynamics and disease manifestation of SARS-CoV-2 in the Syrian golden hamster
4:25 PM Prabhuanand Selvaraj SARS-CoV-2 infection induces near sterilizing immunity in the lung and limits transmission in Syrian hamsters
4:35 PM Ji Hyun Lee Characterization of SARS-CoV-2-induced disease in golden hamsters by CT and 18F-FDG-PET
4:40 PM Forrest Jessop SARS-CoV-2 evades triggering host metabolic reprograming early following infection
4:45 PM Meseda Clement Characterization of protective immune responses to different forms of MVA-expressed SARS-CoV-2 s protein using mouse and hamster models
4:50 PM Zhang Baoshan SARS-CoV-2-spike nanoparticles elicit substantially higher neutralizing responses than spike alone
5:10 PM Closing remarks
Michael Gottesman
 

 

Acknowledgements

We would like to thank Dr. Anthony Fauci, Dr. Francis Collins and Dr. Michael Gottesman for their invaluable leadership, contributions and participation in the workshop.

We would also like to thank our wonderful session chairs: Tiffany Powell-Wiley, Brigitte Sanders, Daniella Schwartz, Kaitlyn Sadtler, Matt Hall, Parinez Fathi, Mohanraj Manangeeswaran, Bob Yarchoan, Mitchell Ho, Howard Young, Xuguang Tai, Nicole Doria Rose, Carson Chow, Sean Davis, Sherine El-Toukay, Diana Finzi, Jake Liang, Claudia Cicala, Ludmila Prokunina-Olsson, Andrew Redd, Danny Douek, Maja Busczo, Ranjan Sen, Pamela Schwartzberg, Vinay Pathak, Nihal Altan- Bonnet, Mario Borgnia, Robin Stanley, Irini Sereti, Sean Agbor-Enah, Mihalis LIonakis, Naomi Taylor and Sonja Best, as well as Parinaz Fathi and Joe Rocco, for their help in organizing the workshop sessions.

We would also like to give a big thanks to the NCI, especially Howard Young, Janene Nusraty, and Jose Aragon, Maurice Edmonds, Michael Rinaldi and their staff from the NCI Center for Biomedical Informatics and Information Technology.

We would also like to thank the Office of Intramural Research especially Michael Gottesman, Chris Wanjek, Chuck Dearolf, Jackie Roberts and Karen Nemes for suggesting the idea of having this workshop in lieu of the NIH Research Festival and for their support in making it happen.

And most of all we would like to all the study participants who have volunteered in drug and vaccine trials and our workshop speakers and other researchers from the NIH and the FDA for all their hard work on COVID-19.

With many thanks from the COVID-19 Scientific Interest Group Steering committee:

Mario Borgnia
Carson Chow
Mihalis Lionakis
Vinay Pathak
Kaitlyn Sadtler
Pamela Schwartzberg
Irini Sereti